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1.发明申请Vaccine comprising gp120 and nef and/or tat for the immunisation against hiv 审中-公开包含gp120和nef和/或tat的疫苗用于免疫接种公开(公告)号：US20050058657A1
公开(公告)日：2005-03-17
申请号：US10485048
申请日：2002-07-26
申请人： Peter Ertl , John Tite , Catherine Van Wely , Gerald Voss
发明人： Peter Ertl , John Tite , Catherine Van Wely , Gerald Voss
IPC分类号： C12N15/09 , A61K9/00 , A61K31/7088 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/21 , A61K47/02 , A61K48/00 , A61P31/18 , A61P37/04 , C07K14/16 , C12N15/49 , C12N15/89 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C07K2319/00 , C12N15/895 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide: and an HIV gp 120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV, wherein the protein or polynucleotide is delivered via a bombardment approach.
摘要翻译： 使用a）HIV Tat蛋白或多核苷酸; 或b）HIV Nef蛋白或多核苷酸; 或c）与HIV Nef蛋白质或多核苷酸连接的HIV Tat蛋白质或多核苷酸：和HIV gp120蛋白质或多核苷酸，其制造适合用于预防或治疗性免疫HIV的初次加强递送疫苗， 其中所述蛋白质或多核苷酸通过轰击方法递送。
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2.发明申请VACCINE COMPRISING GP120 AND NEF AND/OR TAT FOR THE IMMUNIZATION AGAINST HIV 审中-公开包含GP120的疫苗和用于免疫艾滋病毒免疫的NEF和/或TAT公开(公告)号：US20080102085A1
公开(公告)日：2008-05-01
申请号：US11874552
申请日：2007-10-18
申请人： Peter Ertl , John Tite , Catherine Van Wely , Gerald Voss
发明人： Peter Ertl , John Tite , Catherine Van Wely , Gerald Voss
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C07K2319/00 , C12N15/895 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide; and an HIV gp120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV, wherein the protein or polynucleotide is delivered via a bombardment approach.
摘要翻译： 使用a）HIV Tat蛋白或多核苷酸; 或b）HIV Nef蛋白或多核苷酸; 或c）与HIV Nef蛋白或多核苷酸连接的HIV Tat蛋白或多核苷酸; 和HIV gp120蛋白或多核苷酸，其制造适合用于预防或治疗性免疫HIV抗原的初次加强递送的疫苗，其中所述蛋白质或多核苷酸通过轰击方法递送。
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公开(公告)号：US20050266024A1
公开(公告)日：2005-12-01
申请号：US10507928
申请日：2003-03-19
申请人： Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
发明人： Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
IPC分类号： C12N15/09 , A61K9/06 , A61K9/18 , A61K31/4745 , A61K39/00 , A61K39/21 , A61K39/39 , A61K45/06 , A61K48/00 , A61P31/18 , A61P37/04 , C07D471/04 , C07K14/16
CPC分类号： C07K14/005 , A61K31/4745 , A61K39/12 , A61K39/21 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55511 , A61K2039/55555 , C12N2730/10134 , C12N2740/16222 , C12N2740/16234 , A61K2300/00
摘要： The relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要翻译： 涉及某些佐剂组合物，以及使用这种组合物的疫苗和/或核酸免疫策略。 本发明特别涉及可用于预防和治疗HIV感染的DNA疫苗，特别是当通过颗粒介导的递送施用时。
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公开(公告)号：US20050256070A1
公开(公告)日：2005-11-17
申请号：US11029465
申请日：2005-01-06
申请人： Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
发明人： Ralph Braun , Lindy Thomsen , Catherine Van-Wely , Peter Ertl
CPC分类号： C07K14/005 , A61K31/4745 , A61K39/12 , A61K39/21 , A61K39/39 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , C12N2710/16634 , C12N2740/16222 , C12N2740/16234 , A61K2300/00
摘要： The present invention relates to the fields of vaccines, vaccine adjuvants, molecular biology and immunology, and generally adjuvants and nucleic acid immunization techniques. More specifically, the invention relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions. The invention in particular relates to DNA vaccines that are useful in the prophylaxis and treatment of HIV infections, more particularly when administered by particle mediated delivery.
摘要翻译： 本发明涉及疫苗，疫苗佐剂，分子生物学和免疫学领域，通常是佐剂和核酸免疫技术。 更具体地，本发明涉及某些佐剂组合物，以及使用这种组合物的疫苗和/或核酸免疫策略。 本发明特别涉及可用于预防和治疗HIV感染的DNA疫苗，特别是当通过颗粒介导的递送施用时。
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公开(公告)号：US20070015721A1
公开(公告)日：2007-01-18
申请号：US10490011
申请日：2002-09-18
申请人： Andrew Beaton , Peter Ertl , Gerald Gough , Andrew Lear , John Tite , Catherine Van Wely
发明人： Andrew Beaton , Peter Ertl , Gerald Gough , Andrew Lear , John Tite , Catherine Van Wely
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C07K14/005 , C07K2319/00 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment thereof and RT or a fragment thereof.
摘要翻译： 本发明提供编码HIV-1gag蛋白或其片段的核苷酸序列，其含有gag表位和第二HIV抗原或编码所述第二HIV抗原表位的片段，其可操作地连接到异源启动子。 优选的多核苷酸序列进一步编码nef或其片段和RT或其片段。
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