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    Inhibitors of Bruton's tyrosine kinase
    1.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 有权
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08426409B2

    公开(公告)日：2013-04-23

    申请号：US12460387

    申请日：2009-07-17

    申请人： Rama K. Kondru ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    发明人： Rama K. Kondru ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D401/00 ,  C07D403/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00

    CPC分类号： C07D487/04

    摘要： This application discloses 6-Phenyl-imidazo[1,2-a]pyrazine derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式IV的6-苯基 - 咪唑并[1,2-a]吡嗪衍生物：其中变量Q，R，Y 1，Y 2，Y 3，Y 4，n和m如本文所述定义，其抑制 Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了包含式I-V化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of bruton's tyrosine kinase
    2.
    发明申请
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US20100016302A1

    公开(公告)日：2010-01-21

    申请号：US12460387

    申请日：2009-07-17

    申请人： Rama K. Kondru ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    发明人： Rama K. Kondru ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    IPC分类号： A61K31/5377 ,  A61K31/502 ,  A61K31/4985 ,  C07D487/04 ,  A61P37/02

    CPC分类号： C07D487/04

    摘要： This application discloses 6-Phenyl-imidazo[1,2-a]pyrazine derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式IV的6-苯基 - 咪唑并[1,2-a]吡嗪衍生物：其中变量Q，R，Y 1，Y 2，Y 3，Y 4，n和m如本文所述定义，其抑制 Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了包含式I-V化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of bruton's tyrosine kinase
    3.
    发明授权
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US08324211B2

    公开(公告)日：2012-12-04

    申请号：US12460226

    申请日：2009-07-15

    申请人： Nolan James Dewdney ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    发明人： Nolan James Dewdney ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    IPC分类号： A61K31/50 ,  C07D237/00

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： This application discloses 6-Phenyl-imidazo[1,2-a]pyridine and 6-Phenyl-imidazo[1,2-b]pyridazine derivatives according to generic Formulae I-V: wherein, variables Q, R, X, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式IV的6-苯基 - 咪唑并[1,2-a]吡啶和6-苯基 - 咪唑并[1,2-b]哒嗪衍生物：其中，变量Q，R，X，Y 1， Y3，Y4，n和m如本文所述限定Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了包含式I-V化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of bruton's tyrosine kinase
    5.
    发明申请
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US20100016301A1

    公开(公告)日：2010-01-21

    申请号：US12460226

    申请日：2009-07-15

    申请人： Nolan James Dewdney ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    发明人： Nolan James Dewdney ,  Yan Lou ,  Eric Brian Sjogren ,  Michael Soth

    IPC分类号： A61K31/5377 ,  C07D487/04 ,  A61K31/437 ,  C07D471/04

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： This application discloses 6-Phenyl-imidazo[1,2-a]pyridine and 6-Phenyl-imidazo[1,2-b]pyridazine derivatives according to generic Formulae I-V: wherein, variables Q, R, X, Y1, Y2, Y3, Y4, n, and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式IV的6-苯基 - 咪唑并[1,2-a]吡啶和6-苯基 - 咪唑并[1,2-b]哒嗪衍生物：其中，变量Q，R，X，Y 1， Y3，Y4，n和m如本文所述限定Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了包含式I-V化合物和至少一种载体，稀释剂或赋形剂的组合物。