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1.发明申请TOPICAL FORMULATION(S) FOR THE TREATMENT OF INFLAMMATION, SKIN AND MUCOSAL DISORDERS AND OTHER DISEASES THEREOF 失效用于治疗炎症，皮肤和粘膜疾病及其他疾病的主题配方公开(公告)号：US20120052095A1
公开(公告)日：2012-03-01
申请号：US13132155
申请日：2011-06-01
申请人： Ramchand Nanappan Chaniyilparampu , Madhavi Mungala , Anuj Kapoor , Ganga Raju Gokaraju , Rama Raju Gokaraju , Bhupathiraju Kiran , Trimurtulu Golakoti , Anitha Krishnan Nair , Malliga Raman Murali , Kavitha Parthasarathy
发明人： Ramchand Nanappan Chaniyilparampu , Madhavi Mungala , Anuj Kapoor , Ganga Raju Gokaraju , Rama Raju Gokaraju , Bhupathiraju Kiran , Trimurtulu Golakoti , Anitha Krishnan Nair , Malliga Raman Murali , Kavitha Parthasarathy
IPC分类号： A61K9/107 , A61K31/12 , A61P17/02 , A61P17/00 , A61P17/10 , A61P17/06 , A61P31/04 , A61P31/12 , A61P37/08 , A61P7/00 , A61K31/4406 , A61P29/00
CPC分类号： A61K31/12 , A61K9/0014 , A61K9/1075 , A61K31/455 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/42 , A61K47/44 , A61K2300/00
摘要： Nanoemulsified topical formulation comprising curcumin, tetrahydroxycurcumin (BDMC) and curcuminoid either alone or in combinations in an amount of 0.001% to 50% together with one or more pharmaceutically, nutraceutically or dietically acceptable excipient(s) or inactive ingredients, useful for the treatment of inflammation, various skin and oral disorders, mucosal disorders and other diseases associated or related thereof.
摘要翻译： 包含姜黄素，四羟基姜黄素（BDMC）和姜黄素的纳米乳剂化局部制剂，其单独或组合0.001％至50％，以及一种或多种药学上，营养学上或饮食上可接受的赋形剂或非活性成分，其可用于治疗 炎症，各种皮肤和口腔疾病，粘膜疾病和与其有关的其它疾病。
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2.发明授权Topical formulation(s) for the treatment of inflammation, skin and mucosal disorders and other diseases thereof 失效用于治疗炎症，皮肤和粘膜疾病及其他疾病的外用制剂公开(公告)号：US08535693B2
公开(公告)日：2013-09-17
申请号：US13132155
申请日：2011-06-01
申请人： Ramchand Nanappan Chaniyilparampu , Madhavi Mungala , Anuj Kapoor , Ganga Raju Gokaraju , Rama Raju Gokaraju , Kiran Bhupathiraju , Trimurtulu Golakoti , Anitha Krishnan Nair , Malliga Raman Murali , Kavitha Parthasarathy
发明人： Ramchand Nanappan Chaniyilparampu , Madhavi Mungala , Anuj Kapoor , Ganga Raju Gokaraju , Rama Raju Gokaraju , Kiran Bhupathiraju , Trimurtulu Golakoti , Anitha Krishnan Nair , Malliga Raman Murali , Kavitha Parthasarathy
IPC分类号： A61K9/00
CPC分类号： A61K31/12 , A61K9/0014 , A61K9/1075 , A61K31/455 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/42 , A61K47/44 , A61K2300/00
摘要： Nanoemulsified topical formulation comprising curcumin, tetrahydroxycurcumin (BDMC) and curcuminoid either alone or in combinations in an amount of 0.001% to 50% together with one or more pharmaceutically, nutraceutically or dietically acceptable excipient(s) or inactive ingredients, useful for the treatment of inflammation, various skin and oral disorders, mucosal disorders and other diseases associated or related thereof.
摘要翻译： 包含姜黄素，四羟基姜黄素（BDMC）和姜黄素的纳米乳剂化局部制剂，其单独或组合0.001％至50％，以及一种或多种药学上，营养学上或饮食上可接受的赋形剂或非活性成分，其可用于治疗 炎症，各种皮肤和口腔疾病，粘膜疾病和与其有关的其它疾病。
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3.发明申请CURCUMINOIDS AND ITS METABOLITES FOR THE APPLICATION IN OCULAR DISEASES 审中-公开CURCUMINOIDS及其代谢物在眼科疾病中的应用公开(公告)号：US20110212142A1
公开(公告)日：2011-09-01
申请号：US13127590
申请日：2009-11-17
申请人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kavitha Parthasarathy , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
发明人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kavitha Parthasarathy , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
CPC分类号： A61K36/9066 , A61K9/0048 , A61K9/1075 , A61K31/12
摘要： Aqueous ophthalmic compositions comprising natural or synthetic curcuminoids either alone or in combination, nonionic surfactant and co-solvent along with suitable ophthalmic excipients, effective in increasing the bioavailability of the active compounds when administered topically to the eye is disclosed herein.
摘要翻译： 本文公开了包含单独或组合的天然或合成姜黄素的水性眼用组合物，非离子表面活性剂和助溶剂以及合适的眼用赋形剂，其有效地增加活性化合物在局部施用于眼睛时的生物利用度。
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公开(公告)号：US08680143B2
公开(公告)日：2014-03-25
申请号：US13002588
申请日：2009-07-06
申请人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A01N37/02 , A01N37/06 , A61K31/225
CPC分类号： C07C67/08 , C07C67/293 , C07C69/587
摘要： The invention discloses a compound of formula (I) wherein, at least one of R1, R2, R3 and R4 is —C(═O)Rn and R1, R2R3 and R4 are H or CH3 and Rn is alkyl or alkenyl group. The alkenyl group have one or more number of double bonds either in cis form or trans form or both. In Rn, where n is 12 to 30 carbons; and pharmaceutically acceptable salt thereof. The said alkenyl groups are preferably selected from the group consisting of eicosapentaenoic acid (EPA) or DHA (docosahexaenoic acid). This invention further discloses processes for their preparation of compounds of formula I and pharmaceutical compositions that contain these compounds.
摘要翻译： 本发明公开了式（I）化合物，其中R 1，R 2，R 3和R 4中的至少一个为-C（= O）R n，R 1，R 2 R 3和R 4为H或CH 3，R n为烷基或链烯基。 烯基具有一个或多个数量的以顺式或反式形式或两者的双键。 在Rn中，n为12至30个碳; 及其药学上可接受的盐。 所述烯基优选选自二十碳五烯酸（EPA）或DHA（二十二碳六烯酸）。 本发明还公开了其制备式I化合物的方法和含有这些化合物的药物组合物。
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公开(公告)号：US20110112190A1
公开(公告)日：2011-05-12
申请号：US13002588
申请日：2009-07-06
申请人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
发明人： Ramchand Nanappan Chaniyilparampu , Anitha Krishnan Nair , Anuj Kapoor , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti , Venkateswarlu Somepalli
IPC分类号： A61K31/232 , C07C69/587 , C07C69/602 , C07C67/08 , A61P39/06 , A61P25/28
CPC分类号： C07C67/08 , C07C67/293 , C07C69/587
摘要： The invention discloses a compound of formula (I) wherein, at least one of R1, R2, R3 and R4 is —C(═O)Rn and R1, R2R3 and R4 are H or CH3 and Rn is alkyl or alkenyl group. The alkenyl group have one or more number of double bonds either in cis form or trans form or both. In Rn, where n is 12 to 30 carbons; and pharmaceutically acceptable salt thereof. The said alkenyl groups are preferably selected from the group consisting of eicosapentaenoic acid (EPA) or DHA (docosahexaenoic acid). This invention further discloses processes for their preparation of compounds of formula I and pharmaceutical compositions that contain these compounds.
摘要翻译： 本发明公开了式（I）化合物，其中R 1，R 2，R 3和R 4中的至少一个为-C（= O）R n，R 1，R 2 R 3和R 4为H或CH 3，R n为烷基或链烯基。 烯基具有一个或多个数量的以顺式或反式形式或两者的双键。 在Rn中，n为12至30个碳; 及其药学上可接受的盐。 所述烯基优选选自二十碳五烯酸（EPA）或DHA（二十二碳六烯酸）。 本发明还公开了其制备式I化合物的方法和含有这些化合物的药物组合物。
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6.发明申请PROCESS FOR NANOEMULSIFICATION OF CURCUMIN AND DERIVATIVES OF CURCUMIN 有权CURCUMIN和CURCUMIN衍生物的纳米化方法公开(公告)号：US20110229532A1
公开(公告)日：2011-09-22
申请号：US13129424
申请日：2009-11-17
申请人： Anitha Krishnan Nair , Ramchand Nanappan Chaniyilparampu , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
发明人： Anitha Krishnan Nair , Ramchand Nanappan Chaniyilparampu , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
CPC分类号： A61K9/14 , A23V2250/2112 , A61K9/145 , A61K9/51 , A61K9/5123 , A61K36/9066 , Y10S977/773 , Y10S977/915
摘要： A process for nanomulsification of highly lipophillic polyphenols compounds using non-ionic surfactant and a non-ionic co-solvent with the help of sonar energy, to enhance the aqueous solubility is disclosed herein.
摘要翻译： 本文公开了一种使用非离子表面活性剂和非离子型辅助溶剂借助声纳能纳米乳化高亲脂性多酚化合物以提高水溶性的方法。
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公开(公告)号：US08632815B2
公开(公告)日：2014-01-21
申请号：US13129424
申请日：2009-11-17
申请人： Anitha Krishnan Nair , Ramchand Nanappan Chaniyilparampu , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
发明人： Anitha Krishnan Nair , Ramchand Nanappan Chaniyilparampu , Kiran Bhupathiraju , Rama Raju Gokaraju , Ganga Raju Gokaraju , Trimurtulu Golakoti
CPC分类号： A61K9/14 , A23V2250/2112 , A61K9/145 , A61K9/51 , A61K9/5123 , A61K36/9066 , Y10S977/773 , Y10S977/915
摘要： A process for nanomulsification of highly lipophillic polyphenols compounds using non-ionic surfactant and a non-ionic co-solvent with the help of sonar energy, to enhance the aqueous solubility is disclosed herein.
摘要翻译： 本文公开了一种使用非离子表面活性剂和非离子型辅助溶剂借助声纳能纳米乳化高亲脂性多酚化合物以提高水溶性的方法。
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8.发明授权Agents derived from Holoptelea integrifolia and their compositions for the control of metabolic syndrome and associated diseases 有权源自全息莲的代谢物及其用于控制代谢综合征和相关疾病的组合物公开(公告)号：US09345732B2
公开(公告)日：2016-05-24
申请号：US13510815
申请日：2009-11-19
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Kiran Bhupathiraju , Venkateswara Rao Chirravuri , Sivaramakrishna Chillara
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Kiran Bhupathiraju , Venkateswara Rao Chirravuri , Sivaramakrishna Chillara
IPC分类号： A61K36/185 , A61K36/67 , A61K36/16 , A61K36/58 , A23L1/30
CPC分类号： A61K36/185 , A23L33/105 , A61K2300/00
摘要： The invention discloses phytochemical agents derived from Holoptelea integrifolia and novel composition(s) comprising at least one component selected from the extract(s), fraction(s) and active compound(s) for the protection and alleviation of Metabolic Syndrome, insulin resistance, endothelial dysfunction, chronic kidney disease, atherosclerosis, diabetes and other disease conditions associated with metabolic syndrome. The invention also discloses the amelioration of certain biomarker molecules such as Peroxisome proliferator-activated receptor gamma (PPAR-γ), Adipose Differentiation Related Protein (ADRP), CD36, Adipocyte Fatty-acid-Binding Protein (aP2/FABP-4/A-FABP), beta-3 Adrenergic Receptor (β3AR), Leptin, Perilipin and Adiponectin by using the phytochemical components derived from Holoptelea integrifolia.
摘要翻译： 本发明公开了源自全息莲的植物化学试剂和包含至少一种选自提取物，级分和活性化合物的组分的新组合物，用于保护和减轻代谢综合征，胰岛素抵抗， 内皮功能障碍，慢性肾脏疾病，动脉粥样硬化，糖尿病等与代谢综合征相关的疾病。 本发明还公开了一些生物标记分子的改进，例如过氧化物酶体增殖物激活受体γ（PPAR-γ），脂肪分化相关蛋白（ADRP），CD36，脂肪细胞脂肪酸结合蛋白（aP2 / FABP-4 / A- FABP），β-3肾上腺素能受体（＆bgr; 3AR），瘦蛋白，Perilipin和脂连蛋白，通过使用源自全息莲的植物化学成分。
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9.发明授权Composition from Sphaeranthus indicus and Garcinia mangostana for the control of metabolic syndrome 有权来自Sphaeranthus indicus和Garcinia mangostana的组成用于控制代谢综合征公开(公告)号：US09241964B2
公开(公告)日：2016-01-26
申请号：US13146965
申请日：2010-02-01
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Kiran Bhupathiraju , Krishanu Sengupta , Venkata Krishna Raju Alluri
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Venkata Kanaka Ranga Raju Gokaraju , Trimurtulu Golakoti , Kiran Bhupathiraju , Krishanu Sengupta , Venkata Krishna Raju Alluri
CPC分类号： A61K36/38 , A23L33/105 , A23V2002/00 , A61K35/12 , A61K36/28 , A61K2300/00 , A23V2250/21
摘要： The invention relates pharmaceutical/dietary supplement/food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.
摘要翻译： 本发明涉及选自提取物，级分，活性化合物和植物化学物质的衍生自Sphaeranthus indicus及其组合物的药物/膳食补充剂/食物成分，优选组合 与至少一种选自提取物，级分，活性化合物和植物化学物质的组分或其混合物衍生自芒of藤（Garcinia mangostana）。 成分和组成可用于控制，预防和治疗肥胖症，代谢综合征，糖尿病和其他代谢紊乱，并且还调节能量消耗，预防冠状动脉和腹主动脉中的动脉粥样硬化斑块，增加胰岛素 敏感性，改善葡萄糖耐量，降低甘油三酯水平和平衡哺乳动物中的葡萄糖水平。
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公开(公告)号：US08541383B2
公开(公告)日：2013-09-24
申请号：US12784295
申请日：2010-05-20
申请人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswara Rao Chirravuri , Venkateswarlu Somepalli , Kiran Bhupathiraju
发明人： Ganga Raju Gokaraju , Rama Raju Gokaraju , Trimurtulu Golakoti , Venkateswara Rao Chirravuri , Venkateswarlu Somepalli , Kiran Bhupathiraju
CPC分类号： A61Q19/06 , A61K8/602 , A61K8/97 , A61K36/185 , A61K36/75 , A61K36/9066 , A61K2800/782 , A61K2300/00
摘要： Synergistic anti-adipogenic and pro-lipolytic compositions for the prevention and amelioration of adipogenesis and lipolysis mediated diseases, comprising at least two extracts selected from enriched demethylated curcuminoids obtained from Curcuma longa, Moringa oleifera and Murraya koenigii. The anti-adipogenic and pro-lipolytic compositions optionally contain one or more anti-obesic agents. These compositions are useful for preventing anti-inflammatory and free radical mediated diseases.
摘要翻译： 用于预防和改善脂肪生成和脂肪分解介导的疾病的协同的抗脂肪生成和促脂肪分解组合物，其包含至少两种提取物，其选自从姜黄，甘草和Murraya koenigii获得的富集的去甲基化姜黄素。 抗脂肪生成和促脂解组合物任选地含有一种或多种抗痴呆剂。 这些组合物可用于预防抗炎和自由基介导的疾病。
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