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公开(公告)号：US20070072238A1
公开(公告)日：2007-03-29
申请号：US11515500
申请日：2006-09-01
申请人： Ramesh Bhat
发明人： Ramesh Bhat
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/71 , G01N33/74 , G01N2500/00
摘要： The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer.
摘要翻译： 本发明涉及一种Wnt卷曲的嵌合体。 本发明还涉及可以使用Wnt-Frizzled嵌合体进行筛选或显影的药物组合物。 本发明的方法和药物组合物可用于治疗骨病和癌症。
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公开(公告)号：US07959112B2
公开(公告)日：2011-06-14
申请号：US11642266
申请日：2006-12-20
申请人： Arvind Kumar Tiwari , Ramasamy Anbarasu , Ramesh Bhat , Somakumar Ramachandrapanicker , Vageesh Kubatoor Patil , Carlo Becheri , Stefano Orlandi , Fabio Biondi , Lorenzo Chiosi
发明人： Arvind Kumar Tiwari , Ramasamy Anbarasu , Ramesh Bhat , Somakumar Ramachandrapanicker , Vageesh Kubatoor Patil , Carlo Becheri , Stefano Orlandi , Fabio Biondi , Lorenzo Chiosi
IPC分类号： B61L11/00
摘要： A system for detecting and classifying a wheel of a rail vehicle traveling on a railway track includes a plurality of wheel detectors coupled to one rail of the railway track and configured to detect presence of the wheel and to generate signals representative thereof. A processing system is coupled to the wheel detectors and configured to receive and process the signals. The processing system is configured to classify the wheel based on a speed independent classification value calculated based on the signals from the wheel detectors.
摘要翻译： 用于检测和分类在铁路车辆上行驶的轨道车辆的车轮的系统包括多个车轮检测器，其耦合到铁路轨道的一个轨道并且被配置为检测车轮的存在并产生表示其的信号。 处理系统耦合到车轮检测器并且被配置为接收和处理信号。 该处理系统被配置为基于基于来自车轮检测器的信号计算的与速度无关的分类值来对车轮进行分类。
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公开(公告)号：US20080149782A1
公开(公告)日：2008-06-26
申请号：US11642266
申请日：2006-12-20
申请人： Arvind Kumar Tiwari , Ramasamy Anbarasu , Ramesh Bhat , Somakumar Ramachandrapanicker , Vageesh Kubatoor Patil , Carlo Becheri , Stefano Orlandi , Fabio Biondi , Lorenzo Chiosi
发明人： Arvind Kumar Tiwari , Ramasamy Anbarasu , Ramesh Bhat , Somakumar Ramachandrapanicker , Vageesh Kubatoor Patil , Carlo Becheri , Stefano Orlandi , Fabio Biondi , Lorenzo Chiosi
IPC分类号： B61L13/04
摘要： A system for detecting and classifying a wheel of a rail vehicle traveling on a railway track includes a plurality of wheel detectors coupled to one rail of the railway track and configured to detect presence of the wheel and to generate signals representative thereof. A processing system is coupled to the wheel detectors and configured to receive and process the signals. The processing system is configured to classify the wheel based on a speed independent classification value calculated based on the signals from the wheel detectors.
摘要翻译： 用于检测和分类在铁路车辆上行驶的轨道车辆的车轮的系统包括多个车轮检测器，其耦合到铁路轨道的一个轨道并且被配置为检测车轮的存在并产生表示其的信号。 处理系统耦合到车轮检测器并且被配置为接收和处理信号。 该处理系统被配置为基于基于来自车轮检测器的信号计算的与速度无关的分类值来对车轮进行分类。
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4.发明申请Pharmaceutical compositions and methods of using secreted frizzled related protein 审中-公开使用分泌性卷曲相关蛋白的药物组合物和方法公开(公告)号：US20070072239A1
公开(公告)日：2007-03-29
申请号：US11515501
申请日：2006-09-01
申请人： Ramesh Bhat , Peter Bodine
发明人： Ramesh Bhat , Peter Bodine
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C12N5/08
CPC分类号： C07K14/71 , G01N33/74 , G01N2500/00
摘要： Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be used to identify compounds which target the Wnt-antagonizing function of an SFRP by way of one or more domains or specific amino acids. Pharmaceutical compositions can be prepared using these compounds, and bone disorders can be treated using these pharmaceutical compositions.
摘要翻译： 公开了用于调节SFRP（分泌的卷曲相关蛋白）的哺乳动物骨形成活性的方法和药物组合物。 SFRP是Wnts的分泌受体，其是已知调节基本生物学过程如组织极性，胚胎发育和肿瘤发生的重要多肽生长因子。 方法可用于鉴定通过一个或多个结构域或特定氨基酸靶向SFRP的Wnt拮抗功能的化合物。 可以使用这些化合物制备药物组合物，并且可以使用这些药物组合物治疗骨骼疾病。
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公开(公告)号：US20060025580A1
公开(公告)日：2006-02-02
申请号：US11026800
申请日：2004-12-30
CPC分类号： C07K14/70567
摘要： The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-β (hERβ), which comprises 530 amino acids. The invention also provides isolated hERβ polypeptides and hERβ-reactive antibodies, including those that specifically recognize amino acids 1-45 of hERβ. The invention also encompasses methods for identifying hERβ-interactive compounds, including agonists, antagonists, and co-activators.
摘要翻译： 本发明提供编码全长人雌激素受体-β（hERbeta）的分离的核酸，其包含530个氨基酸。 本发明还提供了分离的hERbeta多肽和hERbeta反应性抗体，包括特异性识别hERβ的氨基酸1-45的那些。 本发明还包括用于鉴定hERβ-交互化合物的方法，包括激动剂，拮抗剂和共激活剂。
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