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    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    4.
    发明申请
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
    用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物

    公开(公告)号：US20090105334A1

    公开(公告)日：2009-04-23

    申请号：US11442445

    申请日：2006-05-26

    申请人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

    发明人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

    IPC分类号： A61K31/27 ,  A61P25/06

    CPC分类号： A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个 至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain
    6.
    发明授权
    Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 失效
    用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物

    公开(公告)号：US07087643B2

    公开(公告)日：2006-08-08

    申请号：US10869406

    申请日：2004-06-16

    申请人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

    发明人： Ellen C. Codd ,  Carlos R. Plata-Salaman ,  Boyu Zhao

    IPC分类号： A00N47/10 ,  A61K31/27

    CPC分类号： A61K31/27

    摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1–C4 alkyl; wherein C1–C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1–C4 alkyl, C1–C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个 至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4各自独立地选自氢和C 1个C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1〜 C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

    Methods of treating epileptogenesis
    9.
    发明申请
    Methods of treating epileptogenesis 审中-公开
    治疗癫痫发生的方法

    公开(公告)号：US20070021501A1

    公开(公告)日：2007-01-25

    申请号：US11481626

    申请日：2006-07-06

    申请人： Roy Twyman ,  Boyu Zhao

    发明人： Roy Twyman ,  Boyu Zhao

    IPC分类号： A61K31/325

    CPC分类号： A61K31/27 ,  A61K31/325 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention is directed to methods for preventing, treating, reversing, inhibiting, or arresting epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof,: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

    摘要翻译： 本发明涉及用于预防，治疗，逆转，抑制或阻止受试者中癫痫发生的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物 ）或其药学上可接受的盐或酯，其中苯基在X上被一至五个选自氟，氯，溴和碘的卤素原子取代; 和R 1，R 2，R 3，R 4，R 5和/或 和R 6和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 6烷基的取代基取代， C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。