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公开(公告)号：US5885279A
公开(公告)日：1999-03-23
申请号：US476917
申请日：1995-06-07
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
CPC分类号： A61F9/00736 , A61B18/14 , A61B18/1402 , A61B18/148 , A61B2017/00084 , A61B2018/046 , A61F2009/00887 , A61F9/008
摘要： An apparatus for destroying residual lens epithelial cells. The apparatus includes a probe configured for insertion into the eye between the iris and the lens capsule. The probe is further configured to deliver energy therefrom to residual lens epithelial cells within the lens capsule in order to destroy them. The distal end of the probe is configured to allow a surgeon using the probe to reach all areas within the lens capsule to ensure that no epithelial cells remain alive after use of the probe.
摘要翻译： 一种破坏残余晶状体上皮细胞的装置。 该装置包括构造成用于插入到虹膜和透镜囊之间的眼睛中的探针。 该探针进一步构造成将能量从该透镜胶囊中的残余晶状体上皮细胞传递以将其消灭。 探针的远端被配置为允许使用探针的外科医生到达透镜囊内的所有区域，以确保在使用探针之后没有上皮细胞保持活着。
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公开(公告)号：US6138680A
公开(公告)日：2000-10-31
申请号：US14492
申请日：1998-01-28
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
IPC分类号： A61K9/08 , A61K31/715 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/22 , A61K38/43 , A61K47/48 , A61P27/02 , A61P43/00 , C08B37/00 , A61B19/00 , A01N37/18 , A01N43/04 , A01N38/00
CPC分类号： B82Y5/00 , A61K47/48315 , A61K47/48353
摘要： A method for destroying retinal pigment epithelial cells in an eye in order to prevent the occurrence of proliferative vitreoretinopathy. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the vitreous chamber. The solution is maintained in the vitreous chamber for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes lining the vitreous chamber. The solution is then removed from the vitreous chamber, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the vitreous chamber, thereby exposing retinal pigment epithelial cells disposed on the basement membrane to the cytotoxic agent.
摘要翻译： 一种破坏视网膜色素上皮细胞的方法，以防止增生性玻璃体视网膜病变的发生。 将含有与细胞毒性剂缀合的基底膜结合剂的溶液引入玻璃体腔。 将溶液保持在玻璃体腔中足以允许基底膜结合剂与衬里玻璃体腔室的基底膜结合的时间。 然后将溶液从玻璃体腔中除去，由此基底膜结合剂的一部分保持结合到玻璃体腔内的基底膜，从而将设置在基底膜上的视网膜色素上皮细胞暴露于细胞毒性剂。
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公开(公告)号：US6106554A
公开(公告)日：2000-08-22
申请号：US257678
申请日：1999-02-25
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/416 , A61L2300/802 , A61L2430/16
摘要： A surface treated intraocular lens implant for use in the replacement of a cataracts natural lens to prevent posterior cellular opacification. The surface treated intraocular lens includes one or more carbohydrates covalently bound to the surface of the intraocular lens implant and a carbohydrate binding agent conjugated to a cytotoxic agent for binding said carbohydrates. The cytotoxic agent present on the intraocular lens implant serves to destroy residual lens epithelial cells within the lens capsule thereby preventing posterior cellular opacification of the intraocular lens implant.
摘要翻译： 用于替代白内障天然晶状体的表面处理的眼内晶状体植入物，以防止后部细胞不透明。 表面处理的眼内透镜包括共价结合到眼内透镜植入物的表面的一种或多种碳水化合物和与细胞毒性剂缀合的碳水化合物结合剂，用于结合所述碳水化合物。 存在于眼内透镜植入物上的细胞毒性剂用于破坏晶状体囊内的残余晶状体上皮细胞，从而防止眼内透镜植入物的后细胞混浊。
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公开(公告)号：US5620013A
公开(公告)日：1997-04-15
申请号：US326991
申请日：1994-10-21
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
CPC分类号： A61K47/48315 , A61K47/48238
摘要： A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the lens capsule. The solution is maintained in the lens capsule for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes within the lens capsule. The solution is then removed from the lens capsule, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the lens capsule, thereby exposing residual lens epithelial cells disposed on the basement membrane to the cytotoxic agent.
摘要翻译： 一种消除眼中残留的晶状体上皮细胞的方法，以防止后房不透明化的发生。 将包含与细胞毒性剂缀合的基底膜结合剂的溶液引入镜片胶囊中。 将溶液保持在晶状体胶囊中足以允许基底膜结合剂结合透镜胶囊内的基底膜的时间。 然后将溶液从透镜胶囊中取出，由此基底膜结合剂的一部分保持结合到晶状体胶囊内的基底膜，从而将设置在基底膜上的残余晶状体上皮细胞暴露于细胞毒性剂。
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公开(公告)号：US5445636A
公开(公告)日：1995-08-29
申请号：US162688
申请日：1993-12-06
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
IPC分类号： A61B17/00 , A61B18/04 , A61B18/14 , A61F9/007 , A61F9/011 , A61M1/00 , A61B17/20 , A61B17/28
CPC分类号： A61F9/00736 , A61B18/14 , A61B18/1402 , A61B18/148 , A61B2017/00084 , A61B2018/046 , A61F2009/00887 , A61F9/008
摘要： A method and apparatus for preventing posterior capsular opacification. The apparatus includes a probe configured for insertion into the lens capsule of an eye undergoing extracapsular cataract extraction. The probe is further configured to deliver energy therefrom to tissues within the lens capsule in order to kill residual lens epithelial cells. The method includes the steps of inserting a probe constructed in accordance with the apparatus of present invention into the lens capsule of the eye, delivering energy to the probe such that residual lens epithelial cells within the lens capsule are killed, ceasing the delivery of energy to the probe, and removing the probe from the eye.
摘要翻译： 一种防止后囊膜混浊的方法和装置。 该装置包括构造成用于插入进行囊外白内障摘除的眼睛的透镜胶囊中的探针。 探针进一步构造成将能量从该透镜胶囊中的组织输送，以便杀死残余的晶状体上皮细胞。 该方法包括将根据本发明的装置构建的探针插入眼睛的晶状体囊中的步骤，将能量传递到探针，使得晶状体囊内的残余晶状体上皮细胞死亡，停止将能量传递到 探头，并从眼睛上取下探头。
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公开(公告)号：US06454802B1
公开(公告)日：2002-09-24
申请号：US09642966
申请日：2000-08-21
IPC分类号： A61F216
CPC分类号： A61L27/50 , A61F2/16 , A61F2002/009 , A61F2002/1699 , A61L2400/18
摘要： A surface treated intraocular lens implant for use in the replacement of a cataractous natural lens to prevent posteriror capsular opacification. The surface treated intraocular lens includes one or more proteins, polypeptides, polyamino acids or polyamines bound to the surface of the intraocular lens implant covalently, non-covalently or a combination thereof. The one or more proteins, polypeptides, polyamino acids or polyamines present on the surface of the intraocular lens implant serves to reduce or eliminate residual lens epithelial cell migration within the lens capsule. By preventing residual lens epithelial cell migration, posterior capsular opacification of the intraocular lens implant is thus reduced or eliminated.
摘要翻译： 一种表面处理的眼内晶状体植入物，用于替代白内障天然晶状体以防止后囊膜混浊。 表面处理的眼内透镜包括共价，非共价或其组合结合到眼内透镜植入体表面的一种或多种蛋白质，多肽，聚氨基酸或多胺。 存在于眼内透镜植入物的表面上的一种或多种蛋白质，多肽，聚氨基酸或多胺用于减少或消除晶状体囊内剩余的晶状体上皮细胞迁移。 通过防止残留的晶状体上皮细胞迁移，因此减少或消除了眼内透镜植入物的后囊膜混浊。
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公开(公告)号：US06089234A
公开(公告)日：2000-07-18
申请号：US784429
申请日：1997-01-16
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
CPC分类号： A61K47/48315 , A61K47/48238
摘要： A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the lens capsule. The solution is maintained in the lens capsule for a period of time sufficient to permit the basement membrane binding agent to bind to basement membranes within the lens capsule. The solution is then removed from the lens capsule, whereby a portion of the basement membrane binding agent remains bonded to basement membranes within the lens capsule, thereby exposing residual lens epithelial cells disposed on the basement membrane to the cytotoxic agent.
摘要翻译： 一种消除眼中残留的晶状体上皮细胞的方法，以防止后房不透明化的发生。 将包含与细胞毒性剂缀合的基底膜结合剂的溶液引入镜片胶囊中。 将溶液保持在晶状体胶囊中足以允许基底膜结合剂结合透镜胶囊内的基底膜的时间。 然后将溶液从透镜胶囊中取出，由此基底膜结合剂的一部分保持结合到晶状体胶囊内的基底膜，从而将设置在基底膜上的残余晶状体上皮细胞暴露于细胞毒性剂。
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公开(公告)号：US5445637A
公开(公告)日：1995-08-29
申请号：US301465
申请日：1994-09-07
申请人： Randolph H. Bretton
发明人： Randolph H. Bretton
IPC分类号： A61B17/00 , A61B18/04 , A61B18/14 , A61F9/007 , A61F9/011 , A61M1/00 , A61B17/20 , A61B17/28
CPC分类号： A61F9/00736 , A61B18/14 , A61B18/1402 , A61B18/148 , A61B2017/00084 , A61B2018/046 , A61F2009/00887 , A61F9/008
摘要： A method and apparatus for destroying residual lens epithelial cells. The apparatus includes a probe configured for insertion into the eye between the iris and the lens capsule. The probe is further configured to deliver energy therefrom to residual lens epithelial cells within the lens capsule in order to destroy them. The method includes the steps of inserting a probe constructed in accordance with the apparatus of present invention into the eye such that a distal end portion of the probe is disposed between the iris and the lens capsule, delivering energy to the probe such that residual lens epithelial cells within the lens capsule are destroyed, ceasing the delivery of energy to the probe, and removing the probe from the eye.
摘要翻译： 一种破坏残余晶状体上皮细胞的方法和装置。 该装置包括构造成用于插入到虹膜和透镜囊之间的眼睛中的探针。 该探针进一步构造成将能量从该透镜胶囊中的残余晶状体上皮细胞传递以将其消灭。 该方法包括以下步骤：将根据本发明的装置构造的探针插入到眼睛中，使得探针的远端部分设置在虹膜和透镜囊之间，将能量传递到探针，使得残余的晶状体上皮 晶状体囊内的细胞被破坏，停止向探针传递能量，并从眼睛移除探针。
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