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公开(公告)号：US5856122A
公开(公告)日：1999-01-05
申请号：US292968
申请日：1994-08-22
申请人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
发明人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
IPC分类号： C07K14/235 , G01N33/566 , G01N33/68 , C12P21/02
CPC分类号： C07K14/235 , G01N33/566 , G01N33/6893
摘要： The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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公开(公告)号：US5977304A
公开(公告)日：1999-11-02
申请号：US467536
申请日：1995-06-06
申请人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
发明人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
IPC分类号： C07K14/235 , G01N33/566 , G01N33/68 , C07K1/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/235 , G01N33/566 , G01N33/6893
摘要： The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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公开(公告)号：US5965385A
公开(公告)日：1999-10-12
申请号：US467974
申请日：1995-06-06
申请人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
发明人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
IPC分类号： C07K14/235 , G01N33/566 , G01N33/68 , C12P21/06 , C07H21/04 , C07K1/00 , C12N1/20
CPC分类号： C07K14/235 , G01N33/566 , G01N33/6893
摘要： The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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公开(公告)号：US06168928A
公开(公告)日：2001-01-02
申请号：US09082514
申请日：1998-05-21
申请人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
发明人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
IPC分类号： C12N910
CPC分类号： C07K14/235 , G01N33/566 , G01N33/6893
摘要： The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
摘要翻译： 结晶百日咳全毒素（PT）的三维结构已经通过X射线晶体学确定。 也已经确定了百日咳毒素与PT生物活性相关分子的复合物的晶体结构。 分析这些三维结构以鉴定适于修饰以改变PT的生物学性质的功能性氨基酸。 类似的程序可用于预测有助于全毒素毒性的氨基酸，产生免疫保护，百日咳毒素的遗传解毒类似物。
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公开(公告)号：US6018022A
公开(公告)日：2000-01-25
申请号：US467976
申请日：1995-06-06
申请人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
发明人： Randy J. Read , Penelope E. Stein , Stephen A. Cockle , Raymond P. Oomen , Sheena Loosmore , Michel H. Klein , Glen D. Armstrong , Bart Hazes
IPC分类号： C07K14/235 , G01N33/566 , G01N33/68 , C07K1/00 , A61K39/10 , A61K39/108 , C12P21/06
CPC分类号： C07K14/235 , G01N33/566 , G01N33/6893
摘要： The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
摘要翻译： 结晶百日咳全毒素（PT）的三维结构已经通过X射线晶体学确定。 也已经确定了百日咳毒素与PT生物活性相关分子的复合物的晶体结构。 分析这些三维结构以鉴定适于修饰以改变PT的生物学性质的功能性氨基酸。 类似的程序可用于预测有助于全毒素毒性的氨基酸，产生免疫保护，百日咳毒素的遗传解毒类似物。
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公开(公告)号：US6107282A
公开(公告)日：2000-08-22
申请号：US419790
申请日：1999-10-18
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： A61K31/70 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K47/48 , A61P1/04 , A61P1/12 , A61P39/02
CPC分类号： A61K47/48861 , A61K31/715 , A61K47/48092 , Y10S514/867
摘要： This invention relates to prevention and/or treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC) and other conditions associated with C. difficile infection, using oligosaccharide compositions which bind C. difficile toxin B. More specifically, the invention concerns neutralization of C. difficile toxin B associated with such conditions.
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公开(公告)号：US6013635A
公开(公告)日：2000-01-11
申请号：US85032
申请日：1998-05-28
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
IPC分类号： A61K31/70 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K47/48 , A61P1/04 , A61P1/12 , A61P39/02
CPC分类号： A61K47/48861 , A61K31/715 , A61K47/48092 , Y10S514/867
摘要： This invention relates to prevention and/or treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC) and other conditions associated with C. difficile infection, using oligosaccharide compositions which bind C. difficile toxin B. More specifically, the invention concerns neutralization of C. difficile toxin B associated with such conditions.
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公开(公告)号：US5679653A
公开(公告)日：1997-10-21
申请号：US453775
申请日：1995-05-30
IPC分类号： A61K38/00 , A61K47/48 , A61P31/04 , C07K14/245 , G01N33/569 , A61K31/70
CPC分类号： C07K14/245 , G01N33/56916 , A61K38/00 , G01N2469/00
摘要： Diagnostic and therapeutic compositions which comprise the .alpha.Gal(1-4).beta.Gal subunit are described. These compositions permit the rapid diagnosis and treatment of enteric infections caused by E. coli that produce shiga-like toxins (SLT).
摘要翻译： 描述了包含αGal（1-4）βGal亚基的诊断和治疗组合物。 这些组合物允许快速诊断和治疗由产生志贺样毒素（SLT）的大肠杆菌引起的肠道感染。
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公开(公告)号：US5637576A
公开(公告)日：1997-06-10
申请号：US461625
申请日：1995-06-05
申请人： Louis D. Heerze , Glen D. Armstrong
发明人： Louis D. Heerze , Glen D. Armstrong
CPC分类号： A61K47/48861 , Y10S514/867 , Y10S514/946 , Y10S514/965
摘要： This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxogenic Escherichia coli (ETEC), using an oligosaccharide-containing composition. The composition contains an oligosaccharide sequence covalently attached to a pharmaceutically acceptable solid, inert support through a non-peptidyl compatible linker arm. The oligosaccharide-containing composition binds E. coli heat-labile toxin (LT). More specifically, the invention concerns neutralization and removal of LT associated with traveller's diarrhea.
摘要翻译： 本发明涉及使用含寡糖组合物治疗旅行者腹泻的治疗方法，包括肠道致毒性大肠杆菌（ETEC）引起的腹泻。 该组合物含有通过非肽基相容的连接臂共价连接到药学上可接受的固体惰性支持物上的寡糖序列。 含有寡糖的组合物结合大肠杆菌热不稳定毒素（LT）。 更具体地，本发明涉及与旅行者腹泻相关的LT的中和和去除。
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公开(公告)号：US5620858A
公开(公告)日：1997-04-15
申请号：US126645
申请日：1993-09-27
IPC分类号： A61K38/00 , A61K47/48 , A61P31/04 , C07K14/245 , G01N33/569 , G01N33/53 , C07K14/25 , C07K1/22
CPC分类号： C07K14/245 , G01N33/56916 , A61K38/00 , G01N2469/00
摘要： Diagnostic and therapeutic compositions which comprise the .alpha.Gal(1-4).beta.Gal subunit are described. These compositions permit the rapid diagnosis and treatment of enteric infections caused by E. coli that produce shiga-like toxins (SLT).
摘要翻译： 描述了包含αGal（1-4）βGal亚基的诊断和治疗组合物。 这些组合物允许快速诊断和治疗由产生志贺样毒素（SLT）的大肠杆菌引起的肠道感染。
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