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22 条记录 (耗时 0.022 秒)

    Phenalkoxyalkyl- and phenoxyalkyl-substituted oxiranecarboxylic acids, their use and medicaments containing them
    8.
    发明授权
    Phenalkoxyalkyl- and phenoxyalkyl-substituted oxiranecarboxylic acids, their use and medicaments containing them 失效
    苯氧基烷基和苯氧基烷基取代的环氧乙烷羧酸，它们的用途和含有它们的药物

    公开(公告)号：US4337267A

    公开(公告)日：1982-06-29

    申请号：US250627

    申请日：1981-04-03

    申请人： Klaus Eistetter ,  Erich Rapp

    发明人： Klaus Eistetter ,  Erich Rapp

    IPC分类号： C07D303/48 ,  A61K31/335 ,  A61K31/336 ,  A61P3/08 ,  A61P3/10 ,  C07C29/147 ,  C07C29/36 ,  C07C43/174 ,  C07C43/178 ,  C07C43/225 ,  C07C43/29 ,  C07D303/00

    CPC分类号： C07C29/147 ,  C07C29/36 ,  C07C43/174 ,  C07C43/178 ,  C07C43/225 ,  C07C43/29

    摘要： Phenalkoxyalky- and phenoxyalkyl-substituted oxiranecarboxylic acids of the formula ##STR1## wherein R.sup.1 denotes a hydrogen atom (--H), a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group or a trifluoromethyl group,R.sup.2 has one of the meanings of R.sup.1,R.sup.3 denotes a hydrogen atom (--H) or a lower alkyl group,Y denotes --O--(CH.sub.2).sub.m --,m denotes O or an integer from 1 to 4, andn denotes an integer from 2 to 8, with the proviso that the sum of m and n is an integer from 2 to 8,and the salts of the acids are new compounds. They display a hypoglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds and of the intermediate products required for their preparation are described.

    摘要翻译： 式（I）的烷基氧基和苯氧基烷基取代的环氧乙烷羧酸，其中R 1表示氢原子（-H），卤素原子，低级烷基，低级烷氧基，硝基或三氟甲基， R2具有R 1的含义之一，R 3表示氢原子（-H）或低级烷基，Y表示-O-（CH 2）m - ，m表示0或1〜4的整数，n表示 2至8的整数，条件是m和n的和为2至8的整数，并且酸的盐是新的化合物。 他们在温血动物中显示低血糖作用。 描述了制备新化合物及其制备所需的中间产物的方法。

    2-(Optionally-substituted)benzylperhydroazepines for analgesia and lowering blood pressure
    9.
    发明授权
    2-(Optionally-substituted)benzylperhydroazepines for analgesia and lowering blood pressure 失效
    2-（任选取代的）苄基双氢吖庚因用于镇痛和降低血压

    公开(公告)号：US4221788A

    公开(公告)日：1980-09-09

    申请号：US819453

    申请日：1977-07-27

    申请人： Klaus Eistetter

    发明人： Klaus Eistetter

    IPC分类号： C07D223/04 ,  C07D223/10 ,  C07D223/12 ,  A61K31/395

    CPC分类号： C07D223/10 ,  C07D223/04 ,  C07D223/12

    摘要： Title compounds and their acid-addition salts are physiologically acceptable or are readily converted to physiologically-acceptable counterparts by established procedures. They are pharmacologically active on the central nervous system (CNS) and are thus useful, when administered to warm-blooded animals, to induce central stimulation, to increase vigilance and to promote normal and pathologically-inhibited drive. They are also useful as analgesics and as blood-pressure-reducing agents for warm-blooded animals. These compounds are prepared, e.g., by reducing an appropriate 2-benzylazacycloheptane and are compounded into normal dosage-form medicament compositions.

    摘要翻译： 标题化合物及其酸加成盐是生理上可接受的或通过既定的方法容易地转化成生理上可接受的对应物。 它们在中枢神经系统（CNS）上具有药理活性，因此当对温血动物施用时，可用于诱导中枢刺激，增加警惕性并促进正常和病理学抑制的驱动。 它们也可用作止血剂和作为温血动物的减压剂。 这些化合物例如通过还原合适的2-苄基氮杂环庚烷并且被配成正常的剂型药物组合物来制备。

    Anti-depressant and analgesic 4-phenoxypiperidines
    10.
    发明授权
    Anti-depressant and analgesic 4-phenoxypiperidines 失效
    抗抑郁和止痛4-苯氧基哌啶

    公开(公告)号：US4333942A

    公开(公告)日：1982-06-08

    申请号：US167628

    申请日：1980-07-11

    申请人： Klaus Eistetter ,  Hans-Peter Kley ,  Heinz-Gunter Menge ,  Hartmann Schaefer

    发明人： Klaus Eistetter ,  Hans-Peter Kley ,  Heinz-Gunter Menge ,  Hartmann Schaefer

    IPC分类号： A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61P25/04 ,  A61P25/20 ,  C07D211/48 ,  C07D211/52 ,  C07D211/94

    CPC分类号： C07D211/48 ,  C07D211/52 ,  C07D211/94

    摘要： 4-Phenoxypiperidines of the general formula I ##STR1## wherein R.sup.1 denotes a hydrogen atom, an alkyl group with 1 to 5 carbon atoms, an alkenyl group with 3 to 5 carbon atoms, a cycloalkylmethyl group with 3 to 7 carbon atoms in the cycloalkyl part or a phenylalkyl group with 1 to 3 carbon atoms in the alkyl part,R.sup.2 denotes a hydrogen atom, a nitro group, an amino group or an acylamino group andR.sup.3 denotes a phenyl group or a benzyl group,and their N-oxides and their acid-addition salts are new compounds. They have an antiptotic and analgesic action and are suitable for the treatment of depressions and painful conditions. Processes for the preparation of the new compounds are provided.

    摘要翻译： 通式I的4-苯氧基哌啶其中R 1表示氢原子，具有1至5个碳原子的烷基，具有3至5个碳原子的烯基，具有3至7个碳原子的环烷基甲基 在烷基部分的环烷基部分或具有1〜3个碳原子的苯基烷基中，R2表示氢原子，硝基，氨基或酰氨基，R3表示苯基或苄基，它们的N 氧化物及其酸加成盐是新的化合物。 它们具有止痛和镇痛作用，适用于治疗沮丧和痛苦的病症。 提供了制备新化合物的方法。