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1.发明申请DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开通过从混合样品中定量鉴定基因组DNA来确定天然异构体公开(公告)号：US20130288242A1
公开(公告)日：2013-10-31
申请号：US13738268
申请日：2013-01-10
IPC分类号： C12Q1/68
CPC分类号： G01N1/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。
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公开(公告)号：US20130189689A1
公开(公告)日：2013-07-25
申请号：US13837974
申请日：2013-03-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US08168389B2
公开(公告)日：2012-05-01
申请号：US12230628
申请日：2008-09-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20130189688A1
公开(公告)日：2013-07-25
申请号：US13835926
申请日：2013-03-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US08137912B2
公开(公告)日：2012-03-20
申请号：US11763245
申请日：2007-06-14
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N1/30 , G01N33/6893 , G01N2800/385
摘要： The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.
摘要翻译： 本发明涉及用于检测，富集和分析存在于血液中的罕见细胞的方法，例如， 胎儿细胞。 本发明还涉及分析稀有细胞以确定受试者中异常，疾病或病症的存在的方法，例如， 通过分析来自受试者的细胞样品的胎儿。
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6.发明申请DETERMINATION OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开通过从混合样品中定量鉴定基因组DNA来确定天然异构体公开(公告)号：US20120183963A1
公开(公告)日：2012-07-19
申请号：US13433232
申请日：2012-03-28
申请人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
发明人： Roland Stoughton , Ravi Kapur , Mehmet Toner , Daniel Shoemaker , Ronald W. Davis , Barb Ariel Cohen
IPC分类号： C12Q1/68
CPC分类号： G01N1/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G16B20/00
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。
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公开(公告)号：US08372584B2
公开(公告)日：2013-02-12
申请号：US11763421
申请日：2007-06-14
申请人： Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
发明人： Daniel Shoemaker , Mehmet Toner , Ravi Kapur , Roland Stoughton
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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公开(公告)号：US20080220422A1
公开(公告)日：2008-09-11
申请号：US11763421
申请日：2007-06-14
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20100136529A1
公开(公告)日：2010-06-03
申请号：US12230628
申请日：2008-09-02
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravi Kapur , Zihua Wang
CPC分类号： C12Q1/6881 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常的系统，装置和方法，例如， 非整倍体 本发明涉及用不同的标记标记所述混合样品中每个细胞中的基因组DNA的区域，其中每个标记对每个细胞是特异性的，并且定量混合样品中每个细胞的基因组DNA的标记区域。 更具体地，本发明涉及从混合样品中的每个细胞定量标记的DNA多态性。
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公开(公告)号：US20120171666A1
公开(公告)日：2012-07-05
申请号：US13306640
申请日：2011-11-29
申请人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravl Kapur , Zihua Wang
发明人： Daniel Shoemaker , Martin Fuchs , Neil X. Krueger , Mehmet Toner , Darren Gray , Ravl Kapur , Zihua Wang
IPC分类号： G01N27/62
CPC分类号： C12Q1/6883 , B01L3/502761 , C12Q1/6809 , C12Q1/6869 , C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N2015/1006 , G01N2015/1087 , Y10T436/143333
摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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