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10 条记录 (耗时 0.037 秒)

    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS
    3.
    发明申请
    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS 审中-公开
    使用多态性诊断不良反应，包括短暂的重复

    公开(公告)号：US20110171638A1

    公开(公告)日：2011-07-14

    申请号：US12725240

    申请日：2010-03-16

    申请人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    发明人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    IPC分类号： C12Q1/68

    CPC分类号： G01N1/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。

    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS
    4.
    发明申请
    DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS 审中-公开
    使用多态性诊断不良反应，包括短暂的重复

    公开(公告)号：US20090280492A1

    公开(公告)日：2009-11-12

    申请号：US12413485

    申请日：2009-03-27

    申请人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    发明人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    IPC分类号： C12Q1/68

    CPC分类号： G01N1/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。

    DIAGNOSIS OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES
    7.
    发明申请
    DIAGNOSIS OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES 审中-公开
    通过从混合样品中定量鉴定基因组DNA来诊断子宫内膜异位症

    公开(公告)号：US20100291571A1

    公开(公告)日：2010-11-18

    申请号：US12751908

    申请日：2010-03-31

    申请人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    发明人： Roland Stoughton ,  Ravi Kapur ,  Barb Ariel Cohen

    IPC分类号： C12Q1/68

    CPC分类号： G01N1/30 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00

    摘要： The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.

    摘要翻译： 本发明提供了当与样品中的母体细胞群混合时检测胎儿细胞的存在并测试胎儿异常（即非整倍体）的系统，装置和方法。 此外，本发明提供了确定何时胎儿细胞不足以确定并报告非信息性病例的方法。 本发明涉及量化来自混合样品的基因组DNA的区域。 更具体地，本发明涉及从混合样品中定量DNA多态性。

    REAL TIME MULTIPOINT ASSAY FOR OPTIMIZING PERFORMANCE
    9.
    发明申请
    REAL TIME MULTIPOINT ASSAY FOR OPTIMIZING PERFORMANCE 审中-公开
    用于优化性能的实时多点测定

    公开(公告)号：US20120252000A1

    公开(公告)日：2012-10-04

    申请号：US13436701

    申请日：2012-03-30

    申请人： Barb Ariel Cohen

    发明人： Barb Ariel Cohen

    IPC分类号： C12N5/076

    CPC分类号： G01N33/5091 ,  G01N33/689 ,  G01N33/92 ,  G01N2333/47 ,  G01N2405/04 ,  G01N2800/367

    摘要： Described herein are methods of optimizing the performance of a mammalian semen sample with respect to outcomes such as fertility, using a multipoint assay to determine an optimum time point for preparing the semen sample for use in insemination. The multipoint assay is based upon a kinetic model of biomarker expression during sperm capacitation relative to the outcome of interest.

    摘要翻译： 本文描述的是使用多点测定来确定用于准备用于授精的精液样品的最佳时间点来优化哺乳动物精液样品在诸如生育力等结果方面的性能的方法。 多点测定是基于精子获能期间相对于感兴趣结果的生物标志物表达的动力学模型。

    Detection and removal of chitinous material in a biological sample
    10.
    发明授权
    Detection and removal of chitinous material in a biological sample 失效
    检测和去除生物样品中的几丁质物质

    公开(公告)号：US06833250B2

    公开(公告)日：2004-12-21

    申请号：US09759815

    申请日：2001-01-10

    申请人： Steven J. Potts ,  David C. Slaughter ,  James F. Thompson ,  Jennifer J. Payne ,  Barb Ariel Cohen

    发明人： Steven J. Potts ,  David C. Slaughter ,  James F. Thompson ,  Jennifer J. Payne ,  Barb Ariel Cohen

    IPC分类号： C12Q104

    CPC分类号： G01N33/56961 ,  C12Q1/34 ,  G01N33/5308 ,  G01N2333/42 ,  G01N2333/924 ,  G01N2400/28 ,  G01N2400/46

    摘要： This invention provides novel methods for the detection of chitinous contaminants of non-chitinous biological materials. The methods are accurate, highly reproducible, rapid and relatively inexpensive. The methods are well suited to commercial applications, particularly in the food and agriculture industry where biological materials (e.g. food products) are regularly screened for contaminants (e.g. insect, mold, fungus, etc.). In one embodiment, the methods involve contacting a biological sample with a probe that is a lectin that binds chitin, contacting the sample with a pectinase; and detecting binding of said lectin to a chitin where the binding indicates the presence of chitin in the biological sample.

    摘要翻译： 本发明提供了用于检测非壳质生物材料的几丁质污染物的新方法。 这些方法是准确的，高度可重复的，快速的和相对便宜的。 这些方法非常适合于商业应用，特别是在食品和农业行业，其中生物材料（例如食品）被定期筛选用于污染物（例如昆虫，霉菌，真菌等）。 在一个实施方案中，所述方法包括使生物样品与作为结合几丁质的凝集素的探针接触，使样品与果胶酶接触; 并检测所述凝集素与几丁质的结合，其中所述结合指示生物样品中几丁质的存在。