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公开(公告)号：US5970633A
公开(公告)日：1999-10-26
申请号：US186808
申请日：1998-11-05
CPC分类号： A43B3/0031 , A43B1/0036 , A43B5/1666 , A43B5/18
摘要： An overshoe construction (10) for athletic shoes (100) wherein the construction (10) includes a cover member (20) dimensioned to overlie the upper portion of the athletic shoe (100) and provided with an accessory unit (12) which includes a pocket member (30) and at least one strap member (32) adapted to releasably engage a miniature flashlight (50).
摘要翻译： 一种用于运动鞋（100）的套鞋结构（10），其中，所述构造（10）包括覆盖所述运动鞋（100）的上部并且设置有附件单元（12）的盖构件（20），所述附件单元包括 袋构件（30）和适于可释放地接合微型手电筒（50）的至少一个带构件（32）。
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公开(公告)号：US5736325A
公开(公告)日：1998-04-07
申请号：US299187
申请日：1994-08-31
申请人： Paul Manowitz , Ronald D. Poretz , David Park , Michael Ricketts
发明人： Paul Manowitz , Ronald D. Poretz , David Park , Michael Ricketts
CPC分类号： C12N9/16 , C07K16/40 , C12Q1/6883 , G01N33/573 , C12Q1/683 , C12Q2600/156 , C12Q2600/172 , Y10S435/81 , Y10S435/975
摘要： The present invention relates to methods for diagnosis of susceptibility to alcoholism or the pathological effects of alcoholism based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to alcoholism and/or susceptibility to alcohol's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
摘要翻译： 本发明涉及用于诊断酒精中毒易感性的方法或基于个体中遗传标记检测的酒精中毒的病理作用。 本发明一般涉及用于检测人类中芳基硫酸酯酶A（ASA）假性缺陷（PD）突变的存在的方法和相关组合物和试剂盒。 惊奇地发现这些突变的检测是对酒精中毒易感性和/或对酒精病理作用的易感性的强指示剂，以及评估异染色性脑白质营养不良（MLD）可能性的重要标志物。
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