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公开(公告)号：US12077782B2
公开(公告)日：2024-09-03
申请号：US17317602
申请日：2021-05-11
发明人： Jena Daya , Valerie Ann Cusick , John Mattila
CPC分类号： C12N7/00 , C07K1/14 , C07K16/1036 , C12N2740/13063
摘要： Methods for viral clearance using low pH hold based on a statistical design of experiment are provided. Several factors are evaluated to characterize the impacts of a low pH hold step for virus inactivation, including the factors of pH conditions, conductivity conditions, protein type, temperature, acid titrant, spike timing, and post-spike filtration. In addition to the effect of pH on virus inactivation, an increase in ionic strength through manipulating the conductivity can be a key component that influences virus inactivation kinetics.
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公开(公告)号：US20210348131A1
公开(公告)日：2021-11-11
申请号：US17317602
申请日：2021-05-11
发明人： Jena Daya , Valerie Ann Cusick , John Mattila
摘要： Methods for viral clearance using low pH hold based on a statistical design of experiment are provided. Several factors are evaluated to characterize the impacts of a low pH hold step for virus inactivation, including the factors of pH conditions, conductivity conditions, protein type, temperature, acid titrant, spike timing, and post-spike filtration. In addition to the effect of pH on virus inactivation, an increase in ionic strength through manipulating the conductivity can be a key component that influences virus inactivation kinetics.
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