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1.发明申请MAGNETIC DETECTION OF MERCURIC ION USING GIANT MAGNETORESISTIVE BASED BIOSENSING SYSTEM 审中-公开使用大量基于磁性的生物传感系统进行磁性离子检测公开(公告)号：US20160209405A1
公开(公告)日：2016-07-21
申请号：US14676620
申请日：2015-04-01
Applicant: Regents of the University of Minnesota
Inventor： Jian-Ping Wang , Wei Wang , Yi Wang , Todd Klein
IPC: G01N33/543 , G01N33/53 , G01R33/09
CPC classification number: G01N33/54326 , G01N33/84 , G01R33/0094 , G01R33/09 , G01R33/093 , G01R33/1269
Abstract: A system may include a magnetic sensor including a free magnetic layer and a fixed magnetic layer; a sample container disposed over the magnetic stack; a plurality of capture DNA oligomers on a surface of the magnetic biosensor within the volume defined by the sample container above the magnetic stack, wherein each of the plurality of capture DNA oligomers includes at least one thymine base configured to bind to an Hg2+ ion; a magnetic field generator configured to generate a magnetic field that influences the free layer; and circuitry configured to measure a resistance of the magnetic sensor.
Abstract translation: 系统可以包括包括自由磁性层和固定磁性层的磁传感器; 设置在所述磁性堆叠上的样品容器; 所述磁性生物传感器的表面上的多个捕获DNA寡聚体在由所述磁性堆叠物上方的所述样品容器限定的体积内，其中所述多个捕获DNA寡聚体中的每一个包含至少一个被配置为结合Hg 2+离子的胸腺嘧啶碱基; 磁场发生器，被配置为产生影响自由层的磁场; 以及被配置为测量磁传感器的电阻的电路。
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2.发明申请MAGNETIC BIOMEDICAL SENSORS AND SENSING SYSTEM FOR HIGH-THROUGHPUT BIOMOLECULE TESTING 有权用于高通量生物分子测试的磁性生物医学传感器和感测系统公开(公告)号：US20140292318A1
公开(公告)日：2014-10-02
申请号：US14352638
申请日：2012-10-19
Applicant: Regents of the University of Minnesota
Inventor： Jian-Ping Wang , Md Tofizur Rahman , Yi Wang
CPC classification number: G01R33/12 , B82Y25/00 , G01N27/72 , G01N35/0098 , G01R3/00 , G01R33/093 , G01R33/1269 , Y10T29/4902
Abstract: A magnetic biosensor can include a magnetic stack comprising a free layer, a fixed layer, and a nonmagnetic layer between the free layer and the fixed layer. At least one of the free layer or the fixed layer may have a magnetic moment oriented out of a major plane of the free layer or the fixed layer, respectively, in an absence of an external magnetic field. The magnetic biosensor also may include a sample container disposed over the magnetic stack, a plurality of capture antibodies attached to a bottom surface of the sample container above the magnetic stack, and a magnetic field generator configured to generate a magnetic field substantially perpendicular to the major plane of the free layer or fixed layer.
Abstract translation: 磁性生物传感器可以包括在自由层和固定层之间包括自由层，固定层和非磁性层的磁性堆叠。 在没有外部磁场的情况下，自由层或固定层中的至少一个可以分别具有定向在自由层或固定层的主平面外的磁矩。 磁性生物传感器还可以包括设置在磁性堆叠上的样品容器，附着到磁性堆叠上方的样品容器的底表面的多个捕获抗体，以及磁场发生器，其配置成产生基本上垂直于主体的磁场 平面的自由层或固定层。
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公开(公告)号：US09823316B2
公开(公告)日：2017-11-21
申请号：US14352638
申请日：2012-10-19
Applicant: Regents of the University of Minnesota
Inventor： Jian-Ping Wang , Md Tofizur Rahman , Yi Wang
CPC classification number: G01R33/12 , B82Y25/00 , G01N27/72 , G01N35/0098 , G01R3/00 , G01R33/093 , G01R33/1269 , Y10T29/4902
Abstract: A magnetic biosensor can include a magnetic stack comprising a free layer, a fixed layer, and a nonmagnetic layer between the free layer and the fixed layer. At least one of the free layer or the fixed layer may have a magnetic moment oriented out of a major plane of the free layer or the fixed layer, respectively, in an absence of an external magnetic field. The magnetic biosensor also may include a sample container disposed over the magnetic stack, a plurality of capture antibodies attached to a bottom surface of the sample container above the magnetic stack, and a magnetic field generator configured to generate a magnetic field substantially perpendicular to the major plane of the free layer or fixed layer.
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