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公开(公告)号:US09079958B2
公开(公告)日:2015-07-14
申请号:US13246022
申请日:2011-09-27
申请人: Renate Konopitzky , Eric Borges , Paul Adam , Karl-Heinz Heider
发明人: Renate Konopitzky , Eric Borges , Paul Adam , Karl-Heinz Heider
CPC分类号: C07K16/2803 , C07K16/2851 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要: The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS).
摘要翻译: 本发明涉及基于骨髓细胞消耗的免疫疗法。 特别地,本发明涉及用于此类疗法的CD33结合剂,例如, 治疗骨髓细胞恶性肿瘤和骨髓增生异常综合征(MDS)。
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公开(公告)号:US10179810B2
公开(公告)日:2019-01-15
申请号:US14304338
申请日:2014-06-13
IPC分类号: A61K39/395 , C07K16/22 , A61K31/282 , A61K33/24 , A61K45/06 , A61K31/436 , A61K31/517 , G01N33/574 , A61K39/00
摘要: Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
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公开(公告)号:US08318159B2
公开(公告)日:2012-11-27
申请号:US12636195
申请日:2009-12-11
申请人: Paul Adam , Eric Borges
发明人: Paul Adam , Eric Borges
IPC分类号: A61K39/395 , C07K16/26
CPC分类号: C07K16/22 , A61K31/282 , A61K31/436 , A61K31/517 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57496 , G01N2333/475 , G01N2800/52 , Y02A50/466 , A61K2300/00
摘要: Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
摘要翻译: 抗体分子,特别是与人IGF-1结合并与IGF-2交叉反应的完全人类抗体,使得IGF-1和IGF-2与IGF-1受体的结合被阻止,并且IGF-1受体介导的信号传导 被抑制。 抗体不结合胰岛素,因此不影响胰岛素与胰岛素受体结合介导的促有丝分裂特性。 抗体可用于治疗过度增生性疾病,特别是癌症。
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公开(公告)号:US08956139B2
公开(公告)日:2015-02-17
申请号:US14318048
申请日:2014-06-27
申请人: Paul Adam
发明人: Paul Adam
CPC分类号: B28B3/083 , A01G9/28 , B28B3/06 , B28B7/0097 , B28B7/24
摘要: A mold system for forming a multilevel block is disclosed which comprises a multilevel mold box insert for forming a multilevel block, a mold box frame adapted for receiving therein the multilevel mold box insert, a multilevel plunger assembly, and a press head plate adapted for receiving thereon the multilevel plunger assembly.
摘要翻译: 公开了一种用于形成多级块的模具系统,其包括用于形成多级块的多级模具盒插入件,适于在其中容纳多级模具盒插入件的多个模具箱框架,多级柱塞组件和适于接收 在其上的多级柱塞组件。
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公开(公告)号:US20060117697A1
公开(公告)日:2006-06-08
申请号:US10994859
申请日:2004-11-22
申请人: Paul Adam
发明人: Paul Adam
IPC分类号: E04C2/04
CPC分类号: E04C1/395 , E04B2002/0245 , E04B2002/026 , E04B2002/0263
摘要: A modular block system comprises a first block, a second block, a third block, a fourth block, and a capstone, the first block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side being slanted from the front face toward the back face, the second block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first and second sides being slanted from the front face toward the back face, the third block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side being slanted from the front face toward the back face, and the fourth block having a front face, a back face, a first side, a second side, a top, and a bottom, with the front face being wider than the back face and the first side and the second side being from the front face toward the back face.
摘要翻译: 模块化块系统包括第一块,第二块,第三块,第四块和盖石,第一块具有正面,背面,第一侧,第二侧,顶部和顶部 底部,其前表面比后表面宽,并且第一侧面从前表面向后表面倾斜,第二块具有正面,背面,第一面,第二面,顶部, 和底部,其前表面比后表面宽,并且第一和第二侧面从前表面向后表面倾斜,第三块具有前表面,后表面,第一侧,第二侧 顶部和底部,其前表面比后表面宽,并且第一侧面从前表面向后表面倾斜,并且第四块具有前表面,后表面,第一侧面, 第二面,顶部和底部,前表面比背面宽,第一面和第二面bei 从前面朝向背面。
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公开(公告)号:US08580254B2
公开(公告)日:2013-11-12
申请号:US12665373
申请日:2008-06-19
申请人: Paul Adam , Elinborg Ostermann
发明人: Paul Adam , Elinborg Ostermann
IPC分类号: A61K39/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
摘要翻译: 抗体分子,特别是与人IGF-1结合并与IGF-2交叉反应的完全人类抗体,使得IGF-1和IGF-2与IGF-1受体的结合被阻止,并且IGF-1受体介导的信号传导 被抑制。 抗体不结合胰岛素,因此不影响胰岛素与胰岛素受体结合介导的促有丝分裂特性。 抗体可用于治疗过度增生性疾病,特别是癌症。
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公开(公告)号:USD620135S1
公开(公告)日:2010-07-20
申请号:US29316487
申请日:2009-10-03
申请人: Paul Adam
设计人: Paul Adam
CPC分类号: E04C1/395 , E04B2002/0245 , E04B2002/026 , E04B2002/0263
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公开(公告)号:US20060233610A1
公开(公告)日:2006-10-19
申请号:US11104837
申请日:2005-04-13
申请人: Paul Adam
发明人: Paul Adam
IPC分类号: E01C5/00
CPC分类号: E01C5/06 , E01C2201/06
摘要: An interlocking paver stone system comprises a first paver stone having a generally oval configuration and a second paver stone having a generally star configuration having a first point, a second point, a third point, a fourth point, a first curved side between the first point and the second point, a second curved side between the second point and the third point, a third curved side between the third point and the fourth point, and a fourth curved side between the fourth point and the first point.
摘要翻译: 一种互锁摊铺机石系统,包括具有大致椭圆形构造的第一摊铺机石头和具有通常具有第一点,第二点,第三点,第四点,第一点 第二点,第二点和第三点之间的第二弯曲侧,第三点与第四点之间的第三弯曲侧,第四点与第一点之间的第四弯曲侧。
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公开(公告)号:US20140308383A1
公开(公告)日:2014-10-16
申请号:US14318048
申请日:2014-06-27
申请人: Paul Adam
发明人: Paul Adam
CPC分类号: B28B3/083 , A01G9/28 , B28B3/06 , B28B7/0097 , B28B7/24
摘要: A mold system for forming a multilevel block is disclosed which comprises a multilevel mold box insert for forming a multilevel block, a mold box frame adapted for receiving therein the multilevel mold box insert, a multilevel plunger assembly, and a press head plate adapted for receiving thereon the multilevel plunger assembly.
摘要翻译: 公开了一种用于形成多级块的模具系统,其包括用于形成多级块的多级模具盒插入件,适于在其中容纳多级模具盒插入件的多个模具箱框架,多级柱塞组件和适于接收 在其上的多级柱塞组件。
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