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公开(公告)号：US20090192072A1
公开(公告)日：2009-07-30
申请号：US12275885
申请日：2008-11-21
申请人： Renuka Pillutla , Renee Brissette , Arthur J. Blume , Lauge Schaffer , Jacob Brandt , Neil I. Goldstein , Jane Spetzler , Soren Ostergaard , Per Hertz Hansen
发明人： Renuka Pillutla , Renee Brissette , Arthur J. Blume , Lauge Schaffer , Jacob Brandt , Neil I. Goldstein , Jane Spetzler , Soren Ostergaard , Per Hertz Hansen
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂也可以作为治疗剂开发。
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公开(公告)号：US20070265189A1
公开(公告)日：2007-11-15
申请号：US11775642
申请日：2007-07-10
申请人： Renuka Pillutla , Renee Brissette , Arthur Blume , Lauge Schaffer , Jakob Brandt , Neil Goldstein , Jane Spetzler , Soren Ostergaard , Per Hansen
发明人： Renuka Pillutla , Renee Brissette , Arthur Blume , Lauge Schaffer , Jakob Brandt , Neil Goldstein , Jane Spetzler , Soren Ostergaard , Per Hansen
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂也可以作为治疗剂开发。
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公开(公告)号：US20110039779A1
公开(公告)日：2011-02-17
申请号：US12597482
申请日：2008-04-23
申请人： Soren Ostergaard , Renuta Pillutla , Paul Fletcher , Lauge Schaffer , Stenfeldt Mathiasen , Neil L. Goldstein , Jane Spetzler
发明人： Soren Ostergaard , Renuta Pillutla , Paul Fletcher , Lauge Schaffer , Stenfeldt Mathiasen , Neil L. Goldstein , Jane Spetzler
摘要： The present invention is drawn to new peptides and proteins that bind to human insulin-like growth factor-1 receptor (HIGF-IR), as well as nucleic acids encoding the same, vectors and cells comprising such nucleic acids, pharmaceutical compositions comprising such compounds, and methods of using any thereof, are provided.
摘要翻译： 本发明涉及结合人类胰岛素样生长因子-1受体（HIGF-IR）的新肽和蛋白质，以及编码其的核酸，包含该核酸的载体和细胞，包含这些化合物的药物组合物 ，及其使用方法。
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4.发明授权Glucose dependent release of insulin from glucose sensing insulin derivatives 有权从葡萄糖感测胰岛素衍生物中葡萄糖依赖性释放胰岛素公开(公告)号：US07316999B2
公开(公告)日：2008-01-08
申请号：US09870884
申请日：2001-05-31
申请人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
发明人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
CPC分类号： C07K14/62
摘要： Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.
摘要翻译： 具有内置葡萄糖传感器的胰岛素衍生物，其能够将来自贮库的胰岛素作为周围介质（例如组织）中的葡萄糖浓度的函数，使得从贮库中释放的胰岛素的速率随着葡萄糖浓度的增加而增加，并且 葡萄糖浓度降低。
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公开(公告)号：US20090099085A1
公开(公告)日：2009-04-16
申请号：US12282042
申请日：2007-03-15
申请人： Thomas Kruse Hansen , Lauge Schaffer , Jesper Lau
发明人： Thomas Kruse Hansen , Lauge Schaffer , Jesper Lau
IPC分类号： A61K38/16 , C07K14/575
CPC分类号： C07K14/4713 , A61K38/00 , C07K14/5759
摘要： The present invention relates to novel amylin derivatives having a protracted action profile, to pharmaceutical compositions comprising these derivatives and to the use of the derivatives for the treatment of diseases related to obesity, diabetes and other metabolic disorders.
摘要翻译： 本发明涉及具有延长作用特征的新型胰淀素衍生物，包含这些衍生物的药物组合物以及该衍生物用于治疗与肥胖症，糖尿病和其它代谢紊乱相关的疾病的用途。
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公开(公告)号：US20100298213A1
公开(公告)日：2010-11-25
申请号：US11660846
申请日：2005-08-19
申请人： Lauge Schaffer
发明人： Lauge Schaffer
IPC分类号： A61K38/17 , C07K14/705 , C12P21/06 , C07H21/04
摘要： The invention described herein provides novel pharmaceutically active molecules (including novel peptide derivatives and peptides) that bind to an insulin receptor; compositions comprising such molecules; methods of modulating insulin receptor activity comprising the delivery of such molecules and related insulin-binding molecules (e.g., in the context of treating and/or preventing insulin receptor-related diseases such as diabetes); nucleic acids encoding such peptides; vectors and host cells comprising such nucleic acids; and methods of producing such molecules and compositions.
摘要翻译： 本文描述的本发明提供了结合胰岛素受体的新的药物活性分子（包括新的肽衍生物和肽） 包含这种分子的组合物; 调节胰岛素受体活性的方法包括递送此类分子和相关的胰岛素结合分子（例如，在治疗和/或预防胰岛素受体相关疾病如糖尿病的情况下）; 编码这些肽的核酸; 包含这种核酸的载体和宿主细胞; 以及生产这种分子和组合物的方法。
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7.发明申请公开(公告)号：US20090197805A1
公开(公告)日：2009-08-06
申请号：US12089222
申请日：2006-10-03
申请人： Lauge Schaffer , Christian Lehn Brand , Ulla Ribel , Jeppe Sturis
发明人： Lauge Schaffer , Christian Lehn Brand , Ulla Ribel , Jeppe Sturis
CPC分类号： C07K14/62
摘要： Provided are new peptidic insulin receptor antagonists (PIRAs) and related compounds and compositions. Also provided are new uses of PIRAs and methods of obtaining PIRAs.
摘要翻译： 提供了新的肽胰岛素受体拮抗剂（PIRAs）和相关的化合物和组合物。 还提供了PIRA的新用途和获得PIRA的方法。
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8.发明申请Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof 审中-公开胰岛素受体结合肽与非胰岛素基因激活谱及其用途公开(公告)号：US20090197800A1
公开(公告)日：2009-08-06
申请号：US11718159
申请日：2005-10-14
CPC分类号： A61K38/16 , A61K38/28 , A61K2300/00
摘要： Methods for binding insulin receptors (and typically activating one or more function of an insulin receptor) by contacting insulin receptor-presenting cells, such as cells in a subject, with an effective amount of one or more insulin receptor binding peptides, where upregulation of one or more components of the insulin receptor-associated cholesterol synthesis pathway is not desired, are provided.
摘要翻译： 通过将受试者中的胰岛素受体呈递细胞（例如受试者中的细胞）与有效量的一种或多种胰岛素受体结合肽接触来结合胰岛素受体（并且通常激活胰岛素受体的一种或多种功能）的方法，其中上调一种 或更多的胰岛素受体相关胆固醇合成途径的组分是不期望的。
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公开(公告)号：US20080207507A1
公开(公告)日：2008-08-28
申请号：US11908836
申请日：2006-03-20
IPC分类号： C07K14/605 , A61K38/26 , A61P3/00 , A61P9/00 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
摘要： Protracted GLP-1 compounds and therapeutic uses thereof.
摘要翻译： 延长的GLP-1化合物及其治疗用途。
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公开(公告)号：US08603972B2
公开(公告)日：2013-12-10
申请号：US11908836
申请日：2006-03-20
IPC分类号： A61K38/26 , A61P3/10 , C07K14/605
CPC分类号： C07K14/605 , A61K38/00
摘要： The invention relates to protracted GLP-1 compounds and therapeutic uses thereof.
摘要翻译： 本发明涉及延长的GLP-1化合物及其治疗用途。
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