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公开(公告)号：US20070265189A1
公开(公告)日：2007-11-15
申请号：US11775642
申请日：2007-07-10
申请人： Renuka Pillutla , Renee Brissette , Arthur Blume , Lauge Schaffer , Jakob Brandt , Neil Goldstein , Jane Spetzler , Soren Ostergaard , Per Hansen
发明人： Renuka Pillutla , Renee Brissette , Arthur Blume , Lauge Schaffer , Jakob Brandt , Neil Goldstein , Jane Spetzler , Soren Ostergaard , Per Hansen
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂也可以作为治疗剂开发。
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公开(公告)号：US20090192072A1
公开(公告)日：2009-07-30
申请号：US12275885
申请日：2008-11-21
申请人： Renuka Pillutla , Renee Brissette , Arthur J. Blume , Lauge Schaffer , Jacob Brandt , Neil I. Goldstein , Jane Spetzler , Soren Ostergaard , Per Hertz Hansen
发明人： Renuka Pillutla , Renee Brissette , Arthur J. Blume , Lauge Schaffer , Jacob Brandt , Neil I. Goldstein , Jane Spetzler , Soren Ostergaard , Per Hertz Hansen
摘要： Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
摘要翻译： 公开了能够以激动剂或拮抗剂活性结合胰岛素和/或胰岛素样生长因子受体并由各种肽文库鉴定的肽序列。 本发明还鉴定存在于胰岛素和胰岛素样生长因子受体上并且选择性结合本发明的肽的至少两个不同的结合位点。 作为激动剂，本发明的某些肽可用于开发作为补充或代替内源肽激素的治疗剂。 拮抗剂也可以作为治疗剂开发。
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公开(公告)号：US20110039779A1
公开(公告)日：2011-02-17
申请号：US12597482
申请日：2008-04-23
申请人： Soren Ostergaard , Renuta Pillutla , Paul Fletcher , Lauge Schaffer , Stenfeldt Mathiasen , Neil L. Goldstein , Jane Spetzler
发明人： Soren Ostergaard , Renuta Pillutla , Paul Fletcher , Lauge Schaffer , Stenfeldt Mathiasen , Neil L. Goldstein , Jane Spetzler
摘要： The present invention is drawn to new peptides and proteins that bind to human insulin-like growth factor-1 receptor (HIGF-IR), as well as nucleic acids encoding the same, vectors and cells comprising such nucleic acids, pharmaceutical compositions comprising such compounds, and methods of using any thereof, are provided.
摘要翻译： 本发明涉及结合人类胰岛素样生长因子-1受体（HIGF-IR）的新肽和蛋白质，以及编码其的核酸，包含该核酸的载体和细胞，包含这些化合物的药物组合物 ，及其使用方法。
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4.发明授权Glucose dependent release of insulin from glucose sensing insulin derivatives 有权从葡萄糖感测胰岛素衍生物中葡萄糖依赖性释放胰岛素公开(公告)号：US07316999B2
公开(公告)日：2008-01-08
申请号：US09870884
申请日：2001-05-31
申请人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
发明人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
CPC分类号： C07K14/62
摘要： Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.
摘要翻译： 具有内置葡萄糖传感器的胰岛素衍生物，其能够将来自贮库的胰岛素作为周围介质（例如组织）中的葡萄糖浓度的函数，使得从贮库中释放的胰岛素的速率随着葡萄糖浓度的增加而增加，并且 葡萄糖浓度降低。
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公开(公告)号：US20050153888A1
公开(公告)日：2005-07-14
申请号：US10992287
申请日：2004-11-19
申请人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter Jensen , Flemming Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
发明人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter Jensen , Flemming Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , A61K38/17 , C07K14/47
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译： 本发明提供能够刺激呈递神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。 此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的方法。
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公开(公告)号：US06887844B1
公开(公告)日：2005-05-03
申请号：US09787443
申请日：1999-09-23
申请人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
发明人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , A61K38/04 , C07K7/00
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译： 本发明提供能够刺激来自呈递神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。 此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的药物组合物，药物和方法。
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7.发明授权Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer 有权用于R-state胰岛素六聚体的HisB10 Zn2 +位点的配体公开(公告)号：US07879893B2
公开(公告)日：2011-02-01
申请号：US10332541
申请日：2002-09-13
申请人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
发明人： Helle Birk Olsen , Niels C. Kaarsholm , Peter Madsen , Soren Ostergaard , Svend Ludvigsen , Palle Jakobsen , Anders Klarskov Petersen , Dorte Bjerre Steensgaard
IPC分类号： A61K31/41 , A61K31/40 , C07D257/00 , C07D209/82
CPC分类号： C07D257/04 , A61K31/4192 , A61K31/426 , C07D249/18 , C07D277/20 , C07D403/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
摘要翻译： 本发明涉及具有式A-B-C-D-X（III）的R状态胰岛素六聚体的HisB10 Zn 2+位点的新配体，其中：A是可逆结合胰岛素六聚体的HisB10 Zn 2+位点的化学基团; B是一个连接子; C是由0至5个中性氨基酸组成的片段; D是包含1至20个独立地选自氨基或胍基的带正电基团的片段; X为-OH，-NH 2或二氨基。 本发明还涉及包含这种配体的R状态胰岛素六聚体和包含这种R状态胰岛素六聚体的含水胰岛素制剂。
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公开(公告)号：US07402560B2
公开(公告)日：2008-07-22
申请号：US10992287
申请日：2004-11-19
申请人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
发明人： Lars Christian Ronn , Arne Holm , Marianne Olsen , Soren Ostergaard , Peter H. Jensen , Flemming M. Poulsen , Vladislav Soroka , Igor Ralets , Vladimir Berezin , Elisabeth Bock
IPC分类号： C07K14/435 , C07K14/705 , A61K38/00 , A61K38/04
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译： 本发明提供能够刺激呈递神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。 此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的方法。
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公开(公告)号：US20060069013A1
公开(公告)日：2006-03-30
申请号：US11227760
申请日：2005-09-12
申请人： Soren Ostergaard , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Soren Ostergaard , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/555
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/41 , A61K31/555
摘要： Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
摘要翻译： 公开了能够延长胰岛素制剂作用的R状态胰岛素六聚体的HisB10 Zn 2+ 2 +位点的新配体。
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公开(公告)号：US20050222041A1
公开(公告)日：2005-10-06
申请号：US10488517
申请日：2002-09-04
申请人： Lars Biilmann , Marianne Olsen , Elisabeth Bock , Vladimir Berezin , Flemming Poulsen , Arne Holm , Vladislav Soroka , Soren Ostergaard
发明人： Lars Biilmann , Marianne Olsen , Elisabeth Bock , Vladimir Berezin , Flemming Poulsen , Arne Holm , Vladislav Soroka , Soren Ostergaard
IPC分类号： C12N5/02 , A61K38/00 , A61L27/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P13/12 , A61P15/00 , A61P17/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07K4/00 , C07K7/00 , C07K7/06 , C07K14/00 , A61K38/08
CPC分类号： C07K7/06
摘要： The present invention concerns an NCAM (neural cell adhesion molecule) binding peptide capable of stimulating NCAM signalling and/or interfering with cell adhesion. The compound may be used for the treatment of diseases or conditions of the central and peripheral nervous system.
摘要翻译： 本发明涉及能够刺激NCAM信号传导和/或干扰细胞粘附的NCAM（神经细胞粘附分子）结合肽。 该化合物可用于治疗中枢和周围神经系统的疾病或病症。
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