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公开(公告)号：US07186761B2
公开(公告)日：2007-03-06
申请号：US10475374
申请日：2002-05-28
CPC分类号： A61L24/001 , A61L24/0089 , A61L27/16 , A61L27/44 , A61L27/50 , A61L2430/02 , C08L33/12
摘要： An acrylic radiopaque bone cement for orthopedic use comprises a solid phase composed of a mixture of at least one poly(methyl acrylate)-based polymer, one free-radical polymerization initiator and one or more substances opaque to X-rays, and a liquid phase substantially composed of a mixture of at least one monomer, one accelerator and one stabilizer. The radiopaque substances comprise metallic tungsten and tantalum particles, compounds or mixtures thereof, covered with a polymer coating compatible with said bone cement. The coating layer of the particles of radiopaque substances is an acrylic polymer based on poly(methyl methacrylate). The amount of radiopacifying element is between 1% and 20% by weight, relative to the solid phase, preferably between 2% and 5% by weight, relative to the solid phase. The solid phase may additionally comprise one or more pharmacologically active substances. The method for its preparation consists in preparing the radiopacifying material by coating the metal particles with a layer of a polymer which is compatible with the matrix and exhibits oxygen barrier properties such that said layer does not dissolve completely in the liquid phase so as to keep its oxygen barrier properties at least partly unchanged.
摘要翻译： 用于骨科用途的丙烯酸不透射线骨水泥包括由至少一种聚（甲基丙烯酸酯）基聚合物，一种自由基聚合引发剂和一种或多种对X射线不透明的物质的混合物组成的固相，以及液相 基本上由至少一种单体，一种促进剂和一种稳定剂的混合物组成。 不透射线的物质包括用与所述骨水泥相容的聚合物涂层覆盖的金属钨和钽颗粒，化合物或其混合物。 不透射线物质的颗粒的涂层是基于聚（甲基丙烯酸甲酯）的丙烯酸类聚合物。 相对于固相，放射性鉴定元素的量相对于固相为1重量％至20重量％，优选相对于固相为2重量％至5重量％。 固相可另外包含一种或多种药理活性物质。 其制备方法在于通过用与基质相容的聚合物层涂覆金属颗粒来制备放射性材料，并显示出阻氧性能，使得所述层不完全溶解在液相中，以保持其 氧阻隔性至少部分不变。
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2.发明申请Disposable articulated spacing device for surgical treatment of joints of the human body 审中-公开一次性关节间距装置，用于人体关节的外科治疗公开(公告)号：US20050119756A1
公开(公告)日：2005-06-02
申请号：US11029793
申请日：2005-01-05
CPC分类号： A61F2/38 , A61F2002/30672 , A61F2002/30677
摘要： A disposable articulated spacing device for the treatment of joints of the human body, particularly for temporarily replacing an explanted joint prosthesis, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to the other articulation end, both said members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis. The biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof. The articulated spacing device maintains a suitable space in the joint seat while allowing considerable articulated mobility, and re-establishes suitable conditions of implantation of a new permanent joint prosthesis.
摘要翻译： 一种用于治疗人体关节的一次性关节间隔装置，特别是用于临时替换外植关节假体的关节间隔装置包括至少一个第一构件，其能够被固定到第一铰接端，并且至少一个第二构件能够被固定到 另一个关节端，两个所述构件都是预先形成的，并且完全由生物相容性和多孔材料制成，适于加入药物和治疗产品。 预成形构件以铰接的方式往复耦合以保持合适的关节空间和至少部分关节，以进行进一步植入关节假体所需的时间。 生物相容性和多孔性材料选自金属，金属合金，有机金属，陶瓷，玻璃，塑料材料，骨水泥及其组合。 关节间隔装置在关节座中保持合适的空间，同时允许相当的铰接移动性，并且重新建立植入新的永久关节假体的合适条件。
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3.发明授权Disposable articulated spacing device for surgical treatment of joints of the human body 有权一次性关节间距装置，用于人体关节的外科治疗公开(公告)号：US07601176B2
公开(公告)日：2009-10-13
申请号：US10963123
申请日：2004-10-12
IPC分类号： A61F2/30
CPC分类号： A61F2/38 , A61F2002/30672 , A61F2002/30677
摘要： A disposable articulated spacing device for use as a temporary joint prosthesis includes a first member secured during an implantation procedure to a first articulation end and a separate and independent second member secured separately during the implantation procedure to the other articulation end, both members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis.
摘要翻译： 用作临时关节假体的一次性关节间隔装置包括在植入过程期间固定到第一关节端的第一构件和在植入过程期间单独固定到另一关节端的独立且独立的第二构件， 形成并完全由生物相容性和多孔材料制成，适合添加药物和治疗产品。 预成形构件以铰接的方式往复耦合以保持合适的关节空间和至少部分关节，以进行进一步植入关节假体所需的时间。
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公开(公告)号：US20050085918A1
公开(公告)日：2005-04-21
申请号：US10963123
申请日：2004-10-12
CPC分类号： A61F2/38 , A61F2002/30672 , A61F2002/30677
摘要： A disposable articulated spacing device for the treatment of joints of the human body, particularly for temporarily replacing an explanted joint prosthesis, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to the other articulation end, both said members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis. The biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof. The articulated spacing device maintains a suitable space in the joint seat while allowing considerable articulated mobility, and re-establishes suitable conditions of implantation of a new permanent joint prosthesis.
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