公开(公告)号：US20190322644A1

公开(公告)日：2019-10-24

申请号：US16341597

申请日：2017-10-11

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  Kenneth S. REHDER

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/14 ,  C07D233/90 ,  C07D401/04 ,  C07D249/10 ,  C07D401/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.

公开(公告)号：US20190315693A1

公开(公告)日：2019-10-17

申请号：US16448976

申请日：2019-06-21

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS

IPC: C07D231/14 ,  C07D405/12 ,  A61K45/06 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/422 ,  C07D403/12 ,  A61K31/496 ,  C07D413/12 ,  C07D407/12 ,  C07D403/06 ,  A61K31/454

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20190092809A1

公开(公告)日：2019-03-28

申请号：US16090726

申请日：2017-03-23

Applicant: Research Triangle Institute

Inventor： Scott RUNYON ,  Carla HASSLER ,  Craig SHINER ,  Sanju NARAYANAN

IPC: C07K5/02 ,  C07K5/065 ,  C07K11/00

Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.

公开(公告)号：US20220280483A1

公开(公告)日：2022-09-08

申请号：US17637659

申请日：2020-08-28

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Rangan MAITRA ,  Sanju NARAYANAN ,  Kenneth S. REHDER ,  Scott P. RUNYON

IPC: A61K31/415 ,  A61K31/496 ,  A61K31/4418 ,  A61P11/00

Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.

公开(公告)号：US20210070767A1

公开(公告)日：2021-03-11

申请号：US17082650

申请日：2020-10-28

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS ,  Kenneth S. REHDER ,  Srinivas OLEPU

IPC: C07D491/107 ,  C07D403/12 ,  C07D231/14 ,  C07D403/06 ,  C07D407/12 ,  C07D413/12 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20240174638A1

公开(公告)日：2024-05-30

申请号：US18278656

申请日：2022-02-15

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN

IPC: C07D401/14 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P9/00 ,  A61P11/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K31/427 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P9/00 ,  A61P11/00 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20180265518A1

公开(公告)日：2018-09-20

申请号：US15983519

申请日：2018-05-18

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS ,  Kenneth S. REHDER ,  Srinivas OLEPU

IPC: C07D491/107 ,  C07D403/04 ,  A61K31/5377 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D409/04 ,  C07D403/12 ,  C07D417/12 ,  C07D403/06 ,  C07D231/14 ,  C07D471/08 ,  C07D413/12 ,  C07D401/14 ,  C07D417/14 ,  A61K45/06 ,  C07D487/08 ,  C07D407/12 ,  A61K31/55 ,  A61K31/427 ,  A61K31/422 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/439 ,  C07D413/04

CPC classification number: C07D491/107 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.