公开(公告)号：US20180235900A1

公开(公告)日：2018-08-23

申请号：US15890171

申请日：2018-02-06

Applicant: Research Triangle Institute

Inventor： Stephanie Lynn Swarner ,  Leah Johnson ,  Robert F. Praino, JR. ,  Phillip Gregory Durham ,  Mark E. Kleiman ,  Ginger Denison Rothrock ,  Ariane van der Straten Ponthoz

IPC: A61K9/70 ,  A61K9/00 ,  A61K47/34 ,  A61K31/685 ,  C07K16/10 ,  B29C43/18 ,  B29C43/56 ,  B29C65/08 ,  B29C65/00

CPC classification number: A61K9/7007 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/4816 ,  A61K31/685 ,  A61K47/34 ,  B29C43/18 ,  B29C43/56 ,  B29C65/08 ,  B29C65/10 ,  B29C65/18 ,  B29C66/1122 ,  B29C66/24244 ,  B29C66/43 ,  B29C66/71 ,  B29C66/723 ,  B29C66/727 ,  B29C66/731 ,  B29C66/7352 ,  B29C66/73791 ,  B29C66/73921 ,  B29C66/8122 ,  B29C66/81431 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/849 ,  B29C66/919 ,  B29C66/949 ,  B29C2043/561 ,  B29K2067/00 ,  B29K2105/04 ,  B29K2105/253 ,  B29K2995/0097 ,  B29L2031/7148 ,  B29L2031/753 ,  C07K16/1045 ,  B29K2067/046 ,  B29K2827/18

Abstract: The medical devices of the present disclosure are filled reservoirs such as a cylinder comprised of a polymer film which contains a reservoir of active agent, plus excipient, in some cases, for disease prevention, treatment, and/or contraception. The polymer film is permeable to the active agent after subcutaneous implantation of the device into a body. The cylinder is comprised by the lamination of one or two polymer films which are ultrasonically welded to contain the drug material. The use of an ultrasonic welding process enables sealing of the polymer films to create the closed cylinder. The medical device is useful for long term disease prevention, such as prevention of HIV infection.

公开(公告)号：US11147763B2

公开(公告)日：2021-10-19

申请号：US15770722

申请日：2016-10-25

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Leah Marie Johnson ,  Stephanie Lynn Swarner ,  Ginger Denison Rothrock ,  Ariane Van Der Straten Ponthoz ,  Brian Rhys Stoner

IPC: A61K9/00 ,  A61F6/08 ,  A61M31/00

Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.

公开(公告)号：US20190070104A1

公开(公告)日：2019-03-07

申请号：US15770722

申请日：2016-10-25

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Leah Marie Johnson ,  Stephanie Lynn Swarner ,  Ginger Denison Rothrock ,  Ariane Van Der Straten Ponthoz ,  Brian Rhys Stoner

IPC: A61K9/00 ,  A61F6/08

Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.