-
公开(公告)号：US10220035B2
公开(公告)日：2019-03-05
申请号：US14750953
申请日：2015-06-25
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , A61K45/06 , C07D311/22 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
-
公开(公告)号：US09758474B2
公开(公告)日：2017-09-12
申请号：US14172707
申请日：2014-02-04
发明人： Meyyappan Muthuppalaniappan , Prashant K. Bhavar , Srikant Viswanadha , Swaroop K. Vakkalanka , Gayatri S. Merikapudi
IPC分类号： A01N37/18 , A01N43/40 , A01N43/32 , A01N43/38 , A61K31/50 , C07D211/72 , C07C233/00 , C12N5/00 , C07C235/56 , C07C233/65 , C07C233/66 , C07C233/75 , C07C309/59 , C07C317/32 , C07C323/42 , C07D209/14 , C07D213/75 , C07D213/81 , C07D231/56 , C07D241/24 , C07D307/79 , C07D317/58 , C07D319/18 , A61K31/167 , A61K31/185 , A61K31/196 , A61K31/343 , A61K31/357 , A61K31/405 , A61K31/416 , A61K31/44 , A61K45/06 , C07C235/84 , C07C309/52
CPC分类号： C07C235/56 , A61K31/167 , A61K31/185 , A61K31/196 , A61K31/343 , A61K31/357 , A61K31/405 , A61K31/416 , A61K31/44 , A61K45/06 , C07C233/65 , C07C233/66 , C07C233/75 , C07C235/84 , C07C309/52 , C07C309/59 , C07C317/32 , C07C323/42 , C07C2601/02 , C07C2601/08 , C07D209/14 , C07D213/75 , C07D213/81 , C07D231/56 , C07D241/24 , C07D307/79 , C07D317/58 , C07D319/18
摘要： The present invention provides dihydroorotate dehydrogenase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehydrogenase is known to show beneficial effect.
-
公开(公告)号：US20210401840A1
公开(公告)日：2021-12-30
申请号：US17301841
申请日：2021-04-15
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , A61K45/06 , C07D311/22 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
-
公开(公告)号：US11020399B2
公开(公告)日：2021-06-01
申请号：US16359419
申请日：2019-03-20
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： C07D311/22 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , A61K45/06 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides compounds of formula (10), formula (12), formula (14) and formula (15) wherein R, R1, R2, Cy1 and X are as described herein.
-
公开(公告)号：US20210032248A1
公开(公告)日：2021-02-04
申请号：US16865034
申请日：2020-05-01
IPC分类号： C07D473/34 , C07D473/04 , A61K31/52 , A61K45/06
摘要： The present invention relates to dual delta (δ) and gamma (γ) PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of Pi3K kinase mediated diseases or disorders with them.
-
公开(公告)号：US10322130B2
公开(公告)日：2019-06-18
申请号：US15677614
申请日：2017-08-15
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/352 , C07D311/22 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/185 , A61K31/5355 , A61K45/06 , C07D311/36 , C07D405/06 , C07D473/18 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides PI3K protein kinase modulators of formula wherein R, Cy1, R1, R2, L1 and Cy2 are as defined herein. The present invention also relates to methods of preparing compounds of formula (I) to pharmaceutical compositions containing them and to methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
-
公开(公告)号：US11466006B2
公开(公告)日：2022-10-11
申请号：US16865034
申请日：2020-05-01
IPC分类号： A61K31/52 , C07D473/34 , C07D473/04 , A61K45/06
摘要： The present invention relates to dual delta (δ) and gamma (γ) PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of Pi3K kinase mediated diseases or disorders with them.
-
![NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES](/abs-image/US/2021/12/02/US20210371416A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210371416A1
公开(公告)日：2021-12-02
申请号：US17303494
申请日：2021-05-30
发明人： Swaroop K. V. S. Vakkalanka , Dhanapalan Nagarathnam , Srikant Viswanadha , Meyyappan Muthuppalaniappan , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4709 , A61K45/06
摘要： The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.
-
![3,5-disubstituted-3H-imidazo[4,5-b]pyridine and 3,5-disubstituted-3H-[1,2,3]triazolo[4,5-B] pyridine compounds as modulators of c-Met protein kinases](/abs-image/US/2021/07/20/US11066402B2/abs.jpg.150x150.jpg)
公开(公告)号：US11066402B2
公开(公告)日：2021-07-20
申请号：US15705005
申请日：2017-09-14
发明人： Swaroop K. V. S. Vakkalanka , Dhanapalan Nagarathnam , Srikant Viswanadha , Meyyappan Muthuppalaniappan , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4709 , A61K45/06
摘要： The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.
-
公开(公告)号：US20190282581A1
公开(公告)日：2019-09-19
申请号：US16359419
申请日：2019-03-20
发明人： Dhanapalan Nagarathnam , Swaroop K. Vakkalanka , Meyyappan Muthuppalaniappan , Srikant Viswanadha , Govindarajulu Babu , Prashant K. Bhavar
IPC分类号： A61K31/519 , A61K45/06 , A61K31/5355 , A61K31/185 , A61K31/5377 , A61K31/52 , C07D487/04 , C07D473/40 , C07D473/34 , C07D473/18 , C07D405/06 , C07D311/36 , C07D311/22
摘要： The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.032 秒)
