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1.发明授权公开(公告)号：US06190303B1
公开(公告)日：2001-02-20
申请号：US09301442
申请日：1999-04-28
IPC分类号： A61N500
CPC分类号： G21F5/018 , A61N5/1002
摘要： A radiation shield assembly (30) for a radioactive stent (11) mounted onto a deployment portion (20) of a delivery apparatus (12) including a relatively thin, elongated tube member (69) having a wall (70) defining a receiving passage (72) formed and dimensioned for axial receipt of the stent mounted onto the deployment portion therein to substantially prevent direct contact with the stent (11). A removal structure (71) cooperating with the wall (70) of the tube member (69) for longitudinal severing thereof to enable selective removal of the tube member from the delivery apparatus (12) for deployment use thereof.
摘要翻译： 一种用于放射性支架（11）的辐射屏蔽组件（30），其安装在输送设备（12）的展开部分（20）上，该输送设备（12）包括相对薄的细长管构件（69），所述管构件具有限定接收通道 （72）的形状和尺寸用于轴支承安装在其上的展开部分上的支架，以基本上防止与支架（11）的直接接触。 与所述管构件（69）的壁（70）配合以用于其纵向切断的移除结构（71），以便能够从所述输送装置（12）中选择性地移除所述管构件以用于其部署。
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公开(公告)号：US6074381A
公开(公告)日：2000-06-13
申请号：US177668
申请日：1998-10-22
CPC分类号： A61F2/958 , A61F2002/9522 , Y10T29/53657
摘要： A stent loading apparatus for loading a deformable stent onto a deployment device. The stent loading apparatus includes an elastic member defining a passage therein formed for longitudinal receipt of the deformable stent in an uncrimped condition. A first member includes a first compression region; and a second member includes a second compression region positioned substantially adjacent the first compression region at a first position. At this first position, the elastic member and the deformable stent in the uncrimped condition may be received between the opposed first and second compression regions. The first compression region and the second compression region are further configured to provide rolling support and compression of the elastic member during relative movement between the first position and a second position for rolling radial compression of the deformable stent onto the deployment device.
摘要翻译： 一种用于将可变形支架装载到展开装置上的支架装载装置。 支架装载装置包括限定其中形成的通道的弹性构件，用于在未卷曲状态下纵向容纳可变形支架。 第一构件包括第一压缩区域; 并且第二构件包括在第一位置处基本上邻近所述第一压缩区域定位的第二压缩区域。 在该第一位置，可以在相对的第一和第二压缩区域之间容纳弹性构件和未松脱状态的可变形支架。 第一压缩区域和第二压缩区域进一步构造成在第一位置和第二位置之间的相对移动期间提供弹性构件的滚动支撑和压缩，用于将可变形支架的径向压缩滚动到展开装置上。
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公开(公告)号：US06309383B1
公开(公告)日：2001-10-30
申请号：US09488187
申请日：2000-01-20
IPC分类号： A61B1700
CPC分类号： B25B7/00 , A61F2/958 , A61F2002/9522 , A61F2210/0095 , B25B27/146
摘要： A stent crimping apparatus for crimping a deformable radioactive stent onto a deployment device which includes a first jaw member defining a shielded first compression surface, and an opposed, second jaw member defining a shielded second compression surface oriented opposite the first compression surface. The first and second compression surfaces are adapted to collectively form an elongated guide bore formed for axial receipt of the deformable stent and the deployment device therein. To protect against exposure to the radioactive stent, a shield assembly is provided defining an opening into a bore therein which is formed and dimensioned for longitudinal receipt of the deformable stent in an uncrimped condition. A shield assembly defines an opening into the bore, and cooperates with the first and second jaw members to substantially prevent radioactive particles emitted by the radioactive stent from passing out of the crimping apparatus. An operating mechanism is operatively coupled to the first and second jaw members for selective movement between a loading condition and a crimping condition. In the loading condition, the uncrimped stent and the deployment device may be inserted through the opening and into the bore. In the crimping condition, the deformable stent is radially compressed onto the deployment device between the first and second compression surfaces.
摘要翻译： 一种用于将可变形放射性支架卷曲到展开装置上的支架压接装置，所述展开装置包括限定屏蔽的第一压缩表面的第一钳口构件和限定与第一压缩表面相对定向的屏蔽的第二压缩表面的相对的第二钳口构件。 第一和第二压缩表面适于共同地形成用于轴向容纳可变形支架和其中的展开装置的细长导向孔。 为了防止暴露于放射性支架，设置屏蔽组件，其限定到其中的孔中的开口，其中形成并确定尺寸以使未变形状态的可变形支架的纵向接收。 屏蔽组件限定了孔内的开口，并且与第一和第二钳口构件配合，以基本上防止由放射性支架发射的放射性颗粒从压接装置传出。 操作机构可操作地联接到第一和第二钳口构件，用于在负载状态和压接状态之间的选择性运动。 在装载状态下，未卷曲的支架和展开装置可以通过开口插入孔中。 在卷曲状态下，可变形支架在第一和第二压缩表面之间径向压缩到展开装置上。
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公开(公告)号：US20100198128A1
公开(公告)日：2010-08-05
申请号：US12701333
申请日：2010-02-05
IPC分类号： A61F13/00
CPC分类号： A61F15/008
摘要： A flexible structural apparatus which may be used as a wound covering which extends above the wound such that the wound covering does not contact the wound and also protects the wound from contact. The apparatus provides a high degree of flexibility while retaining structural strength and resisting collapse, for example, so as to adequately protect the wound. Various embodiments include parallel beams and connections between beams that alternate in location along the beams to provide flexibility. Some embodiments may be used as springs and may have attachment features, such as holes, which may be located at the end beams, for example.
摘要翻译： 一种柔性结构设备，其可用作在伤口上方延伸的伤口覆盖物，使得伤口覆盖物不接触伤口并且还保护伤口免受接触。 该设备提供高度的灵活性，同时保持结构强度和抵抗塌陷，例如以充分保护伤口。 各种实施例包括平行光束和沿着光束位置交替的光束之间的连接，以提供灵活性。 一些实施例可以用作弹簧，并且可以具有例如可以位于端部梁处的附接特征，例如孔。
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公开(公告)号：US09078784B2
公开(公告)日：2015-07-14
申请号：US12701333
申请日：2010-02-05
CPC分类号： A61F15/008
摘要： A flexible structural apparatus which may be used as a wound covering which extends above the wound such that the wound covering does not contact the wound and also protects the wound from contact. The apparatus provides a high degree of flexibility while retaining structural strength and resisting collapse, for example, so as to adequately protect the wound. Various embodiments include parallel beams and connections between beams that alternate in location along the beams to provide flexibility. Some embodiments may be used as springs and may have attachment features, such as holes, which may be located at the end beams, for example.
摘要翻译： 一种柔性结构设备，其可用作在伤口上方延伸的伤口覆盖物，使得伤口覆盖物不接触伤口并且还保护伤口免受接触。 该设备提供高度的灵活性，同时保持结构强度和抵抗塌陷，例如以充分保护伤口。 各种实施例包括平行光束和沿着光束位置交替的光束之间的连接，以提供灵活性。 一些实施例可以用作弹簧，并且可以具有例如可以位于端部梁处的附接特征，例如孔。
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公开(公告)号：US08936558B2
公开(公告)日：2015-01-20
申请号：US11831925
申请日：2007-07-31
申请人： Stephen C. Jacobsen , Clark C. Davis , Clay W. Northrop , Ted W. Layman , Kevin T. Olson , Edward J. Snyder , D. Kent Backman , Todd H. Turnlund
发明人： Stephen C. Jacobsen , Clark C. Davis , Clay W. Northrop , Ted W. Layman , Kevin T. Olson , Edward J. Snyder , D. Kent Backman , Todd H. Turnlund
CPC分类号： A61M25/09 , A61M25/0013 , A61M25/01 , A61M25/09016
摘要： Medical devices for navigation through anatomy, including guidewires, which may have a core wire, a slotted tubular member, or both. Embodiments may have coils, including non-circular cross-section edge-wound marker coils, extended coil tips, and soldered or glued mesial joint coils. Core wires may have a step, ridge, or taper at the joints to the tubular member, and may be flattened at the distal tip. Radiopaque material may be located inside the tubular member, and the distal tip may be heat treated to make it shapeable. Additional tubular members or coils may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members may be chamfered or tapered continuously or incrementally. Slots may be arranged in groups, such as groups of three, and may be equal in depth or unequal in depth to provide a steerable or compressible tip.
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公开(公告)号：US09808595B2
公开(公告)日：2017-11-07
申请号：US11835207
申请日：2007-08-07
CPC分类号： A61M25/0013 , A61M25/0045 , A61M25/0051 , A61M25/0054 , A61M25/0138 , A61M2025/0006 , A61M2025/006
摘要： Medical devices and methods for making and using the same. An example medical device may include a tubular member and a liner disposed within the tubular member. The tubular member may have a plurality of slots formed therein. A space may be defined between the tubular member and the liner. One or more bonding members may be disposed in the space.
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8.发明授权Radioactive intraluminal endovascular prothesis and method for the treatment of aneurysms 失效放射性管腔内血管假体和治疗动脉瘤的方法公开(公告)号：US06554758B2
公开(公告)日：2003-04-29
申请号：US09755735
申请日：2001-01-05
申请人： Todd H. Turnlund , William L. Sweet
发明人： Todd H. Turnlund , William L. Sweet
IPC分类号： A61N500
CPC分类号： A61N5/1002 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B17/12181 , A61B17/12186 , A61F2/88 , A61F2/91 , A61F2250/0067
摘要： A method for increasing the rate of thrombus formation and/or proliferative cell growth of a selected region (21) of cellular tissue (22) including the step of endovascularly irradiating the selected region (21) with radiation, having a dose range of endovascular radiation of about 1 Gy to about 600 Gy at a low dose rate of about 1 cGy/hr to about 320 cGy/hr, to increase thrombus formation and/or cell proliferation of the affected selected region (21). Preferably, the delivery means includes a deformable endovascular prosthesis (25) adapted for secured positioning adjacent to the selected region (21) of cellular tissue (22), and a radioactive source. This source cooperates with the deformable endovascular device (25) in a manner endovascularly irradiating the selected region with radiation, having the above-indicated dose range and low dose rate of endovascular radiation to increase thrombus formation and/or cell proliferation of the affected selected region (21).
摘要翻译： 一种用于增加细胞组织（22）的选定区域（21）的血栓形成和/或增殖细胞生长速率的方法，包括用辐射血管内照射所选区域（21）的步骤，所述辐射具有剂量范围的血管内辐射 约1Gy至约600Gy，以约1ccy / hr的低剂量率至约320cGy / hr，以增加受影响的选择区域的血栓形成和/或细胞增殖（21）。 优选地，输送装置包括可变形的血管内假体（25），其适于邻近细胞组织（22）的选定区域（21）附近的固定定位和放射源。 该源与可变形的血管内装置（25）以与血管内照射所选区域的方式以具有上述剂量范围和低剂量率的血管内辐射以增加受影响的选择区域的血栓形成和/或细胞增殖的辐射协同 （21）。
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公开(公告)号：US5700286A
公开(公告)日：1997-12-23
申请号：US701405
申请日：1996-08-22
CPC分类号： A61F2/82 , A61F2/07 , A61F2/92 , A61F2/915 , A61F2002/075 , A61F2220/005 , A61F2250/0067
摘要： The drug loaded stent includes an expandable stent structural member, and a planar sheet of polymeric material attached to the outside of the expandable stent structural member. The polymeric material is preferably bioabsorbable, and loaded or coated with a therapeutic agent or drug to reduce or prevent restenosis in the vessel being treated. The polymer material can be attached to the metal stent at one or more points, and wrapped in a coil around the stent in an unexpanded state, to uncoil and expand in diameter to substantially match the expanded diameter of the metal stent; or can be wrapped tightly around the stent structural member and attached to itself, to stretch radially when the stent structural member is expanded. In another currently preferred embodiment, a combination of a stent structural member and a polymeric film wrapping can be provided with a coating of lubricious material. The lubricious material can be polyethylene oxide, polyethylene glycol, polyethylene acetate, polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylamide, hydrophilic soft segment urethanes, some natural gums, polyanhydrides or other similar hydrophilic polymers, and combinations thereof. The layer of lubricious material protects the stent from the guide or the body lumen in which the stent is inserted by providing a low friction surface over the stents.
摘要翻译： 药物负载支架包括可扩张的支架结构构件和附接到可扩张支架结构构件的外侧的聚合物材料的平面片。 聚合物材料优选是生物可吸收的，并且加载或涂覆有治疗剂或药物以减少或预防待治疗血管中的再狭窄。 聚合物材料可以以一个或多个点附着到金属支架上，并且以未膨胀的状态包裹在支架周围的线圈中，以直径展开和膨胀以与金属支架的扩张直径基本匹配; 或者可以紧紧地包裹在支架结构构件上并且附接到其自身，以在支架结构构件膨胀时径向拉伸。 在另一个目前优选的实施方案中，支架结构构件和聚合物膜包裹物的组合可以提供有润滑材料的涂层。 润滑材料可以是聚环氧乙烷，聚乙二醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙烯醇，聚丙烯酰胺，亲水性软链段聚氨酯，一些天然树胶，聚酐或其它类似的亲水聚合物，及其组合。 光滑材料层通过在支架上提供低摩擦表面来保护支架免于插入支架的引导件或体腔。
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10.发明授权公开(公告)号：US08932235B2
公开(公告)日：2015-01-13
申请号：US11831931
申请日：2007-07-31
申请人： Stephen C. Jacobsen , Clark C. Davis , Clay W. Northrop , Ted W. Layman , Kevin T. Olson , Edward J. Snyder , D. Kent Backman , Todd H. Turnlund
发明人： Stephen C. Jacobsen , Clark C. Davis , Clay W. Northrop , Ted W. Layman , Kevin T. Olson , Edward J. Snyder , D. Kent Backman , Todd H. Turnlund
CPC分类号： A61M25/09 , A61M25/0013 , A61M25/01 , A61M25/09016
摘要： Medical devices for navigation through anatomy, including guidewires, which may have a core wire, a slotted tubular member, or both. Embodiments may have coils, including non-circular cross-section edge-wound marker coils, extended coil tips, and soldered or glued mesial joint coils. Core wires may have a step, ridge, or taper at the joints to the tubular member, and may be flattened at the distal tip. Radiopaque material may be located inside the tubular member, and the distal tip may be heat treated to make it shapeable. Additional tubular members or coils may be used concentrically or in line and may enhance flexibility, provide radiopacity, reduce friction, or reduce material or manufacturing cost. Tubular members may be chamfered or tapered continuously or incrementally. Slots may be arranged in groups, such as groups of three, and may be equal in depth or unequal in depth to provide a steerable or compressible tip.
摘要翻译： 用于通过解剖学导航的医疗装置，包括可以具有芯线的导线，开槽的管状构件或两者。 实施例可以具有线圈，包括非圆形横截面边缘卷绕标记线圈，延伸的线圈尖端以及焊接或胶合的中间接合线圈。 芯线可以在与管状构件的接合处具有台阶，脊或锥形，并且可以在远侧末端处变平。 不透射线材料可以位于管状构件内部，并且远侧末端可以被热处理以使其成形。 附加的管状构件或线圈可以同心地或一致地使用，并且可以增强柔性，提供不透射线性，减少摩擦，或减少材料或制造成本。 管状构件可以被连续地或递增地倒角或锥形。 槽可以以三组排成一组，并且可以在深度上相等或者深度不等，以提供可转向或可压缩的尖端。
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