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公开(公告)号：US6028214A
公开(公告)日：2000-02-22
申请号：US063834
申请日：1998-04-21
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07D263/22 , C07D263/26 , G11B20/14 , G11B27/30 , C07C69/66
CPC分类号： A61K31/197 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C69/34 , C07C69/675 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027 , C07C2101/14
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.
摘要翻译： 下式化合物其中R 1是具有1至6个碳原子的直链或支链烷基，苯基或具有3至6个碳原子的环烷基; R2是氢或甲基; 并且R 3是氢，甲基或羧基; 其用于治疗癫痫发作。 还公开了制备该化合物的方法。 进一步公开了在合成化合物期间制备的中间体。
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公开(公告)号：US06359169B1
公开(公告)日：2002-03-19
申请号：US08732065
申请日：1996-10-16
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： C07C6934
CPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C2601/14 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027
摘要： A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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公开(公告)号：US5710304A
公开(公告)日：1998-01-20
申请号：US733102
申请日：1996-10-16
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07D263/22 , C07D263/26 , G11B20/14 , G11B27/30 , C07C303/00
CPC分类号： A61K31/197 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C69/34 , C07C69/675 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027 , C07C2101/14
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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公开(公告)号：US06525096B1
公开(公告)日：2003-02-25
申请号：US09244313
申请日：1999-02-04
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31195
CPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C2601/14 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027
摘要： A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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公开(公告)号：US06255345B1
公开(公告)日：2001-07-03
申请号：US09244676
申请日：1999-02-04
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31195
CPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C2601/14 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027
摘要： A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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公开(公告)号：US5847151A
公开(公告)日：1998-12-08
申请号：US891470
申请日：1997-07-10
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07D263/22 , C07D263/26 , G11B20/14 , G11B27/30 , C07D263/04
CPC分类号： A61K31/197 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C69/34 , C07C69/675 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027 , C07C2101/14
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
摘要翻译： 式Ⅰ化合物，其中R1是具有1至6个碳原子的直链或支链烷基，苯基或具有3至6个碳原子的环烷基; R2是氢或甲基; 并且R 3是氢，甲基或羧基; 其用于治疗癫痫发作。 公开了用于制备化合物的方法。 还公开了在合成化合物期间制备的中间体。
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公开(公告)号：US06342529B1
公开(公告)日：2002-01-29
申请号：US09243946
申请日：1999-02-04
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31195
CPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C2601/14 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027
摘要： A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
摘要翻译： 式R 1的化合物是具有1至6个碳原子的直链或支链烷基，苯基或具有3至6个碳原子的环烷基; R2是氢或甲基; 并且R 3是氢，甲基或羧基; 其用于治疗癫痫发作。 公开了用于制备化合物的方法。 还公开了在合成化合物期间制备的中间体。
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公开(公告)号：US06414024B1
公开(公告)日：2002-07-02
申请号：US09244700
申请日：1999-02-04
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31195
CPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C2601/14 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027
摘要： A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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公开(公告)号：US06117906A
公开(公告)日：2000-09-12
申请号：US244699
申请日：1999-02-04
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07D263/22 , C07D263/26 , G11B20/14 , G11B27/30 , A61K31/195
CPC分类号： A61K31/197 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C69/34 , C07C69/675 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027 , C07C2101/14
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
摘要翻译： 下式化合物其中R 1是具有1至6个碳原子的直链或支链烷基，苯基或具有3至6个碳原子的环烷基; R2是氢或甲基; 并且R 3是氢，甲基或羧基; 其用于治疗癫痫发作。 公开了用于制备化合物的方法。 还公开了在合成化合物期间制备的中间体。
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公开(公告)号：US5684189A
公开(公告)日：1997-11-04
申请号：US420576
申请日：1995-04-12
申请人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
发明人： Richard B. Silverman , Ryszard Andruszkiewicz , Po-Wai Yuen , Denis Martin Sobieray , Lloyd Charles Franklin , Mark Alan Schwindt
IPC分类号： A61K31/197 , C07C69/34 , C07C69/675 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07D263/22 , C07D263/26 , G11B20/14 , G11B27/30 , C07C205/00
CPC分类号： A61K31/197 , C07C229/08 , C07C229/24 , C07C229/28 , C07C229/34 , C07C247/12 , C07C309/73 , C07C69/34 , C07C69/675 , C07D263/22 , C07D263/26 , G11B20/1426 , G11B27/3027 , C07C2101/14
摘要： A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
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