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48 条记录 (耗时 0.033 秒)

    Cephalosporin antibiotics
    1.
    发明授权
    Cephalosporin antibiotics 失效
    头孢菌素类抗生素

    公开(公告)号：US5043334A

    公开(公告)日：1991-08-27

    申请号：US441612

    申请日：1989-11-27

    申请人： Richard Bell ,  Michael W. Foxton ,  Brian E. Looker

    发明人： Richard Bell ,  Michael W. Foxton ,  Brian E. Looker

    IPC分类号： A61K31/545 ,  A61P31/04 ,  C07D277/20 ,  C07D501/20 ,  C07D501/24

    CPC分类号： C07D277/587 ,  Y02P20/55

    摘要： Compounds of general formula (I) ##STR1## (where R.sup.1 is a carboxyl group, a group COO.sup..crclbar. or a blocked carboxyl group;R.sup.2 is an amino or protected amino group; andR is hydrogen or a group of the formula CH.sub.2 X, where X represents a halogen atom, a hydroxyl group, an acetoxy group; a group of the formula O.CO.NHR.sup.3, where R.sup.3 is hydrogen, a C.sub.1-4 alkyl group optionally substituted by 1 to 3 halogen atoms or an N-protecting group; a group of the formula OR.sup.4, where R.sup.4 is a C.sub.1-4 alkyl group optionally substituted by halogen or a C.sub.1-4 alkoxy group; or a pyridinium, 3-carbamoyl-pyridinium or 4-carbamoyl-pyridinium group;B is --S-- or --SO-- (.alpha.- or .beta.-); and the dotted line bridging the 2-, 3- and 4- positions indicates that the compound is a ceph-2-em or ceph-3-em compound) and salts thereof, the compounds of formula (I) being associated with an anion when X represents a pyridinium, 3-carbamoylpyridinium group or a 4-carbamoylpyridinium group and R.sup.1 is other than COO.sup..crclbar.) are disclosed.Processes for their preparation and pharmaceutical compositions containing them are also disclosed.

    摘要翻译： 通式（I）的化合物（Ⅰ）（其中R1是羧基，COO（ - ）或封端羧基; R2是氨基或被保护的氨基; R是氢或一个 式CH 2 X，其中X表示卤素原子，羟基，乙酰氧基;式O.CO.NHR 3的基团，其中R 3是氢，任选被1至3个卤素原子取代的C 1-4烷基或 N-保护基;式OR4的基团，其中R4是任选被卤素或C 1-4烷氧基取代的C 1-4烷基;或吡啶鎓，3-氨基甲酰基 - 吡啶鎓或4-氨基甲酰基 - 吡啶鎓基 ; B是-S-或-SO-（α-或β-）;桥接2-，3-和4-位的虚线表示该化合物是ceph-2-em或ceph-3-em 化合物）及其盐，当X表示吡啶鎓，3-氨基甲酰基吡啶鎓基或4-氨基甲酰基吡啶基且R 1不同于COO（ - ）时，式（I）的化合物与阴离子缔合。 还公开了其制备方法和含有它们的药物组合物。

    3-(Optionally substituted-but-1-en-3-ynyl) cephalosporins
    2.
    发明授权
    3-(Optionally substituted-but-1-en-3-ynyl) cephalosporins 失效
    3-（任选取代的，1-en-3-炔基）头孢菌素

    公开(公告)号：US4666899A

    公开(公告)日：1987-05-19

    申请号：US732094

    申请日：1985-05-09

    申请人： Richard Bell ,  Paul D. Hallam ,  Michael W. Foxton

    发明人： Richard Bell ,  Paul D. Hallam ,  Michael W. Foxton

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/20 ,  C07D501/06 ,  C07D501/14 ,  C07D501/16 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/60 ,  C07F7/18

    CPC分类号： C07D277/587 ,  C07F7/1852

    摘要： Compounds of general formula I ##STR1## (wherein R represents NH.sub.2 -- or an acylated or silylated amino group;R.sup.2 represents a hydrogen, halogen, alkyl, aryl, carboxyl or lower alkoxycarbonyl group;R.sup.3 is hydrogen or a carboxyl blocking group;B is >Sor>S.fwdarw.O (.alpha.- or .beta.-); and the dotted line represents .DELTA..sup.2 or .DELTA..sup.3 unsaturation) and salts, solvates and esters thereof are described.Compounds where R.sup.3 is hydrogen, the dotted line represents .DELTA..sup.3 unsaturation and R is a group of formula ##STR2## (where R.sup.a is an optionally substituted heterocyclic aryl group having one or more hetero atoms selected from S, N and O in the ring, R.sup.b is an optionally substituted aryl group, R.sup.c is hydrogen, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, R.sup.d is as defined for R.sup.a or is an optionally substituted group and X is amino, hydroxyl, acylated hydroxyl, carboxyl or esterified carboxyl)and especially the compounds in which B is >S, have valuable antibiotic activities.Compounds in which the --CH.dbd.CH--C.tbd.C--R.sup.2 group is in the trans configuration have been found to have good oral absorption.The remaining compounds of formula (I) are valuable as intermediates in processes for the preparation of the above active antibiotics, which processes are also described.

    摘要翻译： 通式I的化合物（I）（其中R表示NH 2 - 或酰化或甲硅烷基化的氨基; R 2表示氢，卤素，烷基，芳基，羧基或低级烷氧基羰基; R 3是氢或羧基封端基 ; B是> Sor> S-> O（α-或β-）;虚线代表DELTA 2或DELTA 3不饱和键）及其盐，溶剂合物和酯。 其中R 3为氢的化合物，虚线表示DELTA 3不饱和度，R为式R a R 2 CONH（R a）的基团，其中R a为具有一个或多个选自S，N和O的杂原子的任选取代的杂环芳基 在环中，R b是任选取代的芳基，R c是氢，酰基，烷基，烯基，炔基，环烷基，环烷基烷基，芳基或芳烷基，Rd如对Ra定义或是任选取代的基团，X是氨基，羟基 ，酰化羟基，羧基或酯化羧基），特别是其中B> S的化合物具有有价值的抗生素活性。 已经发现其中-CH = CH-C 3 D C-R 2基团处于反式构型的化合物具有良好的口服吸收。 剩余的式（I）化合物在制备上述活性抗生素的方法中作为中间体是有价值的，该方法也被描述。

    Utilities pod for caravans
    3.
    发明授权
    Utilities pod for caravans 有权

    公开(公告)号：US09649995B2

    公开(公告)日：2017-05-16

    申请号：US13501332

    申请日：2010-10-13

    申请人： David Smyth ,  Patrick Hurst ,  Richard Bell ,  Richard Bovill

    发明人： David Smyth ,  Patrick Hurst ,  Richard Bell ,  Richard Bovill

    IPC分类号： B60R7/04 ,  B60R15/00

    CPC分类号： B60R15/00

    摘要： A utilities pod (10) for a vehicle, especially a caravan. The pod is removably mounted underneath the cabin structure and contains utilities apparatus such as a water heater, space heater (62), battery and water tank (60). The pod is connected to the cabin of the vehicle by an interface unit having multiple ports (18) by which said respective utility services are provided to the cabin. The interface unit is configured for installation in the floor of said cabin such that the ports are exposed to the interior of the cabin structure.

    Aerodynamic brake system
    5.
    发明授权
    Aerodynamic brake system 有权
    气动制动系统

    公开(公告)号：US08079609B2

    公开(公告)日：2011-12-20

    申请号：US12695960

    申请日：2010-01-28

    申请人： Richard Bell ,  Timothy Saul Lane ,  William Duehring ,  James Michael Felt ,  Jeffrey A. Soucek ,  David Tyson Buckenberger

    发明人： Richard Bell ,  Timothy Saul Lane ,  William Duehring ,  James Michael Felt ,  Jeffrey A. Soucek ,  David Tyson Buckenberger

    IPC分类号： B62K19/30

    CPC分类号： B62K19/38 ,  B62K21/02

    摘要： An aerodynamic braking system is disclosed herein. In particular, the brake arms may define an aerodynamic leading portion or edge and may be integrated into the legs of the front fork. Also, the brake arms may be disposed behind the bottom bracket shell to take the rear brake out of the air flow path and reduce aerodynamic drag. The rear brake arms are tapered so that the brake arms remain sufficient stiff to provide sufficient brake response times. The rear brake arms may be matched to recesses formed on an underside of chain stays.

    摘要翻译： 本文公开了一种空气动力学制动系统。 特别地，制动臂可以限定空气动力学引导部分或边缘，并且可以集成到前叉的腿部中。 此外，制动臂可以设置在底部支架壳体的后面，以将后部制动器从空气流动路径中取出并减小气动阻力。 后制动臂是锥形的，使得制动臂保持足够的刚度以提供足够的制动响应时间。 后制动臂可以与形成在链条撑杆下侧的凹槽相匹配。

    System for maintaining balance data
    8.
    发明申请
    System for maintaining balance data 审中-公开
    维持平衡数据的系统

    公开(公告)号：US20050187870A1

    公开(公告)日：2005-08-25

    申请号：US11064289

    申请日：2005-02-22

    申请人： Michael Grear ,  Teresa Harrington ,  Richard Bell

    发明人： Michael Grear ,  Teresa Harrington ,  Richard Bell

    IPC分类号： G06F17/60

    CPC分类号： G06Q10/10 ,  G06Q10/06 ,  G06Q20/10 ,  G06Q40/02 ,  G06Q40/12

    摘要： According to one embodiment of the invention, an architecture is provided for a data processing system that processes data for a service provider itself or a client of a service provider as in the case of a third party processor. The elements of the architecture can be managed separately. For example, the architecture can be organized around eight subject areas, such as account, party, communication point, presentation instrument, rules, balances, transactions, and product. Relationships between each of the subject areas as well as between sub-types of each subject area can be established to provide flexibility in the management of the data.

    摘要翻译： 根据本发明的一个实施例，提供了一种用于数据处理系统的架构，其处理服务提供商本身或服务提供商的客户端的数据，如在第三方处理器的情况下。 架构的元素可以单独管理。 例如，架构可以组织在八个主题领域，如帐户，派对，通信点，演示文稿，规则，余额，交易和产品。 可以建立每个主题领域之间以及每个主题区域的子类型之间的关系，以提供对数据管理的灵活性。

    Privacy booth
    10.
    发明申请
    Privacy booth 有权
    隐私展位

    公开(公告)号：US20070227078A1

    公开(公告)日：2007-10-04

    申请号：US11716913

    申请日：2007-03-12

    申请人： Patrick McGonagle ,  Richard Bell

    发明人： Patrick McGonagle ,  Richard Bell

    IPC分类号： A47F10/00 ,  E04H1/00

    CPC分类号： E04H1/1255

    摘要： The present invention concerns a privacy booth comprising at least two partition members having first and second terminal ends; and at least two linking members having first and second opposed ends, each second terminal end of the partition member and each first opposed end of the linking members forming a first pivotable coupling, each first terminal end of the partition members and each second opposed end of the linking member forming a second pivotable coupling, the privacy booth being operable between a deployed state, in which adjacent partition members are spaced-apart to define a respective compartment therebetween, and a storage state in which adjacent partition members are substantially parallel with one another, and preferably flat packed against one another.

    摘要翻译： 本发明涉及一种隐私保护室，包括具有第一和第二终端的至少两个分隔构件; 以及具有第一和第二相对端的至少两个连接构件，所述分隔构件的每个第二末端和所述连接构件的每个第一相对端形成第一可枢转联接，所述分隔构件的每个第一末端和每个第二相对端 所述连接构件形成第二可枢转联接件，所述保护室可在展开状态之间操作，所述展开状态中相邻的分隔构件间隔开以在其间限定相应的隔室，以及相邻分隔构件彼此基本平行的存储状态 ，并且优选地彼此平坦包装。