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    Functionalized oligosaccharides
    3.
    发明申请
    Functionalized oligosaccharides 有权
    官能化寡糖

    公开(公告)号：US20120309680A1

    公开(公告)日：2012-12-06

    申请号：US13468849

    申请日：2012-05-10

    申请人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    发明人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    IPC分类号： C08B37/02 ,  A61K38/18

    CPC分类号： A61K38/28 ,  A61K47/61 ,  C08B37/0021

    摘要： The invention relates to an oligodextran, chosen from dextrans whose average degree of polymerization is less than 10, modified by at least one substituent of general formula I: —R1-[[AA]-[R2]n]m  formula I It also relates to a pharmaceutical composition characterized in that it comprises an oligosaccharide according to the invention and an active ingredient is chosen from the group consisting of proteins, glycoproteins, peptides and non-peptide therapeutic molecules.

    摘要翻译： 本发明涉及一种选自平均聚合度小于10的葡聚糖的寡葡聚糖，其通过通式I至少一个取代基修饰：-R1 - [[AA] - [R2] n] m式I还涉及 涉及一种药物组合物，其特征在于其包含根据本发明的寡糖，活性成分选自蛋白质，糖蛋白，肽和非肽治疗分子。

    Polysaccharides comprising carboxyl functional groups substituted via esterification by a hydrophobic alcohol
    5.
    发明申请
    Polysaccharides comprising carboxyl functional groups substituted via esterification by a hydrophobic alcohol 审中-公开
    包含通过疏水性醇酯化而被羧基官能团取代的多糖

    公开(公告)号：US20110112039A1

    公开(公告)日：2011-05-12

    申请号：US12943425

    申请日：2010-11-10

    申请人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    发明人： Richard CHARVET ,  Remi SOULA ,  Olivier SOULA

    IPC分类号： C08B37/00 ,  C08B37/02 ,  A61K38/02 ,  A61K38/14

    CPC分类号： C08B37/00 ,  A61K31/00 ,  C08B37/0018 ,  C08B37/0021

    摘要： Polysaccharide including carboxyl functional groups. The polysaccharide being chosen from the group of anionic synthetic polysaccharides including 1,6 bonds obtained from neutral polysaccharides of which at least one of a carboxyl functional groups is esterified by a hydrophobic alcohol (-Ah) (residue of a hydrophobic alcohol). The hydrophobic alcohol (Ah) being grafted or bonded to the anionic polysaccharide by a function F (ester function), which results from coupling between the carboxylate function of the anionic polysaccharide and hydroxyl function of the hydrophobic alcohol. Carboxyl functions of anionic polysaccharide, which are not substituted, are in the form of carboxylate of a cation. The polysaccharide including carboxyl functional groups are amphiphilic at neutral pH.It also relates to its use for the preparation of pharmaceutical compositions and the pharmaceutical compositions comprising a polysaccharide and at least one active principle.

    摘要翻译： 多糖包括羧基官能团。 所述多糖选自阴离子合成多糖，包括由中性多糖获得的1,6键，其中至少一个羧基官能团被疏水性醇（-Ah）（疏水性醇的残基）酯化。 由阴离子多糖的羧酸盐官能团与疏水性醇的羟基官能团的结合产生的功能F（酯官能团）将疏水性醇（Ah）接枝或键合到阴离子多糖上。 未被取代的阴离子多糖的羧基官能团是阳离子的羧酸盐形式。 包含羧基官能团的多糖在中性pH下是两亲性的。 它还涉及其用于制备药物组合物和包含多糖和至少一种活性成分的药物组合物的用途。