公开(公告)号：US20060167220A1

公开(公告)日：2006-07-27

申请号：US11321035

申请日：2005-12-28

申请人： Richard Dauer ,  Christina Evanson ,  Paul Friedrich ,  Hafez Hafezzadeh ,  Ramakrishna Nalitham ,  Stephen Schneider ,  Mark Schwindt ,  Roger Snyder ,  Joseph White ,  Gregory Withers

发明人： Richard Dauer ,  Christina Evanson ,  Paul Friedrich ,  Hafez Hafezzadeh ,  Ramakrishna Nalitham ,  Stephen Schneider ,  Mark Schwindt ,  Roger Snyder ,  Joseph White ,  Gregory Withers

IPC分类号： C07K14/00

CPC分类号： C07K14/005 ,  C07K1/145 ,  C07K1/303 ,  C07K14/605 ,  C12N2740/16122

摘要： The formation of inactive, insoluble forms of peptide can be minimized or, alternatively, inactive, insoluble forms of peptide compounds, if present, can be converted into more physiologically active, soluble forms by dissolving peptide samples in aqueous base and then acidifying the aqueous mixture to precipitate the peptide in the presence of at least one of a salt and a co-solvent. Preferably, both a salt and co-solvent are present. By carrying out the precipitation relatively rapidly (at least in a first stage of acidifying in which the pH of the alkaline medium is reduced to a pH in the range of 6 to 7.5, after which acidification to a final desired pH, e.g., 3 to 6, can occur more slowly) at relatively low temperature, the dissolution characteristics of the resultant precipitated peptide are even further improved. The process is robust, consistent, and suitable for commercial scale manufacture of peptides.

摘要翻译： 通过将肽样品溶解在碱性水溶液中，然后使含水混合物酸化，可以使肽的无活性，不溶性形式形成，或者如果存在的话，可以通过将肽化合物的不溶形式（如果存在的话）转化为更具生理活性的可溶形式， 以在盐和共溶剂中的至少一种的存在下沉淀肽。 优选地，存在盐和共溶剂。 通过相对快速地进行沉淀（至少在第一阶段的酸化中，将碱性介质的pH降低至6至7.5范围内的pH，然后酸化至最终所需的pH，例如3至 6，可以更慢地发生），在所得沉淀肽的溶解特性进一步提高。 该方法稳健，一致，适用于商业规模生产肽。

公开(公告)号：US20070179278A1

公开(公告)日：2007-08-02

申请号：US11701910

申请日：2007-02-02

申请人： John Dwyer ,  Brian Bray ,  Stephen Schneider ,  Huyi Zhang ,  Nicolai Tvermoes ,  Barbara Johnston ,  Paul Friedrich

发明人： John Dwyer ,  Brian Bray ,  Stephen Schneider ,  Huyi Zhang ,  Nicolai Tvermoes ,  Barbara Johnston ,  Paul Friedrich

IPC分类号： C07K14/00 ,  C07K16/00 ,  C07K1/00 ,  A61K38/00 ,  C07K17/00 ,  C07K2/00 ,  C07K7/00 ,  C07K5/00 ,  C07K4/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/16022 ,  C12N2740/16122 ,  G01N2333/16 ,  G01N2800/26

摘要： Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

摘要翻译： 本发明提供了具有SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：11，SEQ ID NO：12，SEQ ID NO：13，SEQ ID NO： 14或SEQ ID NO：15; 并且提供了包含HIV融合抑制剂肽和药学上可接受的载体和大分子载体中的一种或多种的药物组合物，以及由这些组合物提供的用途和治疗方法。

公开(公告)号：US20120236370A1

公开(公告)日：2012-09-20

申请号：US13436637

申请日：2012-03-30

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/24 ,  H04N1/04

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A records management system and method that permits paper records to be tagged, stored and retrieved according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Output from the system may include summary excerpts whereby summaries for data contained in select pages of each document in a project are associated with at least dates, page numbers, and providers for the data.

摘要翻译： 一种记录管理系统和方法，可以根据用户标准对纸质记录进行标记，存储和检索。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 来自系统的输出可以包括摘要摘录，其中包含在项目中的每个文档的选择页面中的数据的摘要与数据的至少日期，页码和提供者相关联。

公开(公告)号：US11163925B1

公开(公告)日：2021-11-02

申请号：US16396738

申请日：2019-04-28

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F30/20 ,  G05B17/02 ,  H02J3/00 ,  G06F119/06

摘要： A simulator models an energy and power system. The simulator allows a user to manipulate digital representations of nodes, which represent one or more components of power and energy assets. The simulator also allows a user to manipulate digital representations of edges, which connect the nodes, to form a power and energy network. A plurality of object classes correspond to the nodes and edges. The object classes comprise class inheritance structures so that constraints of a parent class are retained by one or more child classes. The interface on the simulator allows a user to model a power and energy system by allowing the user to connect the nodes with edges to construct a power and energy system, wherein the object classes for the nodes, when executed by the simulator, implement one or more dynamical models to model the power and energy assets.

公开(公告)号：US08600904B1

公开(公告)日：2013-12-03

申请号：US13561609

申请日：2012-07-30

申请人： Stephen Schneider ,  David DePaolo ,  Christopher Floyd

发明人： Stephen Schneider ,  David DePaolo ,  Christopher Floyd

IPC分类号： G06Q30/00

CPC分类号： G06Q30/00

摘要： A document delivery system for electronic and physical documents with proof of service. The system may receive uploaded electronic documents for delivery to one or more electronic and/or physical endpoints. After the electronic documents have been received, the delivery system determines whether the received electronic documents should be delivered electronically or physically, based on recipient data in the delivery system. If physical documents are to be delivered, the system may intelligently decide whether to aggregate some documents into a multi-document package. The system provides for delivery by commercial carrier, postal service, and/or electronic delivery. Optional services available to the sender include, but are not limited to, certified mail, proof of service, and email confirmation.

摘要翻译： 电子和物理文件的文件传送系统，具有服务证明。 系统可以接收上传的电子文档以递送到一个或多个电子和/或物理端点。 在接收到电子文档之后，传送系统基于传送系统中的接收者数据来确定接收到的电子文档是以电子还是物理方式传送的。 如果要交付物理文件，系统可以智能地决定是否将一些文档合并成多文档包。 该系统提供商业运营商，邮政服务和/或电子交付。 发件人提供的可选服务包括但不限于：认证邮件，服务证明和电子邮件确认。

公开(公告)号：US20090177618A1

公开(公告)日：2009-07-09

申请号：US12008139

申请日：2008-01-09

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/30

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A record tagging, storage and filtering system and method that permits paper records to be tagged, stored and filtered according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Because the pages may be sorted according to user criteria, the user may shuffle through pages from various different documents, thus allowing them to quickly retrieve the records they need and perform such actions as trend-spotting.

摘要翻译： 记录标记，存储和过滤系统和方法，允许根据用户标准对纸张记录进行标记，存储和过滤。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目进行分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 由于页面可以根据用户标准进行排序，所以用户可以从各种不同的文档中翻页，从而允许他们快速地检索他们需要的记录，并执行诸如趋势检测的动作。

公开(公告)号：US07882091B2

公开(公告)日：2011-02-01

申请号：US12008139

申请日：2008-01-09

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/30

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A record tagging, storage and filtering system and method that permits paper records to be tagged, stored and filtered according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Because the pages may be sorted according to user criteria, the user may shuffle through pages from various different documents, thus allowing them to quickly retrieve the records they need and perform such actions as trend-spotting.

摘要翻译： 记录标记，存储和过滤系统和方法，允许根据用户标准对纸张记录进行标记，存储和过滤。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 由于页面可以根据用户标准进行排序，所以用户可以从各种不同的文档中翻页，从而允许他们快速地检索他们需要的记录，并执行诸如趋势检测的动作。

公开(公告)号：US08301611B2

公开(公告)日：2012-10-30

申请号：US12853927

申请日：2010-08-10

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/00

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A records management system and method that permits paper records to be tagged, stored and retrieved according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Because the pages may be sorted according to user criteria, the user may shuffle through pages from various different documents, thus allowing them to quickly retrieve the records they need and perform such actions as trend-spotting.

摘要翻译： 一种记录管理系统和方法，可以根据用户标准对纸质记录进行标记，存储和检索。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 由于页面可以根据用户标准进行排序，用户可以从各种不同的文档中翻页，从而允许他们快速地检索他们需要的记录，并执行诸如趋势检测的动作。

公开(公告)号：US20110164820A1

公开(公告)日：2011-07-07

申请号：US12853927

申请日：2010-08-10

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/30 ,  G06F17/00 ,  G06K9/00

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A records management system and method that permits paper records to be tagged, stored and retrieved according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Because the pages may be sorted according to user criteria, the user may shuffle through pages from various different documents, thus allowing them to quickly retrieve the records they need and perform such actions as trend-spotting.

摘要翻译： 一种记录管理系统和方法，可以根据用户标准对纸质记录进行标记，存储和检索。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 由于页面可以根据用户标准进行排序，所以用户可以从各种不同的文档中翻页，从而允许他们快速地检索他们需要的记录，并执行诸如趋势检测的动作。

公开(公告)号：US08458155B2

公开(公告)日：2013-06-04

申请号：US13436637

申请日：2012-03-30

申请人： Stephen Schneider

发明人： Stephen Schneider

IPC分类号： G06F17/00

CPC分类号： G06F17/243 ,  G06F17/217 ,  G06F17/30011 ,  G06F17/30014 ,  G06F17/30067 ,  G06F17/30115 ,  G06F17/30286

摘要： A records management system and method that permits paper records to be tagged, stored and retrieved according to user criteria. The system includes a scanning module, a central server, one or more user workstations and an optical character recognition server. After scanning, the records may then be serialized and categorized by project, and then supplemented automatically by the system with a hypertext data file. The system provides for the manual input of additional hypertext data and merger of the hypertext data file with other records in the project. The end user may then search and/or filter records according to information contained in the hypertext data file. Output from the system may include summary excerpts whereby summaries for data contained in select pages of each document in a project are associated with at least dates, page numbers, and providers for the data.

摘要翻译： 一种记录管理系统和方法，可以根据用户标准对纸质记录进行标记，存储和检索。 该系统包括扫描模块，中央服务器，一个或多个用户工作站和光学字符识别服务器。 扫描后，记录可以按序列化，并按项目分类，然后由系统自动补充超文本数据文件。 该系统提供手动输入其他超文本数据，并将超文本数据文件与项目中的其他记录合并。 然后，最终用户可以根据包含在超文本数据文件中的信息搜索和/或过滤记录。 来自系统的输出可以包括摘要摘录，其中包含在项目中的每个文档的选择页面中的数据的摘要与数据的至少日期，页码和提供者相关联。