公开(公告)号：US20060167220A1

公开(公告)日：2006-07-27

申请号：US11321035

申请日：2005-12-28

申请人： Richard Dauer ,  Christina Evanson ,  Paul Friedrich ,  Hafez Hafezzadeh ,  Ramakrishna Nalitham ,  Stephen Schneider ,  Mark Schwindt ,  Roger Snyder ,  Joseph White ,  Gregory Withers

发明人： Richard Dauer ,  Christina Evanson ,  Paul Friedrich ,  Hafez Hafezzadeh ,  Ramakrishna Nalitham ,  Stephen Schneider ,  Mark Schwindt ,  Roger Snyder ,  Joseph White ,  Gregory Withers

IPC分类号： C07K14/00

CPC分类号： C07K14/005 ,  C07K1/145 ,  C07K1/303 ,  C07K14/605 ,  C12N2740/16122

摘要： The formation of inactive, insoluble forms of peptide can be minimized or, alternatively, inactive, insoluble forms of peptide compounds, if present, can be converted into more physiologically active, soluble forms by dissolving peptide samples in aqueous base and then acidifying the aqueous mixture to precipitate the peptide in the presence of at least one of a salt and a co-solvent. Preferably, both a salt and co-solvent are present. By carrying out the precipitation relatively rapidly (at least in a first stage of acidifying in which the pH of the alkaline medium is reduced to a pH in the range of 6 to 7.5, after which acidification to a final desired pH, e.g., 3 to 6, can occur more slowly) at relatively low temperature, the dissolution characteristics of the resultant precipitated peptide are even further improved. The process is robust, consistent, and suitable for commercial scale manufacture of peptides.

摘要翻译： 通过将肽样品溶解在碱性水溶液中，然后使含水混合物酸化，可以使肽的无活性，不溶性形式形成，或者如果存在的话，可以通过将肽化合物的不溶形式（如果存在的话）转化为更具生理活性的可溶形式， 以在盐和共溶剂中的至少一种的存在下沉淀肽。 优选地，存在盐和共溶剂。 通过相对快速地进行沉淀（至少在第一阶段的酸化中，将碱性介质的pH降低至6至7.5范围内的pH，然后酸化至最终所需的pH，例如3至 6，可以更慢地发生），在所得沉淀肽的溶解特性进一步提高。 该方法稳健，一致，适用于商业规模生产肽。

公开(公告)号：US20070179278A1

公开(公告)日：2007-08-02

申请号：US11701910

申请日：2007-02-02

申请人： John Dwyer ,  Brian Bray ,  Stephen Schneider ,  Huyi Zhang ,  Nicolai Tvermoes ,  Barbara Johnston ,  Paul Friedrich

发明人： John Dwyer ,  Brian Bray ,  Stephen Schneider ,  Huyi Zhang ,  Nicolai Tvermoes ,  Barbara Johnston ,  Paul Friedrich

IPC分类号： C07K14/00 ,  C07K16/00 ,  C07K1/00 ,  A61K38/00 ,  C07K17/00 ,  C07K2/00 ,  C07K7/00 ,  C07K5/00 ,  C07K4/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/16022 ,  C12N2740/16122 ,  G01N2333/16 ,  G01N2800/26

摘要： Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.

摘要翻译： 本发明提供了具有SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：11，SEQ ID NO：12，SEQ ID NO：13，SEQ ID NO： 14或SEQ ID NO：15; 并且提供了包含HIV融合抑制剂肽和药学上可接受的载体和大分子载体中的一种或多种的药物组合物，以及由这些组合物提供的用途和治疗方法。

公开(公告)号：US4577505A

公开(公告)日：1986-03-25

申请号：US634990

申请日：1984-07-27

申请人： Hans-Achim Jestrich ,  Paul Friedrich

发明人： Hans-Achim Jestrich ,  Paul Friedrich

IPC分类号： G01N29/04 ,  G01N29/24

CPC分类号： G01N29/2487 ,  G01N29/2437 ,  G01N2291/0421 ,  G01N2291/0422 ,  G01N2291/2693

摘要： A special angle beam probe for ultrasonic testing includes at least one ultrasonic vibrator fastened in a beam probe housing on a wedge-shaped support body which may be formed of Plexiglass, using damping means. The ultrasonic beam of the vibrator strikes the surface of the test piece at an incidence angle other than 0.degree., as measured from a perpendicular at the surface of the test piece at the point where the beam strikes. The ultrasonic beam furthermore strikes the test piece surface at an oblique angle between 0.degree. and 360.degree. subtended between a principal beam probe axis and the beam, as seen in the direction perpendicular to the beam probe from above. The novelty of the invention is that the special angle beam probe includes a multiplicity of prefabricated beam probe subassemblies. The ultrasonic vibrator of each subassembly is fastened with a predetermined incidence angle within a first beam probe housing. A second beam probe housing contains the test head subassembly and the test head subassembly can be fastened at least at one predetermined oblique angle within the second housing for forming the overall special angle beam probe. In this way a multiplicity of beam probe subassemblies with the same insonification angle form special angle beam probes with different, predetermined oblique angles, by assembling the subassemblies in second test head housings in different oblique angle relationships.

摘要翻译： 用于超声波测试的特殊角度束探头包括至少一个超声波振动器，该超声波振动器使用阻尼装置固定在可由有机玻璃形成的楔形支撑体上的束探针外壳中。 振动器的超声波束以不同于0度的入射角撞击试验片的表面，从在试样的表面处的垂直方向测量。 超声波束在主光束探针轴与光束之间以0°和360°之间的倾斜角度进一步撞击测试片表面，如从垂直于光束探头的方向看的那样。 本发明的新颖之处在于，特殊角度束探头包括多个预制的束探针组件。 每个子组件的超声波振动器以预定的入射角度紧固在第一光束探测器壳体内。 第二光束探测器壳体包含测试头子组件，并且测试头子组件可以在第二壳体内至少固定一个预定的倾斜角度，以形成整个特殊角度的光束探头。 以这种方式，通过以不同的倾斜角度关系将子组件组装在第二测试头壳体中，具有相同声子角的多个光束探测子组件形成具有不同的预定倾斜角度的特殊角度光束探头。

公开(公告)号：US06302429B1

公开(公告)日：2001-10-16

申请号：US09442058

申请日：1999-11-16

申请人： Paul Friedrich

发明人： Paul Friedrich

IPC分类号： B62M114

CPC分类号： A61G5/023 ,  A61G5/00 ,  A61G5/025 ,  A61G5/026 ,  A61G5/027 ,  A61G5/08 ,  A61G5/0825 ,  A61G5/10 ,  A61G5/1051 ,  A61G5/128

摘要： A simple, durable, lightweight, economical wheelchair is disclosed that offers full convertibility from rigid frame to folding and vice versa, without sacrificing advantages of either design. In addition, it allows conversion to sports, companion, pediatric, front wheel drive, etc. as well as customizing to suit the end user's needs.

摘要翻译： 公开了一种简单，耐用，重量轻，经济的轮椅，其提供了从刚性框架到折叠的完全可转换性，反之亦然，而不牺牲任何一种设计的优点。 此外，它允许转换为运动，伴侣，儿科，前轮驱动等，以及定制以适应最终用户的需求。

公开(公告)号：US06270105B1

公开(公告)日：2001-08-07

申请号：US09442059

申请日：1999-11-16

申请人： Paul Friedrich

发明人： Paul Friedrich

IPC分类号： B62K100

CPC分类号： A61G5/023 ,  A61G5/00 ,  A61G5/025 ,  A61G5/026 ,  A61G5/027 ,  A61G5/0825 ,  A61G5/10 ,  A61G5/1051 ,  A61G5/1054 ,  A61G5/1075 ,  A61G5/12 ,  A61G5/128

摘要： A method of constructing a wheelchair that is durable, lightweight, economical and fully adaptable to any end user's requirements, such as sizing, convertibility, environment and lifestyle, and the resulting wheelchair, is disclosed, made possible by the utilization of specially designed weld-free connector fittings with any desirable or available tubular materials.

摘要翻译： 公开了通过使用专门设计的焊接工艺来构建耐用，轻便，经济且完全适应任何最终用户要求的轮椅的方法，例如尺寸，可转换性，环境和生活方式以及所得到的轮椅， 具有任何所需或可用的管状材料的自由连接器配件。

公开(公告)号：US5467164A

公开(公告)日：1995-11-14

申请号：US080908

申请日：1993-06-21

申请人： Thomas R. Wells ,  Leo DaPrato ,  Paul Friedrich ,  Kenneth Hendrickson ,  Merv LaRue ,  John Overman ,  Duane Patuszynski ,  Dale Plum ,  Al Rabin ,  Stuart Schwalb ,  Dan Solomon ,  Larry Turner ,  David Briggs ,  Herb Hausmann

发明人： Thomas R. Wells ,  Leo DaPrato ,  Paul Friedrich ,  Kenneth Hendrickson ,  Merv LaRue ,  John Overman ,  Duane Patuszynski ,  Dale Plum ,  Al Rabin ,  Stuart Schwalb ,  Dan Solomon ,  Larry Turner ,  David Briggs ,  Herb Hausmann

IPC分类号： G03B27/50 ,  G03B27/52 ,  G03B27/32

CPC分类号： G03B27/521 ,  G03B27/50

摘要： A document processing system for performing multiple document processing tasks while the documents travel in a straight line document path is provided. The document processing system may include a transport system for transporting the documents in a straight line path, a sensing system for sensing the presence of the document, an optical system for projecting the image of the document, a camera module for receiving the projected image and storing it onto film, a film marking system for placing blips on the film adjacent the document image, a film numbering system for placing alphanumeric characters on the film adjacent the document image, an endorsing system for placing a printed endorsement on one side of the document, an electro-optical scanning system for scanning the image of the document processing the signal into a bit mapped image or for use with external communications devices, scanning for bar code symbology, and imprinting characters on the documents.A machine having a transport system to serially move documents in a straight line path and having one or more of the systems is provided and can be serially linked to another like machine so that the exit of a first machine is the inlet to the second machine.

摘要翻译： 提供了一种用于在文档以直线文档路径行进的同时执行多个文档处理任务的文档处理系统。 文件处理系统可以包括用于以直线路径传送文件的传送系统，用于感测文件的存在的感测系统，用于投影文档的图像的光学系统，用于接收投影图像的相机模块和 将其存储在电影上，用于将胶片放置在邻近文件图像的胶片上的胶片标记系统，用于在与文档图像相邻的胶片上放置字母数字字符的胶片编号系统，用于在文档的一面放置印刷背书的认可系统 用于将处理信号的文档的图像扫描成位映射图像或与外部通信设备一起使用的电光扫描系统，扫描条形码符号和在文档上打印字符。 具有传送系统的机器被设置成沿直线路径串行地移动并且具有一个或多个系统的传送系统，并且可以连续地连接到另一个类似的机器，使得第一机器的出口是第二机器的入口。

公开(公告)号：US06227752B1

公开(公告)日：2001-05-08

申请号：US09442057

申请日：1999-11-16

申请人： Paul Friedrich

发明人： Paul Friedrich

IPC分类号： F16B704

CPC分类号： F16B7/0453 ,  F16B2012/406 ,  F16B2200/403 ,  Y10T403/3933 ,  Y10T403/4611

摘要： A failsafe weld-free method of joining tubular elements provides for connecting a first tubular element to a second tubular element. The assembly includes an insert, with screw threads, inside of the first tube, a connector fitting for mounting to the insert within the first tube by a screw, a second tube is secured to the connector fitting with a fastener through a transverse hole through both the second tube and the connector fitting. When the connector fitting is assembled to the first tubular section and the connecting screw is tightened, a structurally rigid connection is achieved. The second tubular section is positioned over the stepped outside diameter of the connector fitting, aligning the transverse holes. A fastener is installed through the transverse hole. The fastener that secures the connector fitting to the second tubular section is positioned to not allow the screw fastening the connector fitting to the first tubular section to disengage or loosen. The resulting joint is structurally rigid in all planes without a visible fastener on the first tubular section with no distortion to the tubing due to bolt torque.

摘要翻译： 连接管状元件的无故障无焊接方法提供了将第一管状元件连接到第二管状元件。 该组件包括具有螺纹的插入件，在第一管的内部，用于通过螺钉安装到第一管内的插入件的连接器配件，第二管通过穿过两个孔的横向孔通过紧固件固定到连接器配件上 第二管和连接器配件。 当连接器配件组装到第一管状部分并且连接螺钉被紧固时，实现了结构上刚性的连接。 第二管状部分位于连接器配件的阶梯状外径上方，对准横向孔。 紧固件通过横向孔安装。 将连接器配件固定到第二管状部分的紧固件被定位成不允许将连接器配件的螺钉紧固到第一管状部分以脱离或松开。 所得到的接头在所有平面上是结构上刚性的，在第一管状部分上没有可见的紧固件，由于螺栓扭矩而没有对管道的变形。

公开(公告)号：US5253888A

公开(公告)日：1993-10-19

申请号：US35691

申请日：1993-04-02

申请人： Paul Friedrich

发明人： Paul Friedrich

IPC分类号： A61G5/00 ,  A61G5/12 ,  A61G5/02

CPC分类号： A61G5/08 ,  A61G5/00 ,  A61G5/125 ,  A61G5/128

摘要： A wheelchair assembly which can be quickly and inexpensively assembled and disassembled is described which is formed of tubular members which are secured only with clamping members to produce a rigid frame wheelchair. No welds are utilized, the clamps being formed of molded composite material, such as a carbon fiber-filled polyamide. Each clamp is formed of complimentary shells formed with semi-cylindrical regions dimensioned to receive, between two mating complimentary members, cross tubes to be secured in pressure fit relationship.

摘要翻译： 描述了可以快速且廉价地组装和拆卸的轮椅组件，其由仅由夹紧构件固定以制造刚性框架轮椅的管状构件形成。 没有使用焊缝，夹具由模制复合材料形成，例如填充碳纤维的聚酰胺。 每个夹具由形成有半圆柱形区域的互补壳形成，其尺寸被设计成在两个配合互补构件之间接收以压配合关系固定的横管。