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公开(公告)号：US5672767A
公开(公告)日：1997-09-30
申请号：US675842
申请日：1996-07-05
IPC分类号： C08G65/00 , C08G65/323 , C07C43/11 , C08G73/24
CPC分类号： C08G65/3236 , C08G65/007
摘要： A process for the preparation of a perfluoropolyether having a general formula: ##STR1## as defined hereinbefore, which process includes the direct fluorination with elemental fluorine of a polyether having a general formula: ##STR2## as defined hereinbefore, wherein the fluorination is carried out in the presence of a solvent which is an ether having at least one substituent R.sub.F, wherein R.sub.F is a fluorinated hydrocarbon group. The said solvent ether is preferably a fluorinated volatile ether. The said solvent ether preferably has at least two groups R.sub.F which may be the same or different groups. Each group R.sub.F preferably has from two to four carbon atoms and at least two fluorine atoms. The said solvent ether may be an alicyclic ether having from 3 to 5 carbon atoms in its alicyclic ring. The intermediate polyether of formula (2) may be prepared by a process in which an appropriate straight-chained or cyclic polyether is reacted with an appropriate fluoroalkene in the presence of a sensitising medium and ultra-violet radiation is applied to energise the medium and promote multiple fluorination.
摘要翻译： 一种制备具有上述通式的全氟聚醚的方法：该方法包括用上述通式如下定义的具有以下通式的聚醚的元素氟直接氟化： 其中氟化是在具有至少一个取代基RF的醚的溶剂的存在下进行的，其中RF是氟化烃基。 所述溶剂醚优选为氟化挥发性醚。 所述溶剂醚优选具有至少两个可以相同或不同基团的基团。 每组RF优选具有2至4个碳原子和至少2个氟原子。 所述溶剂醚可以是其脂环中具有3至5个碳原子的脂环醚。 式（2）的中间体聚醚可以通过一种方法制备，其中适当的直链或环状聚醚在敏化介质存在下与合适的氟代烯烃反应，并且使用紫外辐射来激发介质并促进 多次氟化。
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公开(公告)号：US5859255A
公开(公告)日：1999-01-12
申请号：US849942
申请日：1997-06-20
IPC分类号： C07D239/30 , C07D213/61 , C07D215/18 , C07D221/12 , C07D239/72 , C07D241/44 , C07D211/72 , C07D211/84
CPC分类号： C07D241/44 , C07D213/61 , C07D215/18 , C07D221/12
摘要： A method of fluorinating a heterocyclic organic compound comprises the step of reacting a heterocyclic compound with elemental fluorine in the presence of another halogen. The reaction may be conducted in the presence of a base.
摘要翻译： PCT No.PCT / GB95 / 02950 Sec。 371日期：1997年6月20日 102（e）日期1997年6月20日PCT 1995年12月18日PCT PCT。 公开号WO96 / 19456 PCT 日期1996年6月27日一种氟化杂环有机化合物的方法包括在另一卤素存在下使杂环化合物与元素氟反应的步骤。 反应可以在碱的存在下进行。
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公开(公告)号：US06441232B1
公开(公告)日：2002-08-27
申请号：US09936593
申请日：2002-01-01
IPC分类号： C07C23106
CPC分类号： C07B43/06 , C07C231/06 , C07C2601/14 , C07C2602/28 , C07C2602/42 , C07C2603/74 , C07C233/06
摘要： There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a solvent reaction medium comprising a nitrile compound and providing a Lewis acid whereby the carbon-hydrogen bond is replaced by a carbon-nitrogen bond. Advantageously, the reaction may be performed in one stage and/or in one vessel. Advantageously, the method may be carried out at or just below ambient or room temperature.
摘要翻译： 提供了通过碳 - 氮键选择性地置换有机化合物中未活化的饱和sp 3杂化碳原子上的碳 - 氢键的方法，该方法包括使化合物与氟化剂在包含腈的溶剂反应介质中反应 化合物并提供路易斯酸，由此碳 - 氢键被碳 - 氮键取代。 有利地，反应可以在一个阶段和/或一个容器中进行。 有利地，该方法可以在或低于环境温度或室温下进行。
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公开(公告)号：US06747178B1
公开(公告)日：2004-06-08
申请号：US09530231
申请日：2000-10-02
申请人： Paul Harston , Malcolm John Atherton , Robert G. Holmes , Richard Dickinson Chambers , Robert Spink
发明人： Paul Harston , Malcolm John Atherton , Robert G. Holmes , Richard Dickinson Chambers , Robert Spink
IPC分类号： C07C1700
CPC分类号： C07C381/00 , B01J19/0093 , B01J2219/00822 , B01J2219/00833 , B01J2219/00835 , B01J2219/00873 , B01J2219/00889 , B01J2219/0093 , C07B39/00 , C07C17/04 , C07C45/46 , C07C51/62 , C07C67/307 , C07C22/00 , C07C55/40 , C07C69/716
摘要： According to the present invention there is provided a method of carrying out a chemical reaction between at least two fluids, the method comprising providing respective flow paths for the at least two fluids, said flow paths communicating with each other in a region in which the at least two fluids may contact each other, and flowing the at least two fluids along said flow paths such that in said region the at least two fluids contact each other and a chemical reaction occurs between them, said region having a width perpendicular to the direction of flow in the range 10-10,000 micrometers. It has been found that using a so-called “microreactor”, that is a reactor having dimensions perpendicular to the flow direction of less than 10,000 micrometers, according to the present method, improved control over a fluid chemical reaction can be achieved, which can result in significant improvements in reaction product yield and/or purity, as well as other benefits. The present method has been found to be particularly beneficial for fluorination reactions.
摘要翻译： 根据本发明，提供了一种在至少两种流体之间进行化学反应的方法，所述方法包括为所述至少两种流体提供相应的流动路径，所述流动路径在其中在所述至少两个流体的区域中彼此连通 至少两种流体可以彼此接触，并且使所述至少两种流体沿着所述流动路径流动，使得在所述区域中，所述至少两种流体彼此接触并且在它们之间发生化学反应，所述区域具有垂直于 流量范围在10-10,000微米。 已经发现，根据本方法使用所谓的“微反应器”，即具有垂直于流动方向的尺寸小于10,000微米的反应器，可以实现对流体化学反应的改进的控制，其可以实现 导致反应产物产率和/或纯度的显着改善以及其它益处。 已经发现本方法对氟化反应特别有利。
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公开(公告)号：US07541008B2
公开(公告)日：2009-06-02
申请号：US10513546
申请日：2003-05-09
IPC分类号： B01J10/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00869 , B01J2219/00961 , B01J2219/00963 , B01L3/5027
摘要： A reactor for carrying out a reaction between at least two fluids comprises a reactor plate (20) with a plurality of grooves or through slots (22) in which the fluids mix and react and a separable overlying reservoir plate (2) for supplying the fluids to slots (22) from reservoirs (4, 6) via slots (10) a, (10) b, with a collecting conduit or reservoir (8) and slots (10) c for the product of the reaction. Reservoir plate (2) may lie between two reactor plates, or a single reactor plate (20) may lie between two reservoir plates. Third or further reservoirs may or may not be spaced from the second reservoir (6) depending on whether more than two fluids need to be present simultaneously, or whether a second reaction is required after the first two fluids have had time to react. Means may be provided for controlling the pressure in slots (22), the pressure differential (and flow rate) along slot (22), and/or the temperature in the reservoirs (4, 6) or slots (22). Multiple reactors may be coupled in parallel/series for scaling up or for performing plural or progressive reactions (such as perfluorination).
摘要翻译： 用于在至少两种流体之间进行反应的反应器包括具有多个槽的反应器板（20）或通过槽（22），流体混合和反应的反应器板（20）和用于供应流体的可分离的上部储存器板（2） 通过槽（10）a，（10）b与储存器（4,6）的槽（22）与收集管道或储存器（8）和用于反应产物的槽（10）c相连。 储层板（2）可以位于两个反应器板之间，或者单个反应器板（20）可以位于两个储存器板之间。 取决于是否需要同时存在多于两种的流体，或者在前两种流体有时间反应之后是否需要第二反应，第三或另外的储存器可以或可以不与第二储存器（6）间隔开。 可以提供用于控制槽（22）中的压力，沿着槽（22）的压力差（和流速）和/或储存器（4,6）或槽（22）中的温度的装置。 多个反应器可以并联/串联以进行放大或用于进行多个或逐步反应（例如全氟化）。
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公开(公告)号：US06300511B1
公开(公告)日：2001-10-09
申请号：US09463030
申请日：2000-03-27
IPC分类号： C07F902
CPC分类号： C07C315/04 , C07B39/00 , C07C67/307 , C07C201/12 , C07C231/12 , C07C253/30 , C07F9/4006 , C07C69/716 , C07C69/63 , C07C317/24 , C07C255/19 , C07C235/80 , C07C205/51
摘要： The present invention provides a method of substituting a carbonyl compound with fluorine at the &agr;-position, comprising reaching the carbonyl compound with a fluorinating present of a metal-containing catalyst. The reaction results in replacement of a hydrogen atom by fluorine. The catalyst, which is used in a catalytically effective amount, is preferably a transition metal. In one class of methods the catalyst is a transition metal compound. In another class of methods, the catalyst is an elemental metal, in which case the carbonyl compound has an activating group attached to the carbon atom which is substituted by fluorine.
摘要翻译： 本发明提供了在α-位置用氟取代羰基化合物的方法，包括用含金属的催化剂的氟化存在物到达羰基化合物。 该反应导致用氟代替氢原子。 以催化有效量使用的催化剂优选为过渡金属。 在一类方法中，催化剂是过渡金属化合物。 在另一类方法中，催化剂是元素金属，在这种情况下，羰基化合物具有与被氟取代的碳原子连接的活化基团。
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7.发明授权Phosphazene derivatives and use of same as stabilizers for oils and greases based on perfluoropolyethers 失效磷腈衍生物和基于全氟聚醚的油和油脂稳定剂的使用
公开(公告)号：US5705668A
公开(公告)日：1998-01-06
申请号：US739960
申请日：1996-10-30
IPC分类号： C07F9/535 , C07F9/6581 , C07F9/6593 , C08G79/02 , C10M169/00 , C10M169/04 , C10N20/02 , C10N30/06 , C10N30/10 , C10N50/10 , C07F9/659 , C07F9/24
CPC分类号： C08G79/025 , C07F9/65812 , C07F9/65815 , C10M169/00 , C10M169/04 , C10M2211/06 , C10M2213/00 , C10M2213/02 , C10M2213/023 , C10M2213/04 , C10M2213/043 , C10M2213/06 , C10M2213/0606 , C10M2213/062 , C10M2213/0623 , C10M2223/02 , C10M2223/049 , C10M2223/08 , C10N2250/10
摘要： New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropolyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.
摘要翻译： 完全被芳基和全氟聚醚链取代的新的磷腈衍生物被用作基于全氟聚醚的油和油脂的稳定剂。 当这些衍生物在氧化气氛中和在金属例如铝，钛，钒及其合金或钢的存在下经受高温时，这种衍生物抑制影响全氟聚醚链的降解过程。
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公开(公告)号：US06388133B1
公开(公告)日：2002-05-14
申请号：US09230970
申请日：1999-12-09
IPC分类号： C07C23305
CPC分类号： C07C235/74
摘要： A process for the preparation of an N,N-disubstituted-2-fluoro-1,3-ketoamide having the formula RCO.CFR′CONR2″ comprises treating an N,N-disubstituted-1,3-ketoamide having the formula RCO.CHR′CONR2″ with elemental fluorine. The groups R, R′ and R″ are independently selected from alkyl, aryl, substituted aryl, cycloalkyl, and substituted cycloalkyl. The group R′ may also be nitro or chlorine.
摘要翻译： 制备具有式RCO.CFR'CONR2“的N，N-二取代-2-氟-1,3-酮酰胺的方法包括处理具有式RCO的N，N-二取代-1,3-酮酰胺 .CHR'CONR2“与元素氟。 基团R，R'和R“独立地选自烷基，芳基，取代的芳基，环烷基和取代的环烷基。 基团R'也可以是硝基或氯。
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公开(公告)号：US06255518B1
公开(公告)日：2001-07-03
申请号：US09463268
申请日：2000-03-20
IPC分类号： C07F940
CPC分类号： C07F9/4037 , C07F9/4006
摘要： A method for the preparation of a fluorinated Phosphonate having the formula (RO)2PO CFR′R″ comprises treating a phosphonate of the formula (RO)2PO CHR′R″, or a metal salt thereof, with fluorine. R is an alkyl group R′ is hydrogen or alkyl and R″ is hydrogen, alkyl or another group.
摘要翻译： 制备具有式（RO）2 PO CFR'R“的氟化膦酸酯的方法包括用氟处理式（RO）2 POCHR'R”的膦酸酯或其金属盐。 R是烷基，R'是氢或烷基，R“是氢，烷基或另一个基团。
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公开(公告)号：US6031139A
公开(公告)日：2000-02-29
申请号：US11415
申请日：1998-02-05
IPC分类号： C07C45/63 , C07C45/51 , C07C45/54 , C07C49/167
CPC分类号： C07C45/54 , C07C45/511
摘要： The use of polar organic solvent as the solvent in the direct fluorination, to make an .alpha.-fluoroketone, of an enol ester or enol trialkylsilyl ether of a compound containing a tautomerisable ketone group, the solvent being relatively inert to fluorine and one in which the enol ester or enol trialkylsilyl ether is relatively stable to hydrolysis. Preferably the solvent is anhydrous, e.g. anhydrous acetonitrile. Alternatively commercial formic acid containing 3% water may be used with a said enol ester.
摘要翻译： PCT No.PCT / GB97 / 01547 Sec。 371日期：1998年2月5日 102（e）日期1998年2月5日PCT提交1997年6月6日PCT公布。 WO97 / 46508 PCT出版物 日期1997年12月11日在直接氟化中使用极性有机溶剂作为溶剂，制备含有可互变异构酮基的化合物的烯醇酯或烯醇三烷基甲硅烷基的α-氟代酮，该溶剂对氟相对惰性 其中烯醇酯或烯醇三烷基甲硅烷基醚对水解相对稳定。 优选地，溶剂是无水的，例如 无水乙腈。 或者可以使用含有3％水的商业甲酸与所述烯醇酯一起使用。
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