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公开(公告)号:US4857659A
公开(公告)日:1989-08-15
申请号:US38814
申请日:1987-04-15
申请人: Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
发明人: Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
IPC分类号: C07C51/09 , C07C59/64 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C319/20 , C07C323/62 , C07D307/33
CPC分类号: C07D307/33 , C07C51/09
摘要: The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio-.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.
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公开(公告)号:US4990526A
公开(公告)日:1991-02-05
申请号:US872309
申请日:1986-06-09
IPC分类号: A61K38/00 , C07D257/04 , C07D311/24 , C07K5/06 , A61K31/19 , A61K31/41
CPC分类号: C07D257/04 , C07C323/00 , C07D311/24 , C07K5/0606 , A61K38/00
摘要: Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis, and inhibitors of their biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, anti-psoriatic agents, and cytoprotective agents.
摘要翻译: 具有下式的化合物:(I)
是C4,D4和E4的白细胞三烯的拮抗剂,过敏反应的缓慢反应物质及其生物合成的抑制剂。 这些化合物可用作抗哮喘,抗过敏,抗炎药,抗牛皮癣药和细胞保护剂。 -
公开(公告)号:US5204358A
公开(公告)日:1993-04-20
申请号:US818598
申请日:1992-01-09
IPC分类号: C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D401/12 , C07D405/12 , C07D409/10 , C07D409/12
CPC分类号: C07D401/12 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D405/12 , C07D409/10 , C07D409/12
摘要: Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
摘要翻译: 具有下式的化合物:白三烯拮抗剂和白三烯生物合成抑制剂。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。
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公开(公告)号:US5104882A
公开(公告)日:1992-04-14
申请号:US527236
申请日:1990-05-22
IPC分类号: C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D401/12 , C07D405/12 , C07D409/10 , C07D409/12
CPC分类号: C07D401/12 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/36 , C07D405/12 , C07D409/10 , C07D409/12
摘要: Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
摘要翻译: 具有下式的化合物:白三烯拮抗剂和白三烯生物合成抑制剂。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。
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公开(公告)号:US5136034A
公开(公告)日:1992-08-04
申请号:US593836
申请日:1990-10-05
IPC分类号: C07C319/14 , C07C319/18 , C07C323/60 , C07D215/18
CPC分类号: C07C323/60 , C07C319/14 , C07C319/18 , C07D215/18
摘要: Thioacids, thiols, an acid, and an aldehyde are used to produce chiral thioacetals of the general formula. ##STR1## The compounds are leukotriene antagonists.
摘要翻译: 硫酸,硫醇,酸和醛用于制备通式的手性硫代缩醛。 化合物是白三烯拮抗剂。
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公开(公告)号:US4983628A
公开(公告)日:1991-01-08
申请号:US292706
申请日:1989-01-03
IPC分类号: A61K31/215 , C07C59/90 , C07D307/93
CPC分类号: C07D307/93 , C07C317/00 , C07C323/00 , C07C59/90
摘要: Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reaction substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译: 具有下式的化合物:(I)
是C4,D4和E4的白细胞三烯的拮抗剂,其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。 -
公开(公告)号:US4683325A
公开(公告)日:1987-07-28
申请号:US661560
申请日:1984-10-17
IPC分类号: C07C59/90 , C07D307/93 , C07C149/40
CPC分类号: C07D307/93 , C07C317/00 , C07C323/00 , C07C59/90
摘要: Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译: 具有下式的化合物:I是C4,D4和E4的白细胞三烯的拮抗剂,其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。
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公开(公告)号:US4918092A
公开(公告)日:1990-04-17
申请号:US144343
申请日:1988-01-15
IPC分类号: C07D307/80 , C07D319/20 , C07D321/10
CPC分类号: C07D319/20 , C07D307/80 , C07D321/10
摘要: Compounds having the formula I: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.
摘要翻译: 具有式I的化合物:I是C4,D4和E4的白细胞三烯的拮抗剂,其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘,抗过敏和抗炎剂。
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公开(公告)号:US4962203A
公开(公告)日:1990-10-09
申请号:US393436
申请日:1989-08-14
IPC分类号: C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D401/12
CPC分类号: C07D401/12 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36
摘要: Compounds having the formula: ##STR1## are selective antagonists of leukotrienes of D.sub.4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
摘要翻译: 具有下式的化合物:
是D4的白三烯的选择性拮抗剂。 这些化合物可用作抗哮喘,抗过敏,抗炎和细胞保护剂。 -
公开(公告)号:US5017583A
公开(公告)日:1991-05-21
申请号:US159631
申请日:1988-02-23
IPC分类号: A61K31/47 , A61K38/00 , C07C205/38 , C07D215/54 , C07D303/40 , C07D307/85 , C07D309/30 , C07D309/40 , C07D311/14 , C07D311/16 , C07D311/22 , C07D311/24 , C07D333/08 , C07D333/24 , C07D405/14 , C07D409/12 , C07F7/18 , C07K5/06
CPC分类号: C07D405/14 , C07C205/38 , C07C323/00 , C07D215/54 , C07D303/40 , C07D307/85 , C07D309/30 , C07D309/40 , C07D311/14 , C07D311/16 , C07D311/22 , C07D311/24 , C07D333/08 , C07D333/24 , C07D409/12 , C07F7/1856 , C07K5/0606 , A61K38/00
摘要: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
摘要翻译: 式Ⅰ化合物及其药学上可接受的盐是白三烯拮抗剂。 这些化合物抑制SRS-A和白细胞三烯合成,并且是SRS-A的拮抗剂,因此可用于治疗哮喘,过敏性疾病,炎症,皮肤疾病和某些心血管疾病。
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