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公开(公告)号：US4983628A
公开(公告)日：1991-01-08
申请号：US292706
申请日：1989-01-03
IPC分类号： A61K31/215 , C07C59/90 , C07D307/93
CPC分类号： C07D307/93 , C07C317/00 , C07C323/00 , C07C59/90
摘要： Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reaction substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 具有下式的化合物：（I）
是C4，D4和E4的白细胞三烯的拮抗剂，其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 -
公开(公告)号：US4683325A
公开(公告)日：1987-07-28
申请号：US661560
申请日：1984-10-17
IPC分类号： C07C59/90 , C07D307/93 , C07C149/40
CPC分类号： C07D307/93 , C07C317/00 , C07C323/00 , C07C59/90
摘要： Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 具有下式的化合物：I是C4，D4和E4的白细胞三烯的拮抗剂，其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US4857659A
公开(公告)日：1989-08-15
申请号：US38814
申请日：1987-04-15
申请人： Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
发明人： Richard Frenette , Jacques-Yves Gauthier , Robert N. Young , Robert Zamboni , Masatoshi Kakushima , Thomas R. Verhoeven
IPC分类号： C07C51/09 , C07C59/64 , C07C67/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C319/20 , C07C323/62 , C07D307/33
CPC分类号： C07D307/33 , C07C51/09
摘要： The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio-.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.
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公开(公告)号：US4918092A
公开(公告)日：1990-04-17
申请号：US144343
申请日：1988-01-15
IPC分类号： C07D307/80 , C07D319/20 , C07D321/10
CPC分类号： C07D319/20 , C07D307/80 , C07D321/10
摘要： Compounds having the formula I: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic and anti-inflammatory agents.
摘要翻译： 具有式I的化合物：I是C4，D4和E4的白细胞三烯的拮抗剂，其是过敏反应的缓慢反应物质。 这些化合物可用作抗哮喘，抗过敏和抗炎剂。
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公开(公告)号：US4990526A
公开(公告)日：1991-02-05
申请号：US872309
申请日：1986-06-09
IPC分类号： A61K38/00 , C07D257/04 , C07D311/24 , C07K5/06 , A61K31/19 , A61K31/41
CPC分类号： C07D257/04 , C07C323/00 , C07D311/24 , C07K5/0606 , A61K38/00
摘要： Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis, and inhibitors of their biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, anti-psoriatic agents, and cytoprotective agents.
摘要翻译： 具有下式的化合物：（I）
是C4，D4和E4的白细胞三烯的拮抗剂，过敏反应的缓慢反应物质及其生物合成的抑制剂。 这些化合物可用作抗哮喘，抗过敏，抗炎药，抗牛皮癣药和细胞保护剂。 -
公开(公告)号：US4962203A
公开(公告)日：1990-10-09
申请号：US393436
申请日：1989-08-14
IPC分类号： C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D401/12
CPC分类号： C07D401/12 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36
摘要： Compounds having the formula: ##STR1## are selective antagonists of leukotrienes of D.sub.4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.
摘要翻译： 具有下式的化合物：
是D4的白三烯的选择性拮抗剂。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 -
7.发明申请Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use 审中-公开二苯基取代的环烷烃，含有这些化合物的组合物和使用方法公开(公告)号：US20090197883A1
公开(公告)日：2009-08-06
申请号：US11885851
申请日：2006-03-03
申请人： Helen M. Armstrong , Linda L. Chang , Richard Frenette , Dwight MacDonald , Hyun O. Ok , Michel Therien , Feroze Ujjainwalla
发明人： Helen M. Armstrong , Linda L. Chang , Richard Frenette , Dwight MacDonald , Hyun O. Ok , Michel Therien , Feroze Ujjainwalla
IPC分类号： A61K31/5377 , C07D417/02 , A61K31/4439 , C07D401/02 , A61K31/4709 , C07D413/02 , C07D403/02 , A61K31/506 , C07D487/02 , A61K31/519 , A61P29/00 , A61P9/10
CPC分类号： C07D487/04 , C07D215/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D513/04
摘要： The instant invention provides compounds of Formula (I) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式（I）化合物。 式（I）的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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8.发明申请公开(公告)号：US20060211677A1
公开(公告)日：2006-09-21
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号： C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
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公开(公告)号：US06204275B1
公开(公告)日：2001-03-20
申请号：US09513149
申请日：2000-02-25
申请人： Richard Friesen , Yvbes Ducharme , Daniel Dube , Yves Girard , Richard Frenette , Chun Li , Marc Blouin , Nathalie Chauret , Laird Trimble
发明人： Richard Friesen , Yvbes Ducharme , Daniel Dube , Yves Girard , Richard Frenette , Chun Li , Marc Blouin , Nathalie Chauret , Laird Trimble
IPC分类号： C07D40102
CPC分类号： C07D213/30 , C07D213/89 , C07D417/14
摘要： The invention encompasses compounds of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.
摘要翻译： 本发明包括通过抑制磷酸二酯酶IV（PDE IV）提高环腺苷-3'，5'-单磷酸（cAMP）的水平，可用于治疗疾病（包括哮喘）的式I化合物。本发明还包括 通过抑制PDE IV治疗疾病的某些药物组合物和方法，导致cAMP升高，包括使用式I化合物。
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10.发明申请DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 审中-公开二苯基取代的环己烷，包含这些化合物的组合物和使用方法公开(公告)号：US20100152185A1
公开(公告)日：2010-06-17
申请号：US12632286
申请日：2009-12-07
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
IPC分类号： A61K31/4709 , C07D215/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D277/64 , A61K31/47 , A61K31/5377 , A61K31/4439 , A61K31/428
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。 式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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