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公开(公告)号：US5750510A
公开(公告)日：1998-05-12
申请号：US832741
申请日：1997-04-04
申请人： Richard L. Elliott , Yat Sun Or , Daniel T. Chu , George W. Griesgraber , Jacob J. Plattner , Daisy Pireh
发明人： Richard L. Elliott , Yat Sun Or , Daniel T. Chu , George W. Griesgraber , Jacob J. Plattner , Daisy Pireh
CPC分类号： C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity.
摘要翻译： 具有抗菌活性的新型3-脱水氨基-2,3-脱水红霉素化合物及其药学上可接受的盐和酯。
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2.发明授权
公开(公告)号：US6028181A
公开(公告)日：2000-02-22
申请号：US186395
申请日：1998-11-04
申请人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
发明人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
IPC分类号： A61K31/70 , A61K31/7048 , A61P31/04 , C07H17/00 , C07H17/08
摘要： Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 具有下式的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US5866549A
公开(公告)日：1999-02-02
申请号：US888350
申请日：1997-07-03
申请人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
发明人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
摘要： Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： （IV），（IV）或（VI）所示的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：USRE39591E1
公开(公告)日：2007-04-24
申请号：US10752483
申请日：2004-01-06
申请人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
发明人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
摘要： Antimicrobial compounds having the formula as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 具有下式的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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5.发明授权
公开(公告)号：US6147197A
公开(公告)日：2000-11-14
申请号：US185903
申请日：1998-11-04
申请人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
发明人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
IPC分类号： A61K31/70 , A61K31/7048 , A61P31/04 , C07H17/00 , C07H17/08
摘要： Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 具有下式的抗微生物化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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6.发明授权
公开(公告)号：US6075133A
公开(公告)日：2000-06-13
申请号：US185883
申请日：1998-11-04
申请人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
发明人： Yat Sun Or , Zhenkun Ma , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner , George Griesgraber
IPC分类号： A61K31/70 , A61K31/7048 , A61P31/04 , C07H17/00 , C07H17/08
摘要： Antimicrobial compounds having the formula as well as pharmaceutically acceptable sats, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译： 具有下式的抗微生物化合物及其药学上可接受的sats，酯或前药，包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。
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公开(公告)号：US5780605A
公开(公告)日：1998-07-14
申请号：US925582
申请日：1997-09-08
申请人： Yat Sun Or , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner
发明人： Yat Sun Or , Richard F. Clark , Daniel T. Chu , Jacob J. Plattner
IPC分类号： A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , A61K31/70
CPC分类号： C07H17/08
摘要： Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having a formula ##STR1## compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.
摘要翻译： 具有抗细菌活性的新型多环红霉素化合物及其药学上可接受的盐和酯具有式（I），（II），图像（III）的组合物，包含治疗有效量的本发明化合物 与药学上可接受的载体的组合，以及通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物来治疗细菌感染的方法。
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公开(公告)号：US5624924A
公开(公告)日：1997-04-29
申请号：US254801
申请日：1994-06-06
申请人： Daniel T. Chu , Jacob J. Plattner , Robert Hallas
发明人： Daniel T. Chu , Jacob J. Plattner , Robert Hallas
IPC分类号： C07D471/04 , A61K31/435 , A61K31/535 , A61K31/54 , A61P35/00 , C07D455/03 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04 , C07D513/06 , C07D279/36
CPC分类号： C07D498/06 , C07D455/00 , C07D498/16 , C07D513/06 , Y02P20/55
摘要： Quinobenzothiazine derivatives of the formula ##STR1## as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R.sup.1 is hydrogen or acarboxy-protecting group, R.sup.2 and R.sup.3 are substitutents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.
摘要翻译： 公开了具有式“IMAGE”的喹苯并噻嗪衍生物及其药学上可接受的盐，酯，酰胺和前药，其中R 1是氢或酰氧基保护基，R 2和R 3是取代基，A是氧，硫或碳， Z是卤素或含氮基团，X是氢，卤素或烷基，W是氢，烷基，氨基或卤素。 这些化合物具有有效的抗肿瘤活性。
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公开(公告)号：US5599816A
公开(公告)日：1997-02-04
申请号：US482249
申请日：1995-06-07
申请人： Daniel T. Chu , Qun Li , Curt S. Cooper , Anthony K. L. Fung , Cheuk M. Lee , Jacob J. Plattner , Zhenkun Ma , Wei-Bo Wang
发明人： Daniel T. Chu , Qun Li , Curt S. Cooper , Anthony K. L. Fung , Cheuk M. Lee , Jacob J. Plattner , Zhenkun Ma , Wei-Bo Wang
IPC分类号： A61K38/00 , C07D213/61 , C07D213/68 , C07D455/02 , C07D471/04 , C07D491/16 , C07D519/00 , C07K5/06 , A61K31/495 , A61K31/44 , A61K31/505 , A61K31/535 , C07D471/02 , C07D487/00 , C07D498/02
CPC分类号： C07D471/04 , C07D213/61 , C07D213/68 , C07D455/02 , C07K5/06026 , A61K38/00
摘要： Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds whereinA is.dbd.CR.sup.6 --;R.sup.1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl;R.sup.2 is selected from the group consisting of ##STR2## R.sup.3 is halogen; R.sup.4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group;R.sup.5 is hydrogen, loweralkyl, halo(loweralkyl), or --NR.sup.13 R.sup.14 ; andR.sup.6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl),as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
摘要翻译： 具有式（I）的抗菌化合物及其药学上可接受的盐，酯和酰胺，其选择的优选实例包括其中A = CR 6 - 的那些化合物; R1是3至8个碳原子的环烷基或取代的苯基; R2选自
R3是卤素; R4是氢，低级烷基，药学上可接受的阳离子或前药酯基; R5为氢，低级烷基，卤代（低级烷基）或-NR13R14; 并且R6是卤素，低级烷基，卤代（低级烷基），羟基取代的低级烷基，低级烷氧基（低级烷基），低级烷氧基或氨基（低级烷基），以及含有这些化合物的药物组合物及其用于治疗细菌感染 。 -
公开(公告)号：US5318965A
公开(公告)日：1994-06-07
申请号：US842910
申请日：1992-02-27
申请人： Daniel T. Chu , Jacob J. Plattner , Robert Hallas
发明人： Daniel T. Chu , Jacob J. Plattner , Robert Hallas
IPC分类号： C07D471/04 , A61K31/435 , A61K31/535 , A61K31/54 , A61P35/00 , C07D455/03 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04 , C07D513/06
CPC分类号： C07D498/06 , C07D455/00 , C07D498/16 , C07D513/06 , Y02P20/55
摘要： Quinobenzoxazine, derivatives of the formula ##STR1## as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R.sup.1 is hydrogen or a carboxy-protecting group, R.sup.2 and R.sup.3 are substitutents, A is oxygen, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.
摘要翻译： 公开了喹啉酮恶嗪，式IMA的衍生物及其药学上可接受的盐，酯，酰胺和前药，其中R1是氢或羧基保护基，R2和R3是取代基，A是氧，Z是 卤素或含氮基团，X为氢，卤素或烷基，W为氢，烷基，氨基或卤素。 这些化合物具有有效的抗肿瘤活性。
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