专利检索 ap:("Richard L. Mackman" OR "Jay P. Parrish" OR "Adrian S. Ray" OR "Dorothy Agnes Theodore") AND inv:"Jay P. Parrish" 第 1 页

1.

发明申请
METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS 审中-公开
标题翻译：用于治疗寄生虫病毒感染的方法和化合物

公开(公告)号：US20120027752A1

公开(公告)日：2012-02-02

申请号：US13189373

申请日：2011-07-22

申请人： Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dorothy Agnes Theodore

发明人： Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dorothy Agnes Theodore

IPC分类号： A61K31/706 , C07H19/04 , A61P31/12 , A61K39/395

CPC分类号： C07D487/04 , A61K9/0078 , A61K31/706 , A61K45/06 , C07F9/6561 , C07H7/06 , C07H19/04

摘要： Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

摘要翻译： 本发明提供了通过给予式I的核糖苷，其核苷糖苷及其前体药物来治疗副粘病毒科病毒感染的方法：其中核苷糖的1'位置被取代。提供的化合物，组合物和方法特别可用于治疗人类副流感和人类呼吸道合胞病毒感染。

2.

发明申请
ANTIVIRAL COMPOUNDS 有权
标题翻译：有害化合物

公开(公告)号：US20120264711A1

公开(公告)日：2012-10-18

申请号：US13491446

申请日：2012-06-07

申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

IPC分类号： A61K31/4178 , C07D495/04 , A61P1/16 , A61K31/7068 , A61P31/14 , A61K31/7052 , A61K31/4184 , A61K31/7056

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及抗病毒化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

3.

发明授权
Antiviral compounds 有权

公开(公告)号：US08088368B2

公开(公告)日：2012-01-03

申请号：US12779023

申请日：2010-05-12

申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Scott E. Lazerwith , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , William J. Watkins , Lianhong Xu

发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Scott E. Lazerwith , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , William J. Watkins , Lianhong Xu

IPC分类号： A61K31/4178 , A61K31/435 , A61K31/55 , A61K31/438 , A61K31/496 , A61K31/5415 , A61K31/708 , A61K31/7052 , A61K38/21 , C07D403/14 , C07D401/14 , C07D417/14 , A61P31/14

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

4.

发明授权
Pyrazolo[1,5-a]pyrimidines for antiviral treatment 有权
标题翻译：吡唑并[1,5-a]嘧啶用于抗病毒治疗

公开(公告)号：US08486938B2

公开(公告)日：2013-07-16

申请号：US13167618

申请日：2011-06-23

申请人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang

发明人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang

IPC分类号： C07D487/04 , A61K31/519

CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616

摘要： The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

摘要翻译： 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。其化合物及其组合物可用于治疗肺炎链球菌病毒感染。提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。

5.

发明申请
ANTIVIRAL COMPOUNDS 有权

公开(公告)号：US20120157404A1

公开(公告)日：2012-06-21

申请号：US13291977

申请日：2011-11-08

申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu

IPC分类号： A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

6.

发明申请
PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT 有权
标题翻译：吡咯并[1,5-A]用于抗病毒治疗的吡咯烷酮

公开(公告)号：US20120003215A1

公开(公告)日：2012-01-05

申请号：US13167618

申请日：2011-06-23

申请人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang

发明人： Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang

IPC分类号： A61K31/519 , C07D413/14 , A61P31/14 , A61K31/7056 , A61K39/42 , C07D487/04 , A61K31/5377

CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616

摘要： The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

摘要翻译： 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。其化合物及其组合物可用于治疗肺炎链球菌病毒感染。提供的化合物，组合物和方法特别可用于治疗人呼吸道合胞病毒感染。