利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.018 秒)

    2-Amino-5-spiro substituted oxazoline-4-one compounds
    4.
    发明授权
    2-Amino-5-spiro substituted oxazoline-4-one compounds 失效
    2-氨基-5-螺取代的恶唑啉-4-酮化合物

    公开(公告)号：US3931198A

    公开(公告)日：1976-01-06

    申请号：US333599

    申请日：1973-02-20

    申请人： Michael Raymond Harnden

    发明人： Michael Raymond Harnden

    IPC分类号： C07D263/52 ,  C07D211/18

    CPC分类号： C07D263/52

    摘要： A novel series of 2-amino-5-spiro substituted oxazolin-4-ones and intermediates for making said compounds. These compounds are prepared by first converting the appropriately substituted cycloketone to the corresponding cyclocyanohydrin; converting this compounds to the corresponding hydroxy acid; esterifying the hydroxy acid, and finally cyclizing the hydroester to form the 2-amino-5-spiro substituted oxazolin-4-one. These compounds exhibit central nervous system activity and are active as either stimulants or depressants, and some are useful as performance enhancers.

    摘要翻译： 一系列2-氨基-5-螺取代的恶唑啉-4-酮和制备所述化合物的中间体。 这些化合物是通过首先将适当取代的环酮转化为相应的环状甘油醇来制备的; 将该化合物转化为相应的羟基酸; 酯化羟基酸，最后环化水解形成2-氨基-5-螺取代的恶唑啉-4-酮。 这些化合物显示出中枢神经系统活性，并且作为兴奋剂或抑制剂是有活性的，一些可用作性能增强剂。

    Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
    5.
    发明授权
    Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones 失效
    抗病毒2-氨基-5- {8 1-（吲哚-3-基）烷基{9,2-噻唑啉-4-酮

    公开(公告)号：US4049816A

    公开(公告)日：1977-09-20

    申请号：US666662

    申请日：1976-03-15

    申请人： Michael Raymond Harnden ,  Nicholas David Wright

    发明人： Michael Raymond Harnden ,  Nicholas David Wright

    IPC分类号： C07D417/06 ,  C07D209/18 ,  C07D275/02

    CPC分类号： C07D209/18

    摘要： Thiazolinone analogues of indolmycin having anti-viral activity as well as a degree of antibacterial and antimycoplasmal activity in contrast to the known indolmycin which has only some antibacterial activity. Tautomers and a single enantiomer or mixture of enantiomers are included. Intermediates are described which are cyclized to produce the active antiviral substances. Suitable dosage forms and amounts are set forth and various routes of administration included including administration to the respiratory tract as by insufflation or inhalation.

    摘要翻译： 具有抗病毒活性的吲哚霉素的噻唑啉酮类似物以及与仅具有一些抗菌活性的已知的吲哚霉素相反的一定程度的抗细菌和抗支原体活性。 包括Tautomers和单一对映异构体或对映异构体混合物。 描述了环化以产生活性抗病毒物质的中间体。 阐述合适的剂量形式和量，并包括各种给药途径，包括通过吹入或吸入给予呼吸道。