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    Capillary electrophoresis apparatus and electrophoresis method
    4.
    发明申请
    Capillary electrophoresis apparatus and electrophoresis method 有权
    毛细管电泳仪和电泳法

    公开(公告)号：US20070163882A1

    公开(公告)日：2007-07-19

    申请号：US11653332

    申请日：2007-01-16

    申请人： Motohiro Yamazaki ,  Ryoji Inaba ,  Satoshi Takahashi ,  Isao Haraura ,  Tomoyuki Sakai

    发明人： Motohiro Yamazaki ,  Ryoji Inaba ,  Satoshi Takahashi ,  Isao Haraura ,  Tomoyuki Sakai

    IPC分类号： C07K1/26 ,  G01N27/00

    CPC分类号： G01N27/44704 ,  G01N27/44721

    摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.

    摘要翻译： 本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。 本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。 在本发明的毛细管电泳装置中设置毛细管位置测定光源。 用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。 基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

    Capillary electrophoresis apparatus and electrophoresis method
    5.
    发明授权
    Capillary electrophoresis apparatus and electrophoresis method 有权
    毛细管电泳仪和电泳法

    公开(公告)号：US08012327B2

    公开(公告)日：2011-09-06

    申请号：US11653332

    申请日：2007-01-16

    申请人： Motohiro Yamazaki ,  Ryoji Inaba ,  Satoshi Takahashi ,  Isao Haraura ,  Tomoyuki Sakai

    发明人： Motohiro Yamazaki ,  Ryoji Inaba ,  Satoshi Takahashi ,  Isao Haraura ,  Tomoyuki Sakai

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44704 ,  G01N27/44721

    摘要： An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal while spectral data acquisition is eliminated in each capillary exchange. The invention relates to a capillary electrophoresis apparatus in which capillary position shift is detected in each capillary exchange by detecting a capillary position. A capillary position measuring light source is provided in the capillary electrophoresis apparatus of the invention. The capillary is irradiated with light emitted from the capillary position measuring light source, a capillary image is detected with a two-dimensional detector, and thereby a position deviation of the capillary is determined. On the basis of the position deviation of the capillary, a data acquisition area is set in the two-dimensional detector, or a reference fluorescent light spectrum determined from the capillary at the standard position is corrected.

    摘要翻译： 本发明的目的是提供一种毛细管电泳装置，其中在每个毛细管交换中消除光谱数据采集时，可以在灵敏度和数据采集之间确保同时性，以减小上拉信号。 本发明涉及一种毛细管电泳装置，其中通过检测毛细管位置在每个毛细管交换中检测毛细管位置偏移。 在本发明的毛细管电泳装置中设置毛细管位置测定光源。 用从毛细管位置测量光源发射的光照射毛细管，用二维检测器检测毛细管图像，从而确定毛细管的位置偏差。 基于毛细管的位置偏差，在二维检测器中设置数据获取区域，或者校正从标准位置处的毛细管确定的参考荧光光谱。

    Method of electrophoresis, electrophoresis apparatus and capillary array
    8.
    发明授权
    Method of electrophoresis, electrophoresis apparatus and capillary array 有权
    电泳方法，电泳装置和毛细管阵列

    公开(公告)号：US07316770B2

    公开(公告)日：2008-01-08

    申请号：US09814860

    申请日：2001-03-23

    申请人： Ryoji Inaba ,  Tomoyuki Sakai ,  Satoshi Takahashi ,  Muneo Maeshima ,  Miho Ozawa ,  Masaya Kojima ,  Daizo Tokinaga

    发明人： Ryoji Inaba ,  Tomoyuki Sakai ,  Satoshi Takahashi ,  Muneo Maeshima ,  Miho Ozawa ,  Masaya Kojima ,  Daizo Tokinaga

    IPC分类号： G01N27/26

    CPC分类号： G01N27/44708 ,  G01N27/44782

    摘要： A method of electrophoresis, an electrophoresis apparatus and a capillary array in which a fluorescently labelled sample is supplied into capillaries in a capillary array constituted by a plurality of capillaries and including a sample supply portion, an electrophoresis medium supply portion and a detection portion while controlling the temperature of the capillary array through gas circulation, the sample is caused to migrate and separated in the capillaries through electrophoresis, and at the region where the capillaries are contacted or come close each other a plurality of capillaries are contacted to a solid body so as to dissipate heat generated from the capillaries to the solid body.

    摘要翻译： 一种电泳方法，电泳装置和毛细管阵列，其中荧光标记的样品被供应到由多个毛细管构成的毛细管阵列的毛细管中，并且包括样品供应部分，电泳介质供应部分和检测部分，同时控制 通过气体循环的毛细管阵列的温度，通过电泳使样品在毛细管中迁移和分离，并且在毛细管接触或彼此靠近的区域，多个毛细管与固体接触，以便 以将从毛细管产生的热量散发到固体。

    Electrophoretic apparatus and electrophoretic method
    10.
    发明授权
    Electrophoretic apparatus and electrophoretic method 有权
    电泳仪和电泳法

    公开(公告)号：US08545686B2

    公开(公告)日：2013-10-01

    申请号：US11397890

    申请日：2006-04-05

    申请人： Ryoji Inaba ,  Tomoyuki Sakai ,  Motohiro Yamazaki ,  Takashi Gomi ,  Kazumichi Imai

    发明人： Ryoji Inaba ,  Tomoyuki Sakai ,  Motohiro Yamazaki ,  Takashi Gomi ,  Kazumichi Imai

    IPC分类号： G01N27/453 ,  G01N27/447

    CPC分类号： G01N27/44721 ,  G01N27/44782

    摘要： The present invention relates to detection of an emission spectrum by irradiating excitation light onto a plurality of electrophoretic paths and dispersing fluorescent light output from the electrophoretic paths in a direction approximately vertical to an electrophoretic direction. According to the invention, since an emission spectrum to be detected does not substantially change over time, it becomes possible to make observed emission spectrums completely correspond to various fluorescent dyes or various bases.

    摘要翻译： 本发明涉及通过将激发光照射到多个电泳路径上并且将电泳路径输出的荧光以大致垂直于电泳方向的方向分散的方式来检测发射光谱。 根据本发明，由于要检测的发射光谱随时间基本上不变化，因此可以使观察到的发射光谱完全对应于各种荧光染料或各种基底。