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    4-phenylpiperidine derivatives as renin inhibitors
    1.
    发明授权
    4-phenylpiperidine derivatives as renin inhibitors 失效
    4-苯基哌啶衍生物作为肾素抑制剂

    公开(公告)号：US08362040B2

    公开(公告)日：2013-01-29

    申请号：US12789892

    申请日：2010-05-28

    申请人： Richard Sedrani ,  Juergen Klaus Maibaum ,  Werner Breitenstein ,  Holger Sellner ,  Claus Ehrhardt ,  Nils Ostermann

    发明人： Richard Sedrani ,  Juergen Klaus Maibaum ,  Werner Breitenstein ,  Holger Sellner ,  Claus Ehrhardt ,  Nils Ostermann

    IPC分类号： A01N43/40 ,  A61K31/445 ,  C07D211/40 ,  C07D211/54

    CPC分类号： C07D401/10 ,  C07D211/42 ,  C07D405/04 ,  C07D409/10

    摘要： Compounds of the present invention having the formula exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

    摘要翻译： 具有下式的本发明化合物对天然酶肾素表现出抑制活性。 因此，式（I）化合物可用于治疗高血压，动脉粥样硬化，不稳定冠状动脉综合征，充血性心力衰竭，心脏肥大，心脏纤维化，心肌梗塞后梗死，冠状动脉综合征不稳定，舒张功能障碍，慢性肾脏疾病，肝纤维化， 糖尿病引起的并发症如肾病，血管病变和神经病变，冠状血管疾病，血管成形术后再狭窄，眼内压升高，青光眼，异常血管生长，醛固酮增多症，认知障碍，阿尔茨海默病，痴呆，焦虑状态和认知障碍。

    4-Phenylpiperidine derivatives as renin inhibitors
    3.
    发明申请
    4-Phenylpiperidine derivatives as renin inhibitors 审中-公开
    4-苯基哌啶衍生物作为肾素抑制剂

    公开(公告)号：US20070078164A1

    公开(公告)日：2007-04-05

    申请号：US10580296

    申请日：2004-11-25

    申请人： Richard Sedrani ,  Juergen-Klaus Maibaum ,  Werner Breitenstein ,  Holger Sellner ,  Claus Ehrhardt ,  Nils Ostermann

    发明人： Richard Sedrani ,  Juergen-Klaus Maibaum ,  Werner Breitenstein ,  Holger Sellner ,  Claus Ehrhardt ,  Nils Ostermann

    IPC分类号： A61K31/454 ,  C07D401/02

    CPC分类号： C07D401/10 ,  C07D211/42 ,  C07D405/04 ,  C07D409/10

    摘要： Compounds of the present invention having the formula exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

    摘要翻译： 具有下式的本发明化合物对天然酶肾素表现出抑制活性。 因此，式（I）化合物可用于治疗高血压，动脉粥样硬化，不稳定冠状动脉综合征，充血性心力衰竭，心脏肥大，心脏纤维化，心肌梗塞后梗死，冠状动脉综合征不稳定，舒张功能障碍，慢性肾脏疾病，肝纤维化， 糖尿病引起的并发症如肾病，血管病变和神经病变，冠状血管疾病，血管成形术后再狭窄，眼内压升高，青光眼，异常血管生长，醛固酮增多症，认知障碍，阿尔茨海默病，痴呆，焦虑状态和认知障碍。