公开(公告)号：US06734012B2

公开(公告)日：2004-05-11

申请号：US09899607

申请日：2001-07-05

申请人： Rita Andreoli ,  Murtaza Amin ,  Mark Meyering ,  Richard Chesterson ,  Eugene Ostreicher

发明人： Rita Andreoli ,  Murtaza Amin ,  Mark Meyering ,  Richard Chesterson ,  Eugene Ostreicher

IPC分类号： C12M134

CPC分类号： C07H21/00 ,  B01J2219/00274 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C40B40/00 ,  G01N33/54353 ,  G01N33/54393 ,  G01N33/545 ,  G01N33/551

摘要： An improved combination non-luminescent microporous membrane and solid support for use in micro-analytical diagnostic applications is disclosed. Specifically, composite microarray non-luminescent slides having a microporous membrane effectively attached by covalent bonding through a surface treatment to a substrate that prepares the substrate to sufficiently, covalently bond to the non-luminescent microporous membrane formed by a phase inversion process such that the combination produced thereby is useful in microarray applications and wherein the porous non-luminescent nylon composite microarray slides are covalently bonded to a solid base member, such as, for example, a glass or Mylar microscope slide, such that the combination produced thereby is useful in microarray applications. Apparatus and methods for fabricating lithe non-luminescent composite microarray slides are also disclosed.

摘要翻译： 公开了一种用于微分析诊断应用的改进的非发光微孔膜和固体支持物。 具体而言，具有通过表面处理共价键连接的微孔膜的复合微阵列非发光载玻片与制备基板的基板充分地共价键合到通过相转化方法形成的非发光微多孔膜，使得组合 由此产生的生物可用于微阵列应用，并且其中多孔非发光尼龙复合微阵列载片共价键合到固体基底部件，例如玻璃或Mylar显微镜载玻片上，使得由此产生的组合可用于微阵列 应用程序。 还公开了用于制造未发光复合微阵列载玻片的装置和方法。

公开(公告)号：US20050173334A1

公开(公告)日：2005-08-11

申请号：US11035245

申请日：2005-01-13

申请人： Rita Andreoli ,  Richard Chesterson

发明人： Rita Andreoli ,  Richard Chesterson

IPC分类号： C07B61/00 ,  C07H21/00 ,  G01N33/543 ,  G01N33/545 ,  G01N33/551 ,  B01D71/00

CPC分类号： C07H21/00 ,  B01J2219/00274 ,  B01J2219/00576 ,  B01J2219/00641 ,  B01J2219/00722 ,  C07B2200/11 ,  C40B40/00 ,  G01N33/54393 ,  G01N33/545 ,  G01N33/551

摘要： A substantially non-reflective, low or non-fluorescing substrate comprising a phase-inversion support and a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and of a size sufficient to be partially or completely contained within, or intimately bound to, the phase inversion support. Methods of making and using the substantially non-reflective, low or non-fluorescing substrate are also disclosed.