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公开(公告)号：US20050272736A1
公开(公告)日：2005-12-08
申请号：US11123324
申请日：2005-05-06
申请人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
发明人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/498 , A61K31/519 , C07D401/06 , C07D405/04 , C07D417/04 , C07D417/14 , C07D471/02 , C07D471/04 , C07D487/02 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
CPC分类号： C07D471/04 , C07D401/06 , C07D405/04 , C07D417/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X′, Y, Y′, Z, and Z′ are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 其中R 1或R 2的式（I）化合物是三环或双环，其各自含有至少两个杂原子，R 1，R 2， R 2，R 2，R 3，R 3a，R 3b，R 4， R 3，R 5，L，X，X'，Y，Y'，Z和Z'如本文所定义，可用于治疗组胺3阻止或改善的病症或病症 受体配体。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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2.发明申请Bicyclic-substituted amines having cyclic-substituted monocyclic substituents 审中-公开具有环取代的单环取代基的双环取代的胺公开(公告)号：US20050256118A1
公开(公告)日：2005-11-17
申请号：US10843742
申请日：2004-05-12
申请人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
发明人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
IPC分类号： A61K31/4709 , C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/497 , C07D49/14
CPC分类号： C07D215/12 , C07D401/04 , C07D401/08 , C07D401/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X′, Y, Y′, Z, Z′, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 其中R 1或R 2的式（I）化合物是由L 2直接连接或连接的芳族或非芳族环， X，X'，Y，Y'，Z，Z'，R 1，R 3， R 3，R 3，R 3a，R 3b，R 4，R 3， 5，L，L 2和L 3 3如本文所定义，可用于治疗组胺3受体配体预防或改善的病症或病症 。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20060194798A1
公开(公告)日：2006-08-31
申请号：US11418699
申请日：2006-05-05
申请人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Padam Sharma , Youssef Bennani , Michael Curtis
发明人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Padam Sharma , Youssef Bennani , Michael Curtis
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/4709 , A61K31/427 , C07D417/02 , C07D403/02
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20050272728A1
公开(公告)日：2005-12-08
申请号：US11123620
申请日：2005-05-06
申请人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
发明人： Robert Altenbach , Lawrence Black , Sou-Jen Chang , Marlon Cowart , Ramin Faghih , Gregory Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill Lukin , Diana Nersesian , Yu-ming Pu , Michael Curtis
IPC分类号： A61K31/4709 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X′, Y, Y′, Z, Z′, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：US20110098285A1
公开(公告)日：2011-04-28
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/40 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/4709 , A61K31/501 , A61P25/28 , A61P11/06 , A61P25/00 , A61P25/16 , A61P3/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/30 , A61P3/10 , A61P3/04
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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6.发明授权公开(公告)号：US07098222B2
公开(公告)日：2006-08-29
申请号：US11123620
申请日：2005-05-06
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Michael P. Curtis
IPC分类号： A61K31/47 , A61K31/40 , C07D215/12 , C07D401/04 , C07D207/09
CPC分类号： C07D409/14 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X′, Y, Y′, Z, Z′, R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 其中R 1或R 2的式（I）化合物是由L 2直接连接或连接的芳族或非芳族环， X，X'，Y，Y'，Z，Z'，R 1，R 3， R 3，R 3，R 3a，R 3b，R 4，R 3， 5，L，L 2和L 3 3如本文所定义，可用于治疗组胺3受体配体预防或改善的病症或病症 。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20090054420A1
公开(公告)日：2009-02-26
申请号：US12196124
申请日：2008-08-21
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/541 , C07D207/09 , C07D401/02 , C07D413/02 , C07D239/02 , C07D277/02 , C07D403/02 , C07D417/02 , C07D403/14 , A61P3/00 , A61P35/00 , A61P11/06 , A61P25/00 , A61P9/00 , A61K31/4725 , A61K31/4709 , A61K31/40 , A61K31/4439 , A61K31/422 , A61K31/506 , A61K31/5377 , A61K31/426 , A61K31/501
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US08273767B2
公开(公告)日：2012-09-25
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US07153889B2
公开(公告)日：2006-12-26
申请号：US10689735
申请日：2003-10-22
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07C13/465
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：US20080119520A1
公开(公告)日：2008-05-22
申请号：US12022041
申请日：2008-01-29
申请人： Marlon Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie Fernando , Timothy Grieme , Robert Altenbach
发明人： Marlon Cowart , Yi-Yin Ku , Sou-Jen Chang , Dilinie Fernando , Timothy Grieme , Robert Altenbach
IPC分类号： A61K31/454 , C07D417/02 , A61K31/428 , C07D401/14 , A61K31/4439 , A61P35/00 , A61P25/00 , A61P25/16 , A61P25/28 , C07D413/02 , A61K31/423 , C07D401/02
CPC分类号： C07D263/56 , C07D209/14 , C07D235/14 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such compounds and compositions.
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物和使用这些化合物和组合物的方法。
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