公开(公告)号：US20050220772A1

公开(公告)日：2005-10-06

申请号：US10498450

申请日：2002-11-27

申请人： Robert Chow ,  Denis Rodgerson ,  Rubio Punzalan ,  Lawrence Petz

发明人： Robert Chow ,  Denis Rodgerson ,  Rubio Punzalan ,  Lawrence Petz

IPC分类号： A61K48/00 ,  A61K35/12 ,  A61K38/00 ,  A61P31/18 ,  A61P37/04 ,  C12N5/0789

CPC分类号： C12N5/0647 ,  A61K2035/124

摘要： This invention provides methods for preventing or treating any disease arising from HIV infection, including AIDS and AIDS-related complex (ARC). The method comprises screening a plurality of donors to identify stem cells with a beneficial gene or genes and then transplanting the therapeutic stem cells into a patient. In preferred embodiments, the beneficial gene encodes a polymorphism that renders cells refractory to HIV infection. The polymorphism may be for a gene that encodes a ligand of a receptor for HIV entry, a product of the HLA complex, or a receptor for HIV entry. The Invention also provides isolated populations of stem cells with beneficial genes for resisting infections.

摘要翻译： 本发明提供了预防或治疗HIV感染引起的任何疾病的方法，包括AIDS和AIDS相关复合物（ARC）。 该方法包括筛选多个供体以鉴定具有有益基因或基因的干细胞，然后将治疗性干细胞移植到患者体内。 在优选的实施方案中，有益基因编码使得细胞难以感染HIV的多态性。 多态性可以是编码HIV进入受体的配体的基因，HLA复合物的产物或HIV进入的受体。 本发明还提供具有用于抵抗感染的有益基因的分离的干细胞群。

公开(公告)号：US20060233768A1

公开(公告)日：2006-10-19

申请号：US11396238

申请日：2006-03-30

申请人： Thomas Hirose ,  Simon Lam ,  Rubio Punzalan ,  Denis Rodgerson

发明人： Thomas Hirose ,  Simon Lam ,  Rubio Punzalan ,  Denis Rodgerson

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： C12N5/0607 ,  A61K35/12 ,  A61K2035/124 ,  C12N5/0647

摘要： An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or “pre-disease” state, for future distribution for his or her healthcare needs. The process includes methods of collection, processing, preservation and distribution of adult (including pediatric) peripheral blood stem cells during non-diseased state. The stem cells collected will contain adequate dosage amounts, for one or more transplantations immediately when needed by the individual for future healthcare treatments. The collected adult or non-neonate child peripheral blood stem cells can be aliquoted into defined dosage fractions before cryopreservation so that cells can be withdrawn from storage without the necessity of thawing all of the collected cells.

摘要翻译： 使用个人自己的外周血干细胞作为个人未来医疗保健用途的选择性医疗保险模式。 当他或她处于健康或“疾病前”状态时，个人可以选择收集，加工和保存自己的干细胞，以便将来分配他或她的医疗保健需求。 该过程包括在非疾病状态下收集，处理，保存和分配成人（包括小儿）外周血干细胞的方法。 收集的干细胞将含有足够的剂量，用于个体为将来的保健治疗需要时立即进行一次或多次移植。 收集的成年或非新生儿儿童外周血干细胞可以在冷冻保存之前等分到确定的剂量组分中，使得细胞可以从储存中取出，而不需要解冻所有收集的细胞。

公开(公告)号：US20140112891A1

公开(公告)日：2014-04-24

申请号：US14110230

申请日：2012-04-09

申请人： Russell Taichman ,  Paul H. Krebsbach ,  Aaron Havens ,  Anjali Mishra ,  Denis Rodgerson ,  Jingcheng Wang ,  Yusuke Shiozawa ,  Younghun Jung

发明人： Russell Taichman ,  Paul H. Krebsbach ,  Aaron Havens ,  Anjali Mishra ,  Denis Rodgerson ,  Jingcheng Wang ,  Yusuke Shiozawa ,  Younghun Jung

IPC分类号： A61K35/28

CPC分类号： A61K35/28 ,  A61K35/545 ,  A61K38/1875 ,  A61L27/24 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/06 ,  C12N5/0607 ,  A61K2300/00

摘要： The invention provides methods and compositions for the repair or regeneration of osteochondral tissue. The methods and compositions provide an effective amount of isolated differentiable human Very Small Embryonic Like Stem Cells (hVSELs) sufficient for regeneration or repair of an osteochondral tissue. The compositions can be administered directly to the tissue or administered systemically.

摘要翻译： 本发明提供了用于修复或再生骨软骨组织的方法和组合物。 所述方法和组合物提供了足够用于骨软骨组织再生或修复的有效量的可分离的人类非常小的类似胚胎干细胞（hVSEL）。 组合物可以直接施用于组织或全身施用。

公开(公告)号：US20080038231A1

公开(公告)日：2008-02-14

申请号：US11763655

申请日：2007-06-15

申请人： Denis Rodgerson ,  George Smith ,  Ronald Allin ,  Wayne Marasco

发明人： Denis Rodgerson ,  George Smith ,  Ronald Allin ,  Wayne Marasco

IPC分类号： A61K35/12 ,  A61P35/00 ,  A61P37/00 ,  A61P7/00 ,  C12N5/08

CPC分类号： C12N5/0647 ,  A61K35/28 ,  A61K38/193

摘要： An elective healthcare insurance model using an individual's own peripheral blood stem cells for the individual's future healthcare uses. An individual can elect to have his or her own stem cells collected, processed and preserved, while he or she is in healthy or “pre-disease” state, for future distribution for his or her healthcare needs. The process includes methods of collection, processing, preservation and distribution of adult (including pediatric) peripheral blood stem cells during non-diseased state. The stem cells collected will contain adequate dosage amounts, for one or more transplantations immediately when needed by the individual for future healthcare treatments. The collected adult or non-neonate child peripheral blood stem cells can be aliquoted into defined dosage fractions before cryopreservation so that cells can be withdrawn from storage without the necessity of thawing all of the collected cells.

摘要翻译： 使用个人自己的外周血干细胞作为个人未来医疗保健用途的选择性医疗保险模式。 当他或她处于健康或“疾病前”状态时，个人可以选择收集，加工和保存自己的干细胞，以便将来分配他或她的医疗保健需求。 该过程包括在非疾病状态下收集，处理，保存和分配成人（包括小儿）外周血干细胞的方法。 收集的干细胞将含有足够的剂量，用于个体为将来的保健治疗需要时立即进行一次或多次移植。 收集的成年或非新生儿儿童外周血干细胞可以在冷冻保存之前等分到确定的剂量组分中，使得细胞可以从储存中取出，而不需要解冻所有收集的细胞。