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公开(公告)号:US06197812B1
公开(公告)日:2001-03-06
申请号:US09440248
申请日:1999-11-15
IPC分类号: A61K31341
CPC分类号: C07D307/18 , A61K31/5585 , C07D307/20 , C07D493/04
摘要: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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2.substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives 失效
标题翻译: 前列腺素的取代四氢呋喃类似物作为眼睛低血压公开(公告)号:US6025392A
公开(公告)日:2000-02-15
申请号:US109852
申请日:1998-07-02
IPC分类号: C07D307/12 , A61K31/34 , A61K31/341 , A61K31/557 , A61K31/5585 , A61P27/02 , A61P27/06 , A61P43/00 , C07D307/02 , C07D307/14 , C07D307/18 , C07D307/20 , C07D407/06 , C07D493/04
CPC分类号: C07D307/18 , A61K31/5585 , C07D307/20 , C07D493/04
摘要: Substituted tetrahydrofuran analogs of F-series prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了F系列前列腺素的取代四氢呋喃类似物及其用于治疗青光眼和高眼压症的方法。
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3.11-halo prostaglandins for the treatment of glaucoma or ocular hypertension 失效
标题翻译: 用于治疗青光眼或高眼压症的11-halo前列腺素公开(公告)号:US06353000B1
公开(公告)日:2002-03-05
申请号:US09284533
申请日:1999-06-02
IPC分类号: A01N4316
CPC分类号: C07C405/0016 , A61K31/5575 , C07C405/00
摘要: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
摘要翻译: 一种治疗患者的青光眼或高眼压症的方法,其包括向患者施用药学有效量的式I化合物:
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4.15-ketal postaglandins for the treatment of glaucoma or ocular hypertension 失效
标题翻译: 15-ketal postaglandins用于治疗青光眼或高眼压症公开(公告)号:US06353014B1
公开(公告)日:2002-03-05
申请号:US09284534
申请日:1999-06-02
IPC分类号: A01N4338
CPC分类号: A61K31/5575 , A61K31/5585
摘要: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
摘要翻译: 一种治疗患者的青光眼或高眼压症的方法,其包括向患者施用药学有效量的式I化合物:
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5.Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension 失效
标题翻译: 使用某些前列腺素类似物治疗青光眼和高眼压症公开(公告)号:US5807892A
公开(公告)日:1998-09-15
申请号:US480706
申请日:1995-06-07
IPC分类号: A61K31/557 , A61K31/5575 , C07C405/00 , A61K31/695 , A61K31/35 , C07C177/00
CPC分类号: A61K31/5575 , A61K31/557 , C07C405/0016
摘要: Certain prostaglandin analogues are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandin analogues.
摘要翻译: 某些前列腺素类似物可用于治疗青光眼和高眼压症。 还公开了包含这种前列腺素类似物的眼科药物组合物。
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公开(公告)号:US5698733A
公开(公告)日:1997-12-16
申请号:US480707
申请日:1995-06-07
IPC分类号: A61K31/557 , A61K31/5575 , A61P9/12 , C07C405/00 , C07C69/76
CPC分类号: A61K31/5575 , C07C405/00 , C07C405/0016
摘要: Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
摘要翻译: 公开了可用于治疗青光眼和高眼压症的9-脱氧前列腺素。 这些9-脱氧前列腺素中的一些是新颖的。 还公开了包含这种前列腺素的眼科药物组合物。
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公开(公告)号:US06680339B2
公开(公告)日:2004-01-20
申请号:US10100399
申请日:2002-03-18
申请人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
发明人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
IPC分类号: A61K31216
CPC分类号: C07C405/00 , A61K31/5575
摘要: 15-fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了PGF2α的15-氟取代类似物及其用于治疗青光眼和高眼压症的方法。
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公开(公告)号:US06649653B1
公开(公告)日:2003-11-18
申请号:US09284432
申请日:1999-06-02
申请人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
发明人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
IPC分类号: A61K31216
CPC分类号: A61K31/5575 , C07C405/00
摘要: 15-Fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了PGF2α的15-氟取代类似物及其用于治疗青光眼和高眼压症的方法。
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公开(公告)号:US20120115870A1
公开(公告)日:2012-05-10
申请号:US13348376
申请日:2012-01-11
申请人: Debra L. Fleenor , Iok-Hou Pang , Allan R. Shepard , Mark R. Hellberg , Peter G. Klimko , Abbot F. Clark
发明人: Debra L. Fleenor , Iok-Hou Pang , Allan R. Shepard , Mark R. Hellberg , Peter G. Klimko , Abbot F. Clark
IPC分类号: A61K31/5377 , C07D401/14 , A61K31/4439 , A61K31/437 , C07D471/04 , A61P27/02 , A61K31/506 , A61P27/06 , A61K31/519 , C07D417/12 , A61K31/495 , C07D413/12 , C07D413/14 , C12Q1/02 , C07D405/14
CPC分类号: G01N33/5008 , A61K31/357 , A61K31/381 , A61K31/4192 , A61K31/4196 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K45/06 , G01N33/5023 , G01N33/5044 , A61K2300/00
摘要: An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.
摘要翻译: 公开了一种可用于治疗青光眼和控制眼内压的眼用药物组合物,其包含有效量的ALK5受体活性的选择性调节剂。 还公开了一种治疗青光眼并控制眼内压的方法,其包括将治疗有效量的包含ALK5受体活性的选择性调节剂的药物组合物施用于患者的受影响的眼睛。
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10.Superoxide dismutase mimics for the treatment of ocular disorders and diseases 有权
标题翻译: 超氧化物歧化酶用于治疗眼部疾病和疾病公开(公告)号:US08003635B2
公开(公告)日:2011-08-23
申请号:US12766332
申请日:2010-04-23
IPC分类号: A61K31/555
CPC分类号: A61K31/555 , Y10S514/912
摘要: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
摘要翻译: 公开了使用SOD模拟,特别是五唑环Mn(II)复合物SOD模拟物,用于治疗AMD,DR和视网膜水肿。
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