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1.发明授权Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension 失效使用某些前列腺素类似物治疗青光眼和高眼压症
公开(公告)号：US5807892A
公开(公告)日：1998-09-15
申请号：US480706
申请日：1995-06-07
IPC分类号： A61K31/557 , A61K31/5575 , C07C405/00 , A61K31/695 , A61K31/35 , C07C177/00
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/0016
摘要： Certain prostaglandin analogues are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandin analogues.
摘要翻译： 某些前列腺素类似物可用于治疗青光眼和高眼压症。 还公开了包含这种前列腺素类似物的眼科药物组合物。
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公开(公告)号：US5698733A
公开(公告)日：1997-12-16
申请号：US480707
申请日：1995-06-07
IPC分类号： A61K31/557 , A61K31/5575 , A61P9/12 , C07C405/00 , C07C69/76
CPC分类号： A61K31/5575 , C07C405/00 , C07C405/0016
摘要： Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
摘要翻译： 公开了可用于治疗青光眼和高眼压症的9-脱氧前列腺素。 这些9-脱氧前列腺素中的一些是新颖的。 还公开了包含这种前列腺素的眼科药物组合物。
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3.发明授权公开(公告)号：US06169111A
公开(公告)日：2001-01-02
申请号：US09308052
申请日：1999-05-12
IPC分类号： A61K31557
CPC分类号： C07C405/0016 , A61K31/557 , A61K31/5575 , C07C405/00
摘要： Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
摘要翻译： 构形刚性的前列腺素可用于治疗青光眼和高眼压症。 还公开了包含所述前列腺素的眼用药物组合物。
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4.发明申请COMPOUNDS WITH 5-HT1A ACTIVITY USEFUL FOR TREATING DISORDERS OF THE OUTER RETINA 审中-公开具有5-HT1A活性的化合物可用于治疗外周疾病公开(公告)号：US20100168121A1
公开(公告)日：2010-07-01
申请号：US12719152
申请日：2010-03-08
IPC分类号： A61K31/506 , A61K31/496 , A61K31/428 , A61K31/4418 , A61K31/438 , A61K31/4433 , A61K31/135 , A61P27/02
CPC分类号： A61K31/519 , A61K31/496 , A61K31/506 , Y10S514/912
摘要： Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
摘要翻译： 公开了用具有5-HT1A激动剂活性的化合物治疗外部视网膜疾病的组合物和方法。
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5.发明授权Compounds with 5-HT1A activity useful for treating disorders of the outer retina 失效具有5-HT1A活性的化合物，可用于治疗外部视网膜疾病公开(公告)号：US07763619B2
公开(公告)日：2010-07-27
申请号：US11187474
申请日：2005-07-22
IPC分类号： A61K31/497
CPC分类号： A61K31/519 , A61K31/496 , A61K31/506 , Y10S514/912
摘要： Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
摘要翻译： 公开了用具有5-HT1A激动剂活性的化合物治疗外部视网膜疾病的组合物和方法。
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公开(公告)号：US06664286B1
公开(公告)日：2003-12-16
申请号：US09787332
申请日：2001-03-15
IPC分类号： A61K31405
CPC分类号： A61K31/4045 , A61K31/00 , Y10S514/913
摘要： Compounds with 5HT2 receptor agonist activity useful for treating glaucoma, including lowering intraocular pressure. Compositions and methods for their use are also disclosed.
摘要翻译： 具有5HT2受体激动剂活性的化合物，可用于治疗青光眼，包括降低眼内压。 还公开了其使用的组合物和方法。
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7.发明授权Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders 有权用于治疗眼睛和CNS疾病的5-羟色胺能5HT7受体化合物公开(公告)号：US07285553B2
公开(公告)日：2007-10-23
申请号：US11265030
申请日：2005-11-02
IPC分类号： C07D403/00 , C07D401/00 , C07D241/04 , A61K31/495
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
摘要翻译： 公开了可用于降低IOP，改善视神经头和视网膜的血流量，提供神经保护和治疗视网膜疾病的具有5HT 7受体亲和力（其中一些是新颖的）的化合物。 化合物还可用于治疗睡眠障碍，抑郁症和其他精神病学障碍，例如精神分裂症，焦虑症，强迫症，昼夜节律紊乱以及中枢和外周介导的高血压。 还公开了其使用的组合物和方法。
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公开(公告)号：US06344478B2
公开(公告)日：2002-02-05
申请号：US09777409
申请日：2001-02-06
IPC分类号： A61K31557
CPC分类号： C07C405/00 , A61K9/0048 , A61K31/557 , A61K31/5575 , A61K31/558 , A61K45/06 , C07C405/0025 , Y10S514/912 , Y10S514/913 , A61K2300/00
摘要： Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
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公开(公告)号：US5932572A
公开(公告)日：1999-08-03
申请号：US920314
申请日：1997-08-27
IPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , A61K31/535
CPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , Y10S514/913
摘要： Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor to reduce the production of aqueous humor, preferably formulated as a suspension having a pH between about 6.8 and about 7.8. These compositions may additionally contain a mucomimetic anionic polymer and/or a finely-divided drug carrier substrate to provide sustained release. A method of controlling elevated intraocular pressure with these compositions is also described.
摘要翻译： 描述了可用于控制与青光眼和高眼压症相关的升高的眼内压的眼用药物组合物。 组合物包含β-阻断剂和碳酸酐酶抑制剂的组合以减少房水的产生，优选配制为pH在约6.8至约7.8之间的悬浮液。 这些组合物可另外含有模拟阴离子聚合物和/或细碎药物载体底物以提供持续释放。 还描述了使用这些组合物来控制眼内压升高的方法。
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公开(公告)号：US5585377A
公开(公告)日：1996-12-17
申请号：US362716
申请日：1994-12-23
申请人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
发明人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
IPC分类号： C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/04 , A61K31/54
CPC分类号： C07D513/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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