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公开(公告)号:US20060113786A1
公开(公告)日:2006-06-01
申请号:US11138002
申请日:2005-05-27
申请人: Robert Desmarais , Kim Anzell , Phillip Yee , Joel Gordon , Gopalakrishnan Doraiswamy , Richard Koning , Ravinder Mann , David Arnold , Lawrence Refior
发明人: Robert Desmarais , Kim Anzell , Phillip Yee , Joel Gordon , Gopalakrishnan Doraiswamy , Richard Koning , Ravinder Mann , David Arnold , Lawrence Refior
IPC分类号: B60R22/20
CPC分类号: B60R22/203 , B60R13/025
摘要: A height adjuster for a vehicle safety restraint has a web guide (38) and a track (84) for the web guide. The web guide (38) is vertically moveable along the track (84). A lock (76) has a lock condition for preventing vertical movement of the web guide (38) along the track (84) and an unlocked condition for allowing vertical movement of the web guide (38) along the track (84). A release mechanism (50, 80) is operatively connectable to said lock (76). The release mechanism (50, 80) has a release position for placing the lock (76) in the unlocked condition and an unreleased position from maintaining the lock (76) in the lock condition. A lift mechanism (66) at least partially assists vertical movement of the web guide (38) along the track (84) and biases the release mechanism (50, 80) toward the unreleased position.
摘要翻译: 用于车辆安全限制器的高度调节器具有腹板引导件(38)和用于腹板引导件的轨迹(84)。 卷筒纸引导件(38)可沿轨道(84)垂直移动。 锁(76)具有用于防止卷筒纸引导件(38)沿着轨道(84)的垂直运动的锁定状态和用于允许卷筒纸导板(38)沿着轨道(84)的垂直运动的解锁状态。 释放机构(50,80)可操作地连接到所述锁(76)。 释放机构(50,80)具有用于将锁(76)放置在解锁状态的释放位置和从保持锁(76)处于锁定状态的未释放位置。 升降机构(66)至少部分地帮助卷筒纸引导件(38)沿着轨道(84)的垂直运动,并且将释放机构(50,80)朝向未打开的位置偏压。
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公开(公告)号:US07232154B2
公开(公告)日:2007-06-19
申请号:US11138002
申请日:2005-05-27
申请人: Robert J. Desmarais , Kim Anzell , Phillip Yee , Joel Gordon , Gopalakrishnan Doraiswamy , Richard Koning , Ravinder Mann , David R. Arnold , Lawrence M. Refior
发明人: Robert J. Desmarais , Kim Anzell , Phillip Yee , Joel Gordon , Gopalakrishnan Doraiswamy , Richard Koning , Ravinder Mann , David R. Arnold , Lawrence M. Refior
IPC分类号: B60R22/20
CPC分类号: B60R22/203 , B60R13/025
摘要: A height adjuster for a vehicle safety restraint has a web guide (38) and a track (84) for the web guide. The web guide (38) is vertically moveable along the track (84). A lock (76) has a lock condition for preventing vertical movement of the web guide (38) along the track (84) and an unlocked condition for allowing vertical movement of the web guide (38) along the track (84). A release mechanism (50, 80) is operatively connectable to said lock (76). The release mechanism (50, 80) has a release position for placing the lock (76) in the unlocked condition and an unreleased position from maintaining the lock (76) in the lock condition. A lift mechanism (66) at least partially assists vertical movement of the web guide (38) along the track (84) and biases the release mechanism (50, 80) toward the unreleased position.
摘要翻译: 用于车辆安全限制器的高度调节器具有腹板引导件(38)和用于腹板引导件的轨迹(84)。 卷筒纸引导件(38)可沿轨道(84)垂直移动。 锁(76)具有用于防止卷筒纸引导件(38)沿着轨道(84)的垂直运动的锁定状态和用于允许卷筒纸导板(38)沿着轨道(84)的垂直运动的解锁状态。 释放机构(50,80)可操作地连接到所述锁(76)。 释放机构(50,80)具有用于将锁(76)放置在解锁状态的释放位置和从保持锁(76)处于锁定状态的未释放位置。 升降机构(66)至少部分地帮助卷筒纸引导件(38)沿着轨道(84)的垂直运动,并且将释放机构(50,80)朝向未打开的位置偏压。
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公开(公告)号:US08461204B2
公开(公告)日:2013-06-11
申请号:US13566839
申请日:2012-08-03
申请人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
发明人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
IPC分类号: A61K31/198 , C07C323/24 , A61K31/197 , C07C323/59
CPC分类号: A61K31/197 , C07C323/59
摘要: Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, the compounds of the present invention act as inhibitors of edema, inhibitors of erythema and inhibitors of MPO (myeloperoxidase), pharmaceutical compositions containing the same compounds and the use thereof for the treatment of diseases that may benefit from edema, erythema and MPO inhibition, such as inflammation (acute or chronic), asthma, autoimmune diseases, and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis and small airways disease, etc.), inflammatory responses of the immune system, skin diseases (e.g., reducing acute skin irritation for patients suffering from rosacea, atopic dermatitis, seborrheic dermatitis, psoriasis), irritable bowel syndrome (e.g., Chron's disease and ulcerative colitis, etc.), and central nervous system disorders (e.g., Parkinson's disease).
摘要翻译: 除此之外,本发明提供能够有效抑制嗜中性粒细胞,巨噬细胞和血小板中G蛋白或GPCR介导的炎症反应的新型化合物。 特别地,本发明的化合物作为水肿抑制剂,红斑抑制剂和MPO抑制剂(髓过氧化物酶),含有相同化合物的药物组合物及其用于治疗可能受益于水肿,红斑和MPO的疾病的用途 抑制,如炎症(急性或慢性),哮喘,自身免疫性疾病和慢性阻塞性肺疾病(COPD)(例如肺气肿,慢性支气管炎和小气道疾病等),免疫系统的炎症反应,皮肤疾病 例如,对于患有酒渣鼻,特应性皮炎,脂溢性皮炎,牛皮癣的患者,肠易激综合征(例如,Chron氏病和溃疡性结肠炎等)以及中枢神经系统疾病(例如帕金森病)的患者减少急性皮肤刺激。
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公开(公告)号:US20170043699A1
公开(公告)日:2017-02-16
申请号:US15338514
申请日:2016-10-31
申请人: Joel Gordon
发明人: Joel Gordon
CPC分类号: B60P1/486 , B60P3/14 , B60R9/00 , B60R9/06 , B62D33/0273
摘要: A device for movably mounting a storage container in relation to the storage bed of a pickup truck. The device includes a container support frame with a mounting member configured to be fixedly secured in relation to the pickup truck storage bed, and a lift arm having a first end coupled to the container support frame for pivotal movement about a first pivot axis and a second end configured to be coupled to the storage container for pivotal movement about a second pivot axis. The second end of the lift arm is movable along an arcuate path about the first pivot axis between a stowed position in which the storage container is disposed between the side rails and an extended position in which the storage container is disposed above a side rail. The storage container is pivotable about the second pivot axis to maintain an upright orientation in the stowed and extended positions, providing a variety of convenient access and storage options. Also, the frame can be confined to a very small portion of the storage bed or hidden within existing components of the storage bed to allow substantially unimpeded top and rear access to the storage bed.
摘要翻译: 一种用于相对于皮卡车的存储床可移动地安装存储容器的装置。 该装置包括容器支撑框架,其具有构造成相对于皮卡车储存床固定地固定的安装构件,以及提升臂,其具有联接到容器支撑框架的第一端,用于围绕第一枢转轴线枢转运动,第二端 端部构造成联接到存储容器以用于围绕第二枢转轴线枢转运动。 提升臂的第二端可沿着围绕第一枢转轴线的弧形路径在可收容的位置之间移动,在收起位置之间存储容器设置在侧轨之间,在延伸位置,存储容器设置在侧轨上方。 存储容器可围绕第二枢转轴线枢转,以保持收起和延伸位置的直立定向,从而提供各种便利的存取和存储选项。 此外,框架可以限制在存储床的非常小的部分上或者隐藏在存储床的现有部件中,以允许基本上无阻碍的顶部和后部进入存储床。
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公开(公告)号:US20130310559A1
公开(公告)日:2013-11-21
申请号:US13760627
申请日:2013-02-06
申请人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号: C07D217/26 , C07D209/48 , C07D333/24 , C07D295/145 , C07C243/34 , C07C321/18 , C07D207/16
CPC分类号: A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译: 除此之外,本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物,化妆品,药妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此,本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。
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公开(公告)号:US20090155186A1
公开(公告)日:2009-06-18
申请号:US11921994
申请日:2006-06-13
申请人: Jeffry B. Stock , Joel Gordon , Maxwell Stock , Gregory Stock
发明人: Jeffry B. Stock , Joel Gordon , Maxwell Stock , Gregory Stock
IPC分类号: A61K31/195 , A61K31/19 , A61K31/60 , A61K31/16 , A61K31/66 , A61K31/095 , A61K9/12 , A61P37/00 , A61P29/00 , A61P11/00 , A61K31/27 , A61K31/4035 , A61P1/00
CPC分类号: A61K31/198 , A61K8/46 , A61K31/20 , A61K45/06 , A61K2800/75 , A61K2800/782 , A61Q19/00 , C07C323/59
摘要: The present invention relates to compositions containing signal transduction modulator compounds, to methods for treating or preventing inflammation, or promoting healthy joints, using the compounds and to kits for the same.
摘要翻译: 本发明涉及含有信号转导调节剂化合物的组合物,用于治疗或预防炎症或促进健康关节的方法,使用该化合物和用于其的试剂盒。
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公开(公告)号:US20050277694A1
公开(公告)日:2005-12-15
申请号:US11151174
申请日:2005-06-13
申请人: Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
发明人: Jeffry Stock , Joel Gordon , Maxwell Stock , Greg Stock
IPC分类号: A61K31/198 , A61K31/20
CPC分类号: A61K31/198 , A61K8/46 , A61K31/20 , A61K45/06 , A61K2800/75 , A61K2800/782 , A61Q19/00 , C07C323/59
摘要: The present invention relates to pharmaceutical, cosmetic and cosmeceutical topical compositions containing polyisoprenyl-protein inhibitor compounds and methods useful in the promotion of healthy epithelium and the treatment of epithelial-related conditions
摘要翻译: 本发明涉及含有聚异戊二烯基蛋白抑制剂化合物的药物,化妆品和药妆外用组合物以及用于促进健康上皮和治疗上皮相关病症的方法
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公开(公告)号:US09376383B2
公开(公告)日:2016-06-28
申请号:US13760627
申请日:2013-02-06
申请人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen
发明人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号: C07C321/18 , C07C323/59 , C07C335/08 , C07D209/18 , C07D209/48 , C07D217/26 , C07D295/145 , C07D307/54 , C07D333/24 , C07D243/34 , C07D207/16
CPC分类号: A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译: 除此之外,本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物,化妆品,药妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此,本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。
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公开(公告)号:US20160166875A1
公开(公告)日:2016-06-16
申请号:US14951521
申请日:2015-11-25
申请人: Joel Gordon
发明人: Joel Gordon
IPC分类号: A63B21/00 , A63B23/035 , A63B22/00
CPC分类号: A63B22/001 , A63B21/012 , A63B21/023 , A63B21/055 , A63B21/154 , A63B22/0015 , A63B22/0017 , A63B22/0056 , A63B22/0064 , A63B22/0664 , A63B2022/0051 , A63B2022/0682
摘要: An exercise device with a pair of upper links coupled to the frame and a pair of lower links pivotally coupled to the upper links is provided. A pair of pedals is received on a distal end of each of the lower links. A transfer system between the pair of upper links may include a first and a second pushrod, each with a first end pivotally coupled to each upper link and a second end opposite to the first end. A first and a second pivot arm, each pivotally coupled to the frame, may be included, each pivot arm receiving a respective pushrod. A pliable connector may be coupled to the first pivot arm and the second pivot arm, thus providing compliant reciprocating movement of the upper links.
摘要翻译: 提供了一种具有联接到框架的一对上连杆和枢转地联接到上连杆的一对下连杆的锻炼装置。 在每个下部连杆的远端上接收一对踏板。 一对上连杆之间的传送系统可以包括第一和第二推杆,每个推杆具有枢转地联接到每个上连杆的第一端和与第一端相对的第二端。 可以包括枢转地联接到框架的第一和第二枢转臂,每个枢转臂接收相应的推杆。 柔性连接器可以联接到第一枢转臂和第二枢转臂,从而提供上部连杆的顺应的往复运动。
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公开(公告)号:US20100184768A1
公开(公告)日:2010-07-22
申请号:US12616781
申请日:2009-11-12
申请人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
发明人: Jeffry B. Stock , Maxwell Stock , Keshava Rapole , Seung-Yub Lee , Michael Voronkov , Eduardo Perez , Joel Gordon , Shuyi Chen , Jinglong Chen
IPC分类号: A61K31/5375 , C07C321/18 , A61K31/197 , C07D209/32 , A61K31/405 , A61K31/225 , C07D207/16 , A61K31/4015 , A61K31/265 , C07D333/24 , A61K31/381 , C07D217/26 , A61K31/472 , C07D265/30 , C07C233/46 , A61K31/16 , A61P29/00
CPC分类号: A61K31/197 , A61K9/0014 , C07C243/34 , C07C321/18 , C07C323/59 , C07C335/08 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/48 , C07D217/26 , C07D243/34 , C07D295/145 , C07D307/54 , C07D333/24
摘要: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
摘要翻译: 除此之外,本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物,化妆品,药妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此,本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。
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