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公开(公告)号：US06355785B1
公开(公告)日：2002-03-12
申请号：US09429130
申请日：1999-10-28
申请人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
发明人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
IPC分类号： C07H2100
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , H01L23/293 , H01L2924/0002 , C12N2310/3521 , H01L2924/00
摘要： A method and compositions for treating viral infection (IV) vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
摘要翻译： 一种使用富含鸟苷酸的寡核苷酸来体外和体内治疗病毒感染（IV）的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷酸的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性和整合酶抑制活性的富含鸟嘌呤核苷酸的方法。
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2.发明授权公开(公告)号：US06323185B1
公开(公告)日：2001-11-27
申请号：US08682255
申请日：1996-07-17
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , H01L23/293 , H01L2924/0002 , C12N2310/3521 , H01L2924/00
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
摘要翻译： 一种使用富含鸟苷酸的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷酸的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性和整合酶抑制活性的富含鸟嘌呤核苷酸的方法。
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公开(公告)号：US6150339A
公开(公告)日：2000-11-21
申请号：US987574
申请日：1997-12-09
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , C07H21/00 , C12N15/1132 , C12N15/1133 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotides. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. They can be composed of at least about 40% guanosine nucleotides. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity.
摘要翻译： 一种用于使用富含鸟苷的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 它们可以由至少约40％的鸟苷核苷酸组成。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性的富含鸟苷酸的寡核苷酸的方法。
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公开(公告)号：US5567604A
公开(公告)日：1996-10-22
申请号：US145704
申请日：1993-10-28
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61P31/12 , C07H21/00 , C07H21/04 , C12N15/113 , C12N7/06
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , C07H21/00 , C12N15/1132 , C12N15/1133 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotides. The oligonucleotides are composed of at least about 50% guanosine nucleotides. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity.
摘要翻译： 一种用于使用富含鸟苷的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 所述寡核苷酸由至少约50％的鸟苷核苷酸组成。 还提供了富含鸟苷的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性的富含鸟苷酸的寡核苷酸的方法。
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公开(公告)号：US06184369B2
公开(公告)日：2001-02-06
申请号：US08535168
申请日：1995-10-23
IPC分类号： C07H2100
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , C12N2310/3521
摘要： The oligonucleotides have sufficient guanosine to form a guanosine tetrad and can be composed of at least about 40% guanosine nucleotides, the nucleotide sequence containing at least two runs of at least two guanosines. Some of the new oligonucleotides also contain phosphorothioate backbones and 3′ end modifications. Representative guanosine-rich oligonucleotides of the present invention demonstrate anti-viral activity in tissue culture against HSV-2, HIV-1, HCMV and FMLV, and show specific inhibition of bacterial RNA polymerase enzymes T7 and T3, the FMLV and HIV-1 reverse transcriptase enzyme and eukaryotic RNA polymerase.
摘要翻译： 寡核苷酸具有足够的鸟苷以形成鸟苷四核苷酸，并且可以由至少约40％的鸟苷核苷酸组成，该核苷酸序列含有至少两次至少两种鸟苷。 一些新的寡核苷酸还含有硫代磷酸酯骨架和3'端修饰。 本发明的代表性的富含鸟苷酸的寡核苷酸在针对HSV-2，HIV-1，HCMV和FMLV的组织培养物中表现出抗病毒活性，并且显示细菌RNA聚合酶T7和T3，FMLV和HIV-1反向的特异性抑制 转录酶和真核RNA聚合酶。
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