-
公开(公告)号：US06355785B1
公开(公告)日：2002-03-12
申请号：US09429130
申请日：1999-10-28
申请人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
发明人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
IPC分类号： C07H2100
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , H01L23/293 , H01L2924/0002 , C12N2310/3521 , H01L2924/00
摘要： A method and compositions for treating viral infection (IV) vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
摘要翻译： 一种使用富含鸟苷酸的寡核苷酸来体外和体内治疗病毒感染（IV）的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷酸的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性和整合酶抑制活性的富含鸟嘌呤核苷酸的方法。
-
公开(公告)号：US20090186359A1
公开(公告)日：2009-07-23
申请号：US12355328
申请日：2009-01-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： An assay for detecting prostate cancer includes reagents for detecting the methylation of GSTP1 and HIC-1 genes.
摘要翻译： 用于检测前列腺癌的测定法包括用于检测GSTP1和HIC-1基因的甲基化的试剂。
-
3.发明授权公开(公告)号：US06921638B2
公开(公告)日：2005-07-26
申请号：US10025185
申请日：2001-12-19
IPC分类号： B01J19/00 , C07F9/24 , C07F9/553 , C07F9/6503 , C07F9/6506 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N33/543 , C07H21/04 , C08J3/28
CPC分类号： G01N33/54353 , B01J19/0046 , B01J2219/00378 , B01J2219/00529 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07F9/2408 , C07F9/5532 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C12Q2523/319
摘要： Methods and devices for detecting nucleic acid and protein targets on hydrogel microarrays are disclosed. Fluorophores are incorporated into the targets and detected. A linear correlation between target concentration and signal amplitude is maintained through the elimination of active enzyme amplification.
摘要翻译： 公开了用于在水凝胶微阵列上检测核酸和蛋白质靶标的方法和装置。 荧光素掺入目标物中并进行检测。 通过消除活性酶扩增来维持目标浓度和信号幅度之间的线性相关性。
-
公开(公告)号：US20090186360A1
公开(公告)日：2009-07-23
申请号：US12355869
申请日：2009-01-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16
摘要： An assay for detecting prostate cancer includes reagents for detecting multiple methylation markers from within one gene such as GSTP1.
摘要翻译： 用于检测前列腺癌的测定法包括用于从一个基因（例如GSTP1）内检测多个甲基化标记物的试剂。
-
公开(公告)号：US20090047656A1
公开(公告)日：2009-02-19
申请号：US11717835
申请日：2007-03-13
申请人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
发明人： Jonathan F. Baden , Chang H. Choi , Dondapati Chowdary , Kathleen M. Curtin , Tatiana Vener , Haiying Wang , Christine A. Burnett , Abhijit Mazumder
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178
摘要： The present invention provides a method of propagating cells of interest obtained from a biological specimen by a) enriching the cells under conditions that maintain sufficient cell viability; and b) propagating the cells under conditions effective to allow cell viability, proliferation and integrity.
摘要翻译： 本发明提供一种通过以下步骤来繁殖生物样品获得的感兴趣的细胞：（a）在维持足够细胞活力的条件下使细胞富集; 和b）在有效允许细胞活力，增殖和完整性的条件下繁殖细胞。
-
公开(公告)号：US20070122818A1
公开(公告)日：2007-05-31
申请号：US11262667
申请日：2005-10-31
申请人： Abhijit Mazumder , Shobha Varde , Thomas Briggs
发明人： Abhijit Mazumder , Shobha Varde , Thomas Briggs
CPC分类号： C12Q1/6848 , C12Q1/6858 , C12Q1/6876 , C12Q2600/166 , C12Q2545/113 , C12Q2525/117 , C12Q2523/125
摘要： Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them.
摘要翻译： 用于评估甲基化测定的有效性的方法，组分和试剂盒如甲基化测定法所示，包括核苷酸序列控制和使用它们的方法。
-
公开(公告)号：US20070037186A1
公开(公告)日：2007-02-15
申请号：US11435266
申请日：2006-05-16
申请人： Yuqiu Jiang , John Backus , Abhijit Mazumder , Dondapati Chowdary , Fei Yang , Yixin Wang , Timothy Jatkoe
发明人： Yuqiu Jiang , John Backus , Abhijit Mazumder , Dondapati Chowdary , Fei Yang , Yixin Wang , Timothy Jatkoe
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154
摘要： The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes.
摘要翻译： 本发明涉及用于诊断甲状腺癌，区分甲状腺癌和良性甲状腺疾病的方法，组合物和制品，测定甲状腺结节的不确定甲状腺细针抽吸样品，并确定患者的方案和结果。
-
公开(公告)号：US07047141B2
公开(公告)日：2006-05-16
申请号：US09921045
申请日：2001-08-02
CPC分类号： C12Q1/6809 , B01J2219/00576 , B01J2219/00722 , C40B20/08 , C40B30/04 , C40B40/06 , C40B40/08 , C40B50/08 , C12Q2545/114 , C12Q2537/143
摘要： Disclosed herein are methods of selecting probes to target nucleic acid sequences, methods of making oligonucleotide arrays comprising such probes, and methods of using such arrays. Also, described herein are oligonucleotide arrays comprising probes selected by a method of the invention.
-
公开(公告)号：US20100003670A1
公开(公告)日：2010-01-07
申请号：US11929206
申请日：2007-10-30
申请人： Haiying Wang , Shobha Varde , Dondapati Chowdary , Jyoti Mehrotra , Tatiana Nener , Abhijit Mazumder
发明人： Haiying Wang , Shobha Varde , Dondapati Chowdary , Jyoti Mehrotra , Tatiana Nener , Abhijit Mazumder
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： Methods and kits for predicting the course or aggressiveness of prostate cancer include detecting the methylation status of various genes.
摘要翻译： 用于预测前列腺癌病程或侵袭性的方法和试剂盒包括检测各种基因的甲基化状态。
-
公开(公告)号：US07552013B2
公开(公告)日：2009-06-23
申请号：US11375981
申请日：2006-03-15
CPC分类号： C12Q1/6809 , B01J2219/00576 , B01J2219/00722 , C40B20/08 , C40B30/04 , C40B40/06 , C40B40/08 , C40B50/08 , C12Q2545/114 , C12Q2537/143
摘要： Disclosed herein are methods of selecting probes to target nucleic acid sequences, methods of making oligonucleotide arrays comprising such probes, and methods of using such arrays. Also, described herein are oligonucleotide arrays comprising probes selected by a method of the invention.
摘要翻译： 本文公开了选择靶核酸序列的探针的方法，制备包含这种探针的寡核苷酸阵列的方法，以及使用这种阵列的方法。 此外，本文描述的是包含通过本发明的方法选择的探针的寡核苷酸阵列。
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.04 秒)
