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公开(公告)号：US06355785B1
公开(公告)日：2002-03-12
申请号：US09429130
申请日：1999-10-28
申请人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
发明人： Robert F. Rando , Susan Fennewald , Joseph G. Zendegui , Joshua O. Ojwang , Michael E. Hogan , Yves Pommier , Abhijit Mazumder
IPC分类号： C07H2100
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , H01L23/293 , H01L2924/0002 , C12N2310/3521 , H01L2924/00
摘要： A method and compositions for treating viral infection (IV) vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
摘要翻译： 一种使用富含鸟苷酸的寡核苷酸来体外和体内治疗病毒感染（IV）的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷酸的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性和整合酶抑制活性的富含鸟嘌呤核苷酸的方法。
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2.发明授权公开(公告)号：US06323185B1
公开(公告)日：2001-11-27
申请号：US08682255
申请日：1996-07-17
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N15/1132 , C12N15/1133 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515 , H01L23/293 , H01L2924/0002 , C12N2310/3521 , H01L2924/00
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotide. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity and integrase inhibition activity.
摘要翻译： 一种使用富含鸟苷酸的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷酸的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性和整合酶抑制活性的富含鸟嘌呤核苷酸的方法。
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公开(公告)号：US6150339A
公开(公告)日：2000-11-21
申请号：US987574
申请日：1997-12-09
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , C07H21/00 , C12N15/1132 , C12N15/1133 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotides. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. They can be composed of at least about 40% guanosine nucleotides. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity.
摘要翻译： 一种用于使用富含鸟苷的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 寡核苷酸具有足够的鸟苷以形成鸟苷四肽。 它们可以由至少约40％的鸟苷核苷酸组成。 还提供了至少两次至少两种鸟苷的寡核苷酸。 还提供了富含鸟苷的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性的富含鸟苷酸的寡核苷酸的方法。
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公开(公告)号：US5567604A
公开(公告)日：1996-10-22
申请号：US145704
申请日：1993-10-28
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61P31/12 , C07H21/00 , C07H21/04 , C12N15/113 , C12N7/06
CPC分类号： A61K31/70 , A61K31/711 , A61K31/7115 , A61K31/7125 , C07H21/00 , C12N15/1132 , C12N15/1133 , A61K38/00 , C12N2310/151 , C12N2310/18 , C12N2310/315 , C12N2310/321 , C12N2310/33 , C12N2310/335 , C12N2310/351 , C12N2310/3515
摘要： A method and compositions for treating viral infection in vitro and in vivo using a guanosine-rich oligonucleotides. The oligonucleotides are composed of at least about 50% guanosine nucleotides. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans, and a method for designing guanosine-rich oligonucleotides having anti-viral activity.
摘要翻译： 一种用于使用富含鸟苷的寡核苷酸在体外和体内治疗病毒感染的方法和组合物。 所述寡核苷酸由至少约50％的鸟苷核苷酸组成。 还提供了富含鸟苷的寡核苷酸和用于治疗人类病毒感染的方法，以及设计具有抗病毒活性的富含鸟苷酸的寡核苷酸的方法。
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公开(公告)号：US6132962A
公开(公告)日：2000-10-17
申请号：US876996
申请日：1997-06-16
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent or a foreign nucleic acid under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译： 本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长末端重复序列之间插入编码抗-IV型特异性试剂或在pol III启动子控制下的外源核酸的核酸。 还提供了含有本发明的逆转录病毒载体的宿主细胞。 还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。
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公开(公告)号：US5811275A
公开(公告)日：1998-09-22
申请号：US465483
申请日：1995-06-05
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Mark Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Mark Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12N15/86
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译： 本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长的末端重复序列之间插入编码在pol III启动子控制下的抗HIV型特异性试剂的核酸。 还提供了含有本发明的逆转录病毒载体的宿主细胞。 还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。
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公开(公告)号：US5670361A
公开(公告)日：1997-09-23
申请号：US245742
申请日：1994-05-17
申请人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
发明人： Flossie Wong-Staal , Mang Yu , Osamu Yamada , Joshua O. Ojwang , Markley C. Leavitt , Anthony Ho
IPC分类号： C12N15/09 , A61K31/70 , A61K35/12 , A61K35/14 , A61K35/407 , A61K35/44 , A61K35/76 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C07H21/04 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/867 , C12R1/92 , C12N15/86 , C12N15/11
CPC分类号： C12N15/1132 , C12N15/86 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
摘要翻译： 本发明提供了一种感染性逆转录病毒，其在逆转录病毒的5'和3'长的末端重复序列之间插入编码在pol III启动子控制下的抗HIV型特异性试剂的核酸。 还提供了含有本发明的逆转录病毒载体的宿主细胞。 还提供了干扰或预防感染HIV或可能感染HIV的细胞中HIV病毒复制的方法。
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