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公开(公告)号：US07087897B2
公开(公告)日：2006-08-08
申请号：US10797242
申请日：2004-03-10
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an electric field region L2 wherein a time-varying electric field is applied thereto. In a mode of operation a pulse of ions 3 comprising ions having different mass to charge ratios passes through the electric field region L2 and the electric field is varied with time such that at least some of the ions 3 having different mass to charge ratios subsequently arrive at the extraction or acceleration region 10 of a Time of Flight mass analyser at substantially the same time.
摘要翻译： 公开了一种质谱仪，其包括施加时变电场的电场区域L 2。 在操作模式中，包含不同质荷比的离子的离子3的脉冲通过电场区L 2，并且电场随时间而变化，使得至少一些离子3 具有不同的质荷比随后在几乎相同的时间到达飞行时间质量分析仪的提取或加速区域10。
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公开(公告)号：US06794642B2
公开(公告)日：2004-09-21
申请号：US10636811
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J4926
CPC分类号： H01J49/42 , H01J49/004
摘要： A mass spectrometer is disclosed comprising at least first and second ion traps which are arranged in series. A relatively high AC or RF voltage is applied to the electrodes forming the first ion trap in order to improve the trapping of energetic or high mass to charge ratio ions. The relatively high AC or RF voltage applied to the first ion trap also has the effect of raising the low mass cut-off of the first ion trap. The second ion trap, arranged downstream of the first ion trap, is arranged to have a lower low mass cut-off than the first ion trap, and hence ions which are not trapped in the first ion trap are trapped in the second ion trap.
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公开(公告)号：US07205538B2
公开(公告)日：2007-04-17
申请号：US11472278
申请日：2006-06-22
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
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公开(公告)号：US07071467B2
公开(公告)日：2006-07-04
申请号：US10633702
申请日：2003-08-05
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
摘要翻译： 公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。 一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。 或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。
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公开(公告)号：US06770872B2
公开(公告)日：2004-08-03
申请号：US10301580
申请日：2002-11-22
IPC分类号： H01J4934
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap such as a 3D quadrupole field ion trap upstream of a pusher electrode of an orthogonal acceleration Time of Flight mass analyser. According to a first embodiment bunches of ions are released from the ion trap and the pusher electrode is energized after a delay time which is progressively varied. According to a second embodiment ions are released from the ion trap in reverse order of mass to charge ratio with the ions having the largest mass to charge ratio being released first. By appropriate release of the ions from the ion trap it is possible to ensure that substantially all of the ions arrive at the pusher electrode at substantially the same time. According to both embodiments it is possible to achieve a duty cycle approaching 100% across a large range of mass to charge ratios.
摘要翻译： 公开了一种质谱仪，其包括质量选择性离子阱，例如正交加速时间飞行质量分析仪的推进器电极上游的3D四极场离子阱。 根据第一实施例，一束离子从离子阱中释放出来，并且推进器电极在逐渐变化的延迟时间之后通电。 根据第二实施方案，离子从离子阱以与质荷比最大的离子的质荷比相反的顺序被释放。 通过从离子阱适当释放离子，可以确保基本上所有的离子基本上同时到达推动器电极。 根据两个实施例，可以实现在大范围的质荷比之间接近100％的占空比。
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公开(公告)号：US06906317B2
公开(公告)日：2005-06-14
申请号：US10733925
申请日：2003-12-11
CPC分类号： H01J43/246
摘要： An ion detector for a mass spectrometer is disclosed comprising one or more microchannel plates and an anode arranged to receive electrons emitted from the one or more microchannel plates. The anode is permanently magnetized and electrons emitted from the microchannel plates preferably spiral around lines of magnetic field towards the anode.
摘要翻译： 公开了一种用于质谱仪的离子检测器，其包括一个或多个微通道板和布置成接收从一个或多个微通道板发射的电子的阳极。 阳极被永久磁化，并且从微通道板发射的电子优选地绕着磁场线向着阳极旋转。
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公开(公告)号：US07202473B2
公开(公告)日：2007-04-10
申请号：US10821548
申请日：2004-04-09
申请人： Robert Harold Bateman , Jeff Brown , Martin Green
发明人： Robert Harold Bateman , Jeff Brown , Martin Green
CPC分类号： H01J49/0036
摘要： A mass spectrometer is disclosed wherein the experimentally determined mass to charge ratios of ions are reported together with an error band for each mass to charge ratio determination. The error band may, for example, reflect a 95% probability or confidence that the real, true, actual or accepted mass to charge ratio of the ion lies within the error band. By accurately determining the error band the possible candidate ions in a database can be accurately restricted whilst also guarding against over restriction.
摘要翻译： 公开了一种质谱仪，其中实验确定的离子质量与电荷比率与每个质荷比确定的误差带一起报告。 例如，误差带可以反映出真实的，真实的，实际的或接受的离子质量与电荷比在误差带内的概率或置信度。 通过精确地确定误差带，可以准确地限制数据库中的可能候选离子，同时也防止过度限制。
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公开(公告)号：US07157697B2
公开(公告)日：2007-01-02
申请号：US10734055
申请日：2003-12-11
CPC分类号： H01J43/246
摘要： An ion detector for a mass spectrometer is disclosed comprising one or more microchannel plates and an anode arranged to receive electrons emitted from the one or more microchannel plates. The anode preferably has a smaller diameter than the microchannel plates and is preferably arranged at a distance of at least 15 mm from the microchannel plates. One or more focusing lenses may be provided intermediate the microchannel plates and the anode. The anode preferably comprises two portions separated by an electrically insulated layer.
摘要翻译： 公开了一种用于质谱仪的离子检测器，其包括一个或多个微通道板和布置成接收从一个或多个微通道板发射的电子的阳极。 阳极优选具有比微通道板更小的直径，并且优选地布置在距离微通道板至少15mm的距离处。 可以在微通道板和阳极之间提供一个或多个聚焦透镜。 阳极优选包括由电绝缘层分开的两个部分。
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公开(公告)号：US07141785B2
公开(公告)日：2006-11-28
申请号：US10777609
申请日：2004-02-12
申请人： Robert Harold Bateman , Jeff Brown , Martin Green
发明人： Robert Harold Bateman , Jeff Brown , Martin Green
IPC分类号： H01J49/00
CPC分类号： H01J49/025 , H01J43/246
摘要： An ion detector for a mass spectrometer is disclosed comprising a microchannel plate 8 which receives ions 12 at an input surface and releases electrons 16 from an output surface. A detecting device is arranged to receive at least some of the electrons 16 emitted from the microchannel plate 8. The detecting device receives electrons 16 on a first portion of the detecting device at a first time t1 and receives electrons 16 on a second different portion of the detector at a second later time t2. Time-varying electric and/or magnetic fields are applied between the microchannel plate 8 and the detecting device to guide electrons 16 emitted from the microchannel plate onto different regions of the detecting device in a time varying manner.
摘要翻译： 公开了一种用于质谱仪的离子检测器，其包括微通道板8，微通道板8在输入表面处接收离子12并从输出表面释放电子16。 检测装置被布置成接收从微通道板8发射的至少一些电子16。 检测装置在第一时刻t 1在检测装置的第一部分上接收电子16，并在第二时间t 2接收检测器的第二不同部分上的电子16， / SUB>。 在微通道板8和检测装置之间施加时变电场和/或磁场，以便以时变方式将从微通道板发射的电子16引导到检测装置的不同区域上。
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公开(公告)号：US07102126B2
公开(公告)日：2006-09-05
申请号：US10636774
申请日：2003-08-08
申请人： Robert Harold Bateman , Jeff Brown
发明人： Robert Harold Bateman , Jeff Brown
IPC分类号： H01J49/26
CPC分类号： H01J49/004 , H01J49/0481 , H01J49/40 , H01J49/424
摘要： A mass spectrometer is disclosed wherein a relatively energetic pulse of ions having a relatively narrow spread of mass to charge ratios are ejected from a quadrupole ion trap and received in an ion trap upstream of a Time of Flight mass analyser. The ions are collisionally cooled within the ion trap and are pulsed out of the ion trap and into an extraction region of the Time of Flight mass analyser without substantially exciting the ions. This enables improved operation with the Time of Flight mass analyser. According to another embodiment, parent ions are fragmented and the resulting fragment ions are stored in two ion traps having different low mass cut-offs. The trapping system enables MS/MS experiments to be performed with a very high duty cycle.
摘要翻译： 公开了一种质谱仪，其中具有相对较窄的质荷比扩散的相对高能的离子脉冲从四极离子阱排出并被接收在飞行时间质量分析器上游的离子阱中。 离子在离子阱内被碰撞冷却，并从离子阱中脉冲出并进入飞行时间质量分析仪的提取区域，而基本上不激励离子。 这可以通过“飞行时间”质量分析仪进行改进的操作。 根据另一个实施方案，母体离子是碎片化的，所得到的碎片离子存储在具有不同低质量截止值的两个离子阱中。 捕获系统能够以非常高的占空比执行MS / MS实验。
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