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公开(公告)号：US07081482B2
公开(公告)日：2006-07-25
申请号：US10130408
申请日：2000-11-29
IPC分类号： A61K31/135
CPC分类号： A61K31/165 , A61K31/138 , A61K31/222 , A61K31/34 , A61K31/343 , A61K31/404 , A61K31/4704 , A61K31/5377 , Y10S514/912
摘要： The invention is directed to the use of β-adrenoceptor antagonists for the manufacture of a medicament for the treatment of disorders of the outer retina.
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公开(公告)号：US5710165A
公开(公告)日：1998-01-20
申请号：US271290
申请日：1994-07-06
IPC分类号： A61K31/00 , A61K31/445 , A01N43/40
CPC分类号： A61K31/445 , A61K31/00 , Y10S514/913
摘要： Polyamine antagonists are found to be effective in preventing or reducing visual field loss associated with glaucoma. Especially preferred are certain 1-phenyl-2-piperidinoalkanol derivatives, such as eliprodil and ifenprodil.
摘要翻译： 发现多胺拮抗剂有效预防或减少与青光眼有关的视野丧失。 特别优选的是1-苯基-2-哌啶子基链烷醇衍生物，例如厄洛替丁和伊芬醌。
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公开(公告)号：US6020352A
公开(公告)日：2000-02-01
申请号：US972833
申请日：1997-11-18
IPC分类号： C07D211/18 , A61K31/00 , A61K31/445 , A61K45/00 , A61P27/00 , A61P27/02 , A61P43/00
CPC分类号： A61K31/445 , Y10S514/912
摘要： The use of polyamine site antagonists in treating ischemic disorders of the retina and optic nerve head are disclosed. Especially preferred are certain 1-phenyl-2-piperidinoalkanol derivatives, such as eliprodil and ifenprodil.
摘要翻译： 公开了使用多胺位点拮抗剂治疗视网膜和视神经头的缺血性疾病。 特别优选的是1-苯基-2-哌啶子基链烷醇衍生物，例如厄洛替丁和伊芬醌。
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公开(公告)号：US06344478B2
公开(公告)日：2002-02-05
申请号：US09777409
申请日：2001-02-06
IPC分类号： A61K31557
CPC分类号： C07C405/00 , A61K9/0048 , A61K31/557 , A61K31/5575 , A61K31/558 , A61K45/06 , C07C405/0025 , Y10S514/912 , Y10S514/913 , A61K2300/00
摘要： Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
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公开(公告)号：US5932572A
公开(公告)日：1999-08-03
申请号：US920314
申请日：1997-08-27
IPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , A61K31/535
CPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , Y10S514/913
摘要： Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor to reduce the production of aqueous humor, preferably formulated as a suspension having a pH between about 6.8 and about 7.8. These compositions may additionally contain a mucomimetic anionic polymer and/or a finely-divided drug carrier substrate to provide sustained release. A method of controlling elevated intraocular pressure with these compositions is also described.
摘要翻译： 描述了可用于控制与青光眼和高眼压症相关的升高的眼内压的眼用药物组合物。 组合物包含β-阻断剂和碳酸酐酶抑制剂的组合以减少房水的产生，优选配制为pH在约6.8至约7.8之间的悬浮液。 这些组合物可另外含有模拟阴离子聚合物和/或细碎药物载体底物以提供持续释放。 还描述了使用这些组合物来控制眼内压升高的方法。
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公开(公告)号：US06316441B1
公开(公告)日：2001-11-13
申请号：US09832998
申请日：2001-04-11
IPC分类号： A61K31535
CPC分类号： A61K31/542 , A61K31/498 , A61K31/54 , Y10S514/912 , Y10S514/913 , A61K2300/00 , A61K31/495
摘要： Methods and compositions for treating ocular conditions which find their etiology in compromised ocular blood flow with brinzolamide and brimonidine are disclosed.
摘要翻译： 公开了用于治疗眼睛病症的方法和组合物，其用于使用布林唑胺和溴莫尼定在眼损伤的血流中发现其病因。
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公开(公告)号：US06242442B1
公开(公告)日：2001-06-05
申请号：US09601634
申请日：2000-08-04
IPC分类号： A67K31535
CPC分类号： A61K31/542 , A61K31/498 , A61K31/54 , Y10S514/912 , Y10S514/913 , A61K2300/00 , A61K31/495
摘要： Methods and compositions for treating ocular conditions which find their etiology in compromised ocular blood flow with brinzolamide and brimonidine are disclosed.
摘要翻译： 公开了用于治疗眼睛病症的方法和组合物，其用于使用布林唑胺和溴莫尼定在眼损伤的血流中发现其病因。
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