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公开(公告)号：US08180454B2
公开(公告)日：2012-05-15
申请号：US11607201
申请日：2006-12-01
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译： 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。
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公开(公告)号：US20080294223A1
公开(公告)日：2008-11-27
申请号：US11925285
申请日：2007-10-26
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译： 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。
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公开(公告)号：US08190267B2
公开(公告)日：2012-05-29
申请号：US11925285
申请日：2007-10-26
申请人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Ione Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Weiland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
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公开(公告)号：US09597495B2
公开(公告)日：2017-03-21
申请号：US13452300
申请日：2012-04-20
申请人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of identifying a preferred location for an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject and array location to array location. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the preferred location. Alternatively, electrode height may be measured directly to predict the preferred location.
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公开(公告)号：US20120203293A1
公开(公告)日：2012-08-09
申请号：US13452300
申请日：2012-04-20
申请人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert J. Greenberg , Jone Fine , Arup Roy , Matthew J. McMahon , Mark S. Humayun , James David Welland , Alan M. Horsager , Dao Min Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/372
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of identifying a preferred location for an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject and array location to array location. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the preferred location. Alternatively, electrode height may be measured directly to predict the preferred location.
摘要翻译： 本发明是一种将电极阵列的优选位置识别为个体对象的神经特征的方法。 对电神经刺激的反应从主体到主体和阵列位置到阵列位置不同。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测优选的位置。 或者，可以直接测量电极高度以预测优选位置。
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公开(公告)号：US20070191911A1
公开(公告)日：2007-08-16
申请号：US11607201
申请日：2006-12-01
申请人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon , Mark Humayun , James Weiland , Alan Horsager , Dao Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
发明人： Robert Greenberg , Ione Fine , Arup Roy , Matthew McMahon , Mark Humayun , James Weiland , Alan Horsager , Dao Zhou , Amy Hines , Sumit Yadav , Rongqing Dai
IPC分类号： A61N1/18
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译： 本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。 对电神经刺激的反应因受试者而异。 可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。 或者，可以直接测量电极高度以预测感知阈值。 此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。
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公开(公告)号：US08423151B2
公开(公告)日：2013-04-16
申请号：US11926057
申请日：2007-10-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. Systems and stimulator control mechanisms to prevent damage to neural tissue.
摘要翻译： 在电刺激神经组织中，重要的是防止过度刺激和不平衡刺激，这将导致对神经组织，电极或两者的损伤。 至关重要的是神经组织不会受到高于安全阈值的任何直流或交流电流的影响。 此外，重要的是识别有缺陷的电极，因为继续使用可能导致神经和电极损坏。 系统和刺激物控制机制，以防止损伤神经组织。
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公开(公告)号：US08170682B2
公开(公告)日：2012-05-01
申请号：US11927391
申请日：2007-10-29
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译： 本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。 本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。 本公开中提出的装置包括能够执行所公开的方法的电路和系统。
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公开(公告)号：US09974953B2
公开(公告)日：2018-05-22
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： An apparatus for controlling the stimulation of neural tissue which includes a neural stimulator, an input device for providing input to the neural stimulator for neural stimulation, at least one electrode electrically connected to and driven by the neural stimulator and suitable to stimulate neural tissue, a device capable of determining a charge per phase by calculating a discrete integral of the wave form of the input for the at least one electrode, a calculating device for comparing the charge per phase to a predetermined maximum and determining a reduced stimulation for the at least one electrode by the amount necessary not to exceed the predetermined maximum for the at least one electrode, and a current pulse generator for stimulating the neural tissue according to the reduced stimulation level.
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公开(公告)号：US09913985B2
公开(公告)日：2018-03-13
申请号：US11413771
申请日：2006-04-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.
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