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公开(公告)号：US5362855A
公开(公告)日：1994-11-08
申请号：US65170
申请日：1993-05-20
IPC分类号： A61K38/16 , A61K38/00 , C07K1/107 , C07K1/14 , C07K14/00 , C07K14/805 , C07C103/52 , A61K37/00
CPC分类号： C07K14/805 , A61K38/00
摘要： An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mm Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.
摘要翻译： 用于将氧气输送到活细胞中并且基本上不含任何杂质的亚胺酯交联血红蛋白组合物，P50至少为13mm Hg，主要是四聚体形式。 优选地，交联血红蛋白组合物具有至少64,000的主要分子量。 纯化和交联的血红蛋白具有改善的自身氧化的交联稳定性，并且可以用作哺乳动物或氧输送液的血液替代物。
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公开(公告)号：US5521154A
公开(公告)日：1996-05-28
申请号：US260173
申请日：1994-06-15
CPC分类号： C07K14/805 , A61K38/00
摘要： An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13mm Hg and predominantly in tetraruer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.
摘要翻译： 用于将氧气输送到活细胞并且基本上不含任何杂质的亚胺酯交联血红蛋白组合物，P50至少为13mm Hg，主要是四种形式。 优选地，交联血红蛋白组合物具有至少64,000的主要分子量。 纯化和交联的血红蛋白具有改善的自身氧化的交联稳定性，并且可以用作哺乳动物或氧输送液的血液替代物。
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公开(公告)号：US5631227A
公开(公告)日：1997-05-20
申请号：US462255
申请日：1995-06-05
CPC分类号： C07K14/61
摘要： The present invention provides analogs of somatotropins wherein the asparagine residue corresponding to position 99 of a bovine somatotropin is replaced with a compound selected from the group consisting of proline, aspartic acid, glutamic acid, serine, glycine, serine-serine or serine-aspartic acid. Particularly preferred analogs are bovine somatotropin and their use to increase milk production.
摘要翻译： 本发明提供生长激素类似物，其中相应于牛生长激素的第99位的天冬酰胺残基被选自脯氨酸，天冬氨酸，谷氨酸，丝氨酸，甘氨酸，丝氨酸丝氨酸或丝氨酸 - 天冬氨酸的化合物所取代 。 特别优选的类似物是牛生长激素及其用于增加产奶量的用途。
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4.发明授权
公开(公告)号：US5698418A
公开(公告)日：1997-12-16
申请号：US470296
申请日：1995-06-06
申请人： David P. Brunner , Gary C. Harbour , Richard J. Kirschner , James F. Pinner , Robert L. Garlick
发明人： David P. Brunner , Gary C. Harbour , Richard J. Kirschner , James F. Pinner , Robert L. Garlick
CPC分类号： C07K14/61 , C12N1/20 , C12P1/00 , C12P13/04 , Y10S435/849
摘要： The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
摘要翻译： 本发明提供了用于生长微生物的廉价的发酵培养基。 还提供了发酵培养基和通过在其上生长大肠杆菌来生产正亮氨酸的方法，发酵培养基和将正亮氨酸掺入由其上生长的微生物表达的多肽的方法，以及发酵培养基和用于防止将正亮氨酸掺入由其上生长的微生物表达的多肽的方法 。 还提供了牛生长激素类似物。
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公开(公告)号：US5622845A
公开(公告)日：1997-04-22
申请号：US470683
申请日：1995-06-06
申请人： David P. Brunner , Gary C. Harbour , Richard J. Kirschner , James F. Pinner , Robert L. Garlick
发明人： David P. Brunner , Gary C. Harbour , Richard J. Kirschner , James F. Pinner , Robert L. Garlick
CPC分类号： C07K14/61 , C12N1/20 , C12P1/00 , C12P13/04 , Y10S435/849
摘要： The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
摘要翻译： 本发明提供了用于生长微生物的廉价的发酵培养基。 还提供了发酵培养基和通过在其上生长大肠杆菌来生产正亮氨酸的方法，发酵培养基和将正亮氨酸掺入由其上生长的微生物表达的多肽的方法，以及发酵培养基和用于防止将正亮氨酸掺入由其上生长的微生物表达的多肽的方法 。 还提供了牛生长激素类似物。
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