-
公开(公告)号：US20090131411A1
公开(公告)日：2009-05-21
申请号：US11924480
申请日：2007-10-25
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： A61K31/4439 , A61P7/00 , C07D409/14 , C07D409/12 , C07D413/14 , C07D417/14 , A61K31/541 , A61K31/5377 , A61K31/55 , A61K31/506 , A61K31/4545
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号：US06720317B1
公开(公告)日：2004-04-13
申请号：US09662807
申请日：2000-09-15
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D23114
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号：US06686368B1
公开(公告)日：2004-02-03
申请号：US10387927
申请日：2003-03-12
申请人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
发明人： Bing-Yan Zhu , Zhaozhong Jon Jia , Wenrong Huang , Yonghong Song , James Kanter , Robert M. Scarborough
IPC分类号： C07D40112
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
-
公开(公告)号：US06638980B1
公开(公告)日：2003-10-28
申请号：US09576633
申请日：2000-05-24
IPC分类号： A61K31165
CPC分类号： C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
-
公开(公告)号：US06545054B1
公开(公告)日：2003-04-08
申请号：US09501370
申请日：2000-02-11
IPC分类号： A61K3118
CPC分类号： C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
摘要： Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show selectivity for factor Xa over other proteases of the coagulation (e.g., thrombin, fvIIa, flXa) or the fibrinolytic cascades (e.g., plasminogen activators, plasmin). Methods for using such alkenyl and alkynyl compounds as diagnostic or therapeutic agents for prevention or treatment of a condition in a mammal characterized by undesired coagulation disorders, such as thrombosis, are also described.
摘要翻译： 描述了作为在凝血酶原酶复合物中分离或组装的因子Xa的有效和高选择性抑制剂的烯基和炔基化合物以及含有这种烯基和炔基化合物的组合物。 这些化合物显示对凝血因子Xa（例如凝血酶，fvIIa，flXa）或纤维蛋白溶解级联（例如纤溶酶原激活剂，纤溶酶）的其它蛋白酶的选择性。 还描述了使用这种烯基和炔基化合物作为诊断或治疗剂来预防或治疗特征在于不期望的凝血障碍如血栓形成的哺乳动物状况的方法。
-
公开(公告)号：US06245743B1
公开(公告)日：2001-06-12
申请号：US09077001
申请日：1998-05-15
IPC分类号： A61K3800
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/06086 , C07K5/06095 , C07K5/0817
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号：US06211183B1
公开(公告)日：2001-04-03
申请号：US09058564
申请日：1998-04-13
IPC分类号： A61K3169
CPC分类号： C07D295/205 , C07D211/26 , C07D241/08 , C07D243/08 , C07D295/15 , C07D401/06 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
-
公开(公告)号：US6046169A
公开(公告)日：2000-04-04
申请号：US486386
申请日：1995-06-07
CPC分类号： C07K5/06191 , A61K38/00
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号：US08518977B2
公开(公告)日：2013-08-27
申请号：US13247937
申请日：2011-09-28
申请人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
发明人： Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick A. Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert M. Scarborough
IPC分类号： C07D213/75 , A61K31/44
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译： 描述了具有抗哺乳动物因子Xa活性的新型苯甲酰胺化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物。 还描述了含有这些化合物的组合物。 化合物和组合物在体外或体内可用于预防或治疗凝血障碍。
-
公开(公告)号：US08153670B2
公开(公告)日：2012-04-10
申请号：US12348879
申请日：2009-01-05
申请人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人： Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号： C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
-
-
-
-
-
-
-
-
-
搜索结果
101 条记录 (耗时 0.052 秒)
