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    Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
    4.
    发明申请
    Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases 有权
    磷酸二酯酶抑制剂和一氧化氮，活性氧和金属蛋白酶调节剂在治疗白血病，动脉硬化等纤维化疾病中的应用

    公开(公告)号：US20050085486A1

    公开(公告)日：2005-04-21

    申请号：US10779069

    申请日：2004-02-13

    Applicant: Nestor Gonzalez-Cadavid ,  Jacob Rajfer

    Inventor： Nestor Gonzalez-Cadavid ,  Jacob Rajfer

    IPC: A61K31/00 ,  A61K31/519 ,  A61K48/00 ,  C12N15/861

    CPC classification number: A61K31/53 ,  A61K9/0053 ,  A61K31/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K48/00 ,  A61K48/005 ,  A61K2201/094 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    Abstract: The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and/or PKG, a stimulator of guanylyl cyclase and/or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

    Abstract translation: 本发明的方法和组合物可用于治疗涉及纤维化的病症，例如佩罗尼氏病斑块，阴茎肉纤维化，阴茎静脉闭塞功能障碍，杜鹃花结节，阴道纤维化，阴蒂纤维化，女性性唤起障碍，异常伤口愈合， 瘢痕疙瘩形成，肾，膀胱，前列腺，皮肤，肝，肺，心脏，肠或其他局部或全身性纤维化病症的一般纤维化，血管纤维化，动脉内膜增生，动脉粥样硬化，动脉硬化，再狭窄，心脏肥大，高血压或任何 其特征在于过度的成纤维细胞或平滑肌细胞增殖或血管和/或心脏中胶原和细胞外基质的沉积。 在某些实施方案中，组合物可以包含PDE-4抑制剂，PDE-5抑制剂，升高cGMP和/或PKG的化合物，鸟苷酸环化酶和/或PKG的刺激剂，提高cGMP的化合物的组合，PKG 或NO与降低ROS的抗氧化剂，或增加MMP活性的化合物。

    Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie's Disease, Arteriosclerosis and Other Fibrotic Diseases
    7.
    发明申请
    Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie's Disease, Arteriosclerosis and Other Fibrotic Diseases 审中-公开
    使用磷酸二酯酶抑制剂和一氧化氮，活性氧物质和金属蛋白酶调节剂治疗佩罗尼氏病，动脉硬化和其他纤维化疾病的方法

    公开(公告)号：US20120141454A1

    公开(公告)日：2012-06-07

    申请号：US13372094

    申请日：2012-02-13

    Applicant: Nestor F. Gonzalez-Cadavid ,  Jacob Rajfer

    Inventor： Nestor F. Gonzalez-Cadavid ,  Jacob Rajfer

    IPC: A61K31/4985 ,  A61P15/00 ,  A61K38/48 ,  A61K31/519 ,  A61K31/53

    CPC classification number: A61K31/53 ,  A61K9/0053 ,  A61K31/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K48/00 ,  A61K48/005 ,  A61K2201/094 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    Abstract: The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and/or PKG, a stimulator of guanylyl cyclase and/or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

    Abstract translation: 本发明的方法和组合物可用于治疗涉及纤维化的病症，例如佩罗尼氏病斑块，阴茎肉纤维化，阴茎静脉闭塞功能障碍，杜鹃花结节，阴道纤维化，阴蒂纤维化，女性性唤起障碍，异常伤口愈合， 瘢痕疙瘩形成，肾，膀胱，前列腺，皮肤，肝，肺，心脏，肠或其他局部或全身性纤维化病症的一般纤维化，血管纤维化，动脉内膜增生，动脉粥样硬化，动脉硬化，再狭窄，心脏肥大，高血压或任何 其特征在于过度的成纤维细胞或平滑肌细胞增殖或血管和/或心脏中胶原和细胞外基质的沉积。 在某些实施方案中，组合物可以包含PDE-4抑制剂，PDE-5抑制剂，升高cGMP和/或PKG的化合物，鸟苷酸环化酶和/或PKG的刺激剂，提高cGMP的化合物的组合，PKG 或NO与降低ROS的抗氧化剂，或增加MMP活性的化合物。

    Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
    8.
    发明授权
    Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases 有权
    磷酸二酯酶抑制剂和一氧化氮，活性氧和金属蛋白酶调节剂在治疗白血病，动脉硬化等纤维化疾病中的应用

    公开(公告)号：US08133903B2

    公开(公告)日：2012-03-13

    申请号：US10779069

    申请日：2004-02-13

    Applicant: Nestor F. Gonzalez-Cadavid ,  Jacob Rajfer

    Inventor： Nestor F. Gonzalez-Cadavid ,  Jacob Rajfer

    IPC: A01N43/42

    CPC classification number: A61K31/53 ,  A61K9/0053 ,  A61K31/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K48/00 ,  A61K48/005 ,  A61K2201/094 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    Abstract: The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and/or PKG, a stimulator of guanylyl cyclase and/or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

    Abstract translation: 本发明的方法和组合物可用于治疗涉及纤维化的病症，例如佩罗尼氏病斑块，阴茎肉纤维化，阴茎静脉闭塞功能障碍，杜鹃花结节，阴道纤维化，阴蒂纤维化，女性性唤起障碍，异常伤口愈合， 瘢痕疙瘩形成，肾，膀胱，前列腺，皮肤，肝，肺，心脏，肠或其他局部或全身性纤维化病症的一般纤维化，血管纤维化，动脉内膜增生，动脉粥样硬化，动脉硬化，再狭窄，心脏肥大，高血压或任何 其特征在于过度的成纤维细胞或平滑肌细胞增殖或血管和/或心脏中胶原和细胞外基质的沉积。 在某些实施方案中，组合物可以包含PDE-4抑制剂，PDE-5抑制剂，升高cGMP和/或PKG的化合物，鸟苷酸环化酶和/或PKG的刺激剂，提高cGMP的化合物的组合，PKG 或NO与降低ROS的抗氧化剂，或增加MMP活性的化合物。

    Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie's Disease, Arteriosclerosis and Other Fibrotic Diseases
    10.
    发明申请
    Methods of Use of Inhibitors of Phosphodiesterases and Modulators of Nitric Oxide, Reactive Oxygen Species, and Metalloproteinases in the Treatment of Peyronie's Disease, Arteriosclerosis and Other Fibrotic Diseases 审中-公开
    使用磷酸二酯酶抑制剂和一氧化氮，活性氧物质和金属蛋白酶调节剂治疗佩罗尼氏病，动脉硬化和其他纤维化疾病的方法

    公开(公告)号：US20140350021A1

    公开(公告)日：2014-11-27

    申请号：US14453543

    申请日：2014-08-06

    Applicant: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

    Inventor： Nestor F. Gonzalez-Cadavid ,  Jacob Rajfer

    IPC: A61K31/4985 ,  A61K31/53 ,  A61K31/519

    CPC classification number: A61K31/53 ,  A61K9/0053 ,  A61K31/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K48/00 ,  A61K48/005 ,  A61K2201/094 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/85

    Abstract: The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and/or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and/or PKG, a stimulator of guanylyl cyclase and/or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

    Abstract translation: 本发明的方法和组合物可用于治疗涉及纤维化的病症，例如佩罗尼氏病斑块，阴茎肉纤维化，阴茎静脉闭塞功能障碍，杜鹃花结节，阴道纤维化，阴蒂纤维化，女性性唤起障碍，异常伤口愈合， 瘢痕疙瘩形成，肾，膀胱，前列腺，皮肤，肝，肺，心脏，肠或其他局部或全身性纤维化病症的一般纤维化，血管纤维化，动脉内膜增生，动脉粥样硬化，动脉硬化，再狭窄，心脏肥大，高血压或任何 其特征在于过度的成纤维细胞或平滑肌细胞增殖或血管和/或心脏中胶原和细胞外基质的沉积。 在某些实施方案中，组合物可以包含PDE-4抑制剂，PDE-5抑制剂，升高cGMP和/或PKG的化合物，鸟苷酸环化酶和/或PKG的刺激剂，提高cGMP的化合物的组合，PKG 或NO与降低ROS的抗氧化剂，或增加MMP活性的化合物。

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