公开(公告)号：US20120053574A1

公开(公告)日：2012-03-01

申请号：US13219895

申请日：2011-08-29

申请人： Robert Murray, III ,  Paul Cassidy

发明人： Robert Murray, III ,  Paul Cassidy

IPC分类号： A61B17/00

CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9517

摘要： The present invention is directed to an improved delivery system to deliver and deploy a prosthesis in a body lumen, and methods of use thereof. The improved delivery system allows for operation of the delivery system with one hand while maintaining accuracy in delivery and deployment of the prosthesis. An exemplary embodiment of the delivery system includes a first sheath control on a housing so as to be accessible from the exterior of the housing, wherein the first sheath control is operatively engaged with the sheath and controls movement of the sheath axially proximally with respect to the housing, thereby releasing at least a portion of the prosthesis.

摘要翻译： 本发明涉及一种用于在体腔内递送和展开假体的改进的递送系统及其使用方法。 改进的输送系统允许一只手的输送系统的操作，同时保持假体的输送和部署的准确性。 递送系统的示例性实施例包括在壳体上的第一护套控制，以便可从壳体的外部接近，其中第一护套控制器与护套可操作地接合并且控制护套相对于外壳的轴向向近侧的运动 壳体，从而释放假体的至少一部分。

公开(公告)号：US09198788B2

公开(公告)日：2015-12-01

申请号：US13219895

申请日：2011-08-29

申请人： Robert Murray, III ,  Paul Cassidy

发明人： Robert Murray, III ,  Paul Cassidy

IPC分类号： A61F2/06 ,  A61F2/966 ,  A61F2/95

CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2002/9517

摘要： The present invention is directed to an improved delivery system to deliver and deploy a prosthesis in a body lumen, and methods of use thereof. The improved delivery system allows for operation of the delivery system with one hand while maintaining accuracy in delivery and deployment of the prosthesis. An exemplary embodiment of the delivery system includes a first sheath control on a housing so as to be accessible from the exterior of the housing, wherein the first sheath control is operatively engaged with the sheath and controls movement of the sheath axially proximally with respect to the housing, thereby releasing at least a portion of the prosthesis.

摘要翻译： 本发明涉及一种用于在体腔内递送和展开假体的改进的递送系统及其使用方法。 改进的输送系统允许一只手的输送系统的操作，同时保持假体的输送和部署的准确性。 递送系统的示例性实施例包括在壳体上的第一护套控制，以便可从壳体的外部接近，其中第一护套控制器与护套可操作地接合并且控制护套相对于外壳的轴向向近侧的运动 壳体，从而释放假体的至少一部分。

公开(公告)号：US06964681B2

公开(公告)日：2005-11-15

申请号：US10060206

申请日：2002-01-29

申请人： Robert Murray, III

发明人： Robert Murray, III

IPC分类号： A61F2/00 ,  A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/067 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0013 ,  A61F2250/0037 ,  A61F2250/0039

摘要： A tubular stent that uniformly scaffolds vessel tissue within a region that significantly changes diameter or transverse dimension. The invention may be practiced in lumens that taper in either retrograde or antegrade directions, and the transverse dimensional change may be relatively linear or flared. A catheter for delivering the stent of the invention may include a balloon having a comparably flared shape and an inverse conical distal end. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

摘要翻译： 一种管状支架，其能够在显着改变直径或横向尺寸的区域内均匀地支架血管组织。 本发明可以在逆行或顺行方向上逐渐变细的腔内实施，并且横向尺寸变化可以是相对线性的或扩张的。 用于输送本发明的支架的导管可以包括具有相对扩张形状和倒锥形远端的球囊。 提供本摘要以符合要求抽象的规则，这将允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。

公开(公告)号：US20110270339A1

公开(公告)日：2011-11-03

申请号：US12771029

申请日：2010-04-30

申请人： Robert Murray, III ,  Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Erik Griswold ,  Scott Doig ,  John Kantor

发明人： Robert Murray, III ,  Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Erik Griswold ,  Scott Doig ,  John Kantor

IPC分类号： A61N1/05

CPC分类号： A61N1/375 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756 ,  A61N2001/058

摘要： Systems and methods of delivering and retaining a leadless medical implant to tissue, wherein a docking base and the implant are sequentially delivered to an implantation site. In a first stage, the docking base is delivered and deployed into tissue at an implantation site. In a second stage, the implant is navigated through the vasculature and coupled to the docking base. Various mechanisms for navigating the implant to the previously implanted docking base and coupling the implant thereto are described. Navigational mechanisms include advancing the implant over a proximally extending wire portion that is releasably attached to the previously implanted docking base, utilizing fluoroscopic visualization to guide the implant to a previously implanted docking base that is at least partially radiopaque and utilizing electromagnetism to guide the implant to a previously implanted docking base that is electro-magnetizable.

公开(公告)号：US08512401B2

公开(公告)日：2013-08-20

申请号：US12758443

申请日：2010-04-12

申请人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

发明人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2002/9517 ,  A61F2002/9534

摘要： A delivery device for percutaneously deploying a stented prosthetic heart valve. The device includes a delivery capsule and a recapture sheath. The capsule is configured to compressively retain the prosthesis. The recapture sheath includes a funnel segment having a plurality of circumferentially spaced runners and a polymer overlay. The runners are attached to a shaft and terminate at a distal tip. The overlay surrounds the runners, and is bonded to the shaft but not to at least the tips. The funnel segment is transitionable from a normal condition to an expanded condition forming a funnel shape with a distally increasing diameter, and self-transitionable back toward the normal condition. The funnel segment facilitates sliding of the capsule over a partially deployed region of the prosthesis as part of a recapturing operation. The runners provide columnar strength, with the overlay controlling a shape of the funnel segment.

公开(公告)号：US20110251682A1

公开(公告)日：2011-10-13

申请号：US12758443

申请日：2010-04-12

申请人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

发明人： Robert Murray, III ,  Susheel Deshmukh ,  Padraig Savage ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2002/9517 ,  A61F2002/9534

摘要： A delivery device for percutaneously deploying a stented prosthetic heart valve. The device includes a delivery capsule and a recapture sheath. The capsule is configured to compressively retain the prosthesis. The recapture sheath includes a funnel segment having a plurality of circumferentially spaced runners and a polymer overlay. The runners are attached to a shaft and terminate at a distal tip. The overlay surrounds the runners, and is bonded to the shaft but not to at least the tips. The funnel segment is transitionable from a normal condition to an expanded condition forming a funnel shape with a distally increasing diameter, and self-transitionable back toward the normal condition. The funnel segment facilitates sliding of the capsule over a partially deployed region of the prosthesis as part of a recapturing operation. The runners provide columnar strength, with the overlay controlling a shape of the funnel segment.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的输送装置。 该装置包括递送胶囊和再捕获护套。 胶囊被构造成压缩地保持假体。 重新捕获鞘包括具有多个周向间隔的流道和聚合物覆盖层的漏斗段。 流道附着在轴上，并终止于远端。 覆盖物围绕流道，并且结合到轴，但至少不是尖端。 漏斗段可以从正常状态转变成扩展状态，形成具有向远端增加的直径的漏斗形状，并且可自由转变回正常状态。 漏斗段有助于将胶囊滑动在假体的部分展开的区域上，作为重新捕获操作的一部分。 跑步者提供柱状强度，覆盖层控制漏斗段的形状。

公开(公告)号：US20110251679A1

公开(公告)日：2011-10-13

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US08491650B2

公开(公告)日：2013-07-23

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US07867269B2

公开(公告)日：2011-01-11

申请号：US11268389

申请日：2005-11-07

申请人： Robert Murray, III

发明人： Robert Murray, III

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/067 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2230/0013 ,  A61F2250/0037 ,  A61F2250/0039

摘要： A tubular stent that uniformly scaffolds vessel tissue within a region that significantly changes diameter or transverse dimension. The invention may be practiced in lumens that taper in either retrograde or antegrade directions, and the transverse dimensional change may be relatively linear or flared. A catheter for delivering the stent of the invention may include a balloon having a comparably flared shape and an inverse conical distal end. This abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).

摘要翻译： 一种管状支架，其能够在显着改变直径或横向尺寸的区域内均匀地支架血管组织。 本发明可以在逆行或顺行方向上逐渐变细的腔内实施，并且横向尺寸变化可以是相对线性的或扩张的。 用于输送本发明的支架的导管可以包括具有相对扩张形状和倒锥形远端的球囊。 提供本摘要以符合要求抽象的规则，这将允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR 1.72（b）。